... Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process Orane Visvikis1,2, Patrick Lore`s1,2, Laurent Boyer3, Pierre Chardin4, ... polyubiquitination and subsequent proteasomal degradation inHEK293 cells, Rac1b is poorly ubiquitinated and appears to be much moreresistant to proteasomal degradation than Rac1L61. Mutational analysis ... Indeed, in Rac2 and Rac3, whichare resistant to proteasomal degradation, Lys1 47 is either absent (Rac3), or is in a different environment ascompared to Rac1 (Rac2). Lys1 47 is not conservedamong Rho...