Báo cáo y học: "Choosing the right path: enhancement of biologically relevant sets of genes or proteins using pathway structure" ppt
Báo cáo y học: "Choosing the right path: enhancement of biologically relevant sets of genes or proteins using pathway structure" ppt
... changes in expression of the genes in the pathway are higher than that of the rest of the genes in the system). In the situation of low values of the CF factor, the Schematic of networks used to generate ... the goal is to compare the genes in the pathway of interest to the other genes in the system in terms of their associations with the treatment. SEPEA_NT2 is used for analyses involvingonly the ... the genes in the pathway in relation to the treatment. The main objective of this paper is to demonstrate the utility of incorporating pathway network information in a pathway enrichment analysis....
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Báo cáo khoa học: "Choosing the right combination therapy in severe community-acquired pneumonia" pdf
... level of uncertainty aboutoptimal therapy exists. The large number of differentcombinations chosen by physicians in the study byMortensen et al. [10] is a clear indication that the therapeuticuncertainty ... second possibility, put forward by Mortensen et al. [10], isthat their findings favouring macrolides are due to the immunomodulatory properties of this class of antibiotics. Inhealthy subjects macrolides ... interferon-γ [14], a keycytokine in the restoration of immune function after sepsis-induced immunoparalysis. Macrolides have also been reportedto downregulate the production of reactive oxygen species,blocking...
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Báo cáo y học: "’Choosing shoes’: a preliminary study into the challenges facing clinicians in assessing footwear for rheumatoid patients" pot
... havebeen previously reported [9,28-31], this type of footwearwas not widely worn by patients in the current study.Additionally there are known factors relating to pooruse of therapeutic footwear ... mobility [1]. The foot is often the first area of the body to be sys-tematically afflicted by RA [2-4]. Seventy-five percent(75%) of patients with RA report foot pain within fouryears of diagnosis, ... footwear either becausetheir foot symptoms had resolved or because they hadfoot surgery [32].In the c urrent study the participants reported that fitand comfort were important factors in choosing...
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Báo cáo y học: "Double chambered right ventricle with severe calcification of the tricuspid valve in an elderly woman: a case report" ppsx
... obtained from the patientfor publicatio n of this case report and any accompany-ing images. A copy of the written consent is availablefor review by the Editor-in-Chief of this journal.AbbreviationsCT: ... ventricle. To the best of our knowledge, there is no other case report of this combination of DCRV and calcification of the tri-cuspid valve.ConsentWritten informed consent was obtained from the patientfor ... in the RVOT stenosis. Reports of calcifica-tion in the tricuspid valve are very rare [4-7]. The mechanism of calcificatio n of the tricuspid valve is con-sideredtobeduetothehighpressureorvolumeover-load...
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Báo cáo y học: " Recruit the lung before titrating the right positive end-expiratory pressure to protect it" ppsx
... volumes for acute lung injury and the acute respi-ratory distress syndrome. The Acute Respiratory DistressSyndrome Network. N Engl J Med 2000, 342:1301-1308.11. Lim CM, Koh Y, Park W, Chin JY, Shim ... PaO2determined the closing pressure yielded open-lung PEEPvalues of the order of 18 to 20 cm H2O [4,8]. These valuesare similar to the ones reported by Gattinoni and colleagues[13] in the mid-1990s using ... seriously limit the ability of a decremental PEEPtrial to find open-lung PEEP. Furthermore, the investigatorsused falling oxygen saturation and decaying staticcompliances to select their PEEP, thereby...
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Báo cáo y học: "Demonstrating the benefit of medical emergency teams (MET) proves more difficult than anticipated"
... anticipated. These factors significantly reduced the power of the study. Based on their findings, the authors estimate that more than 100 hospitals would be needed to show the 30% difference they sought. ... the MET system was left to the local hospital. No efforts were made by the investigators to reinforce MET concepts or to assess how well the MET concept was implemented. Furthermore, the MET ... goal of identifying and treating patients early in the course of their illness is preferable to waiting until more serious signs and symptoms have developed. Certainly, at the University of...
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Báo cáo y học: " Introducing the Critical Care Forum’s ongoing review of medical statistics"
... or the management of patients have a sound grasp of at least the basics of statistical methods. Unfortunately, in practice this isoften not true, with many relying on distant memories of poorly ... increasingly used in all fields of medicine but is often poorly understood and incorrectlyapplied. Critical Care is therefore launching a series of articles aimed at providing a simple introduction or ... theory andassumptions behind them.This series does not claim to be a complete course inmedical statistics. There are many useful introductory textsEditorialIntroducing the Critical Care Forum’s...
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Báo cáo y học: "Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects"
... for the thermolability of MTHFR. Actually, the frequency of the mutated allele was quite high, depending on the ethnic group analyzed [18-21]. Some authors suggested that the homozygosity for ... 5-methyltetrahydrofolate as a carbon donor [6] . This donor is synthesized by the methylenetetrahydrofolate reductase (MTHFR) gene from 5,10-methylene-tetrahydrofolate [9,10]. Reduction in the ... Frequency of the MTHFR genotypes and the result of the Chi square testing in the different studied groups. Showing the frequency and the results of the cross tabulation of the T allele and the different...
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Tài liệu Báo cáo khoa học: "Selecting the “Right” Number of Senses Based on Clustering Criterion Functions" pdf
... single threshold. The graph of the P K1 scores shown in Figure 1 illustrates the dif-ficulty - the slope of these scores is nearly linear,and as such the threshold (as shown by the hori-zontal line) ... solutions for all values of k from 1 N , and then determines the mean andstandard deviation of the criterion function. Then,a score is computed for each value of k by sub-tracting the mean from the ... many cases several clusters off of the cor-rect value. While P K2 made various mistakes,it was generally closer to the correct values, andhad fewer spurious responses (very large or verysmall...
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Tài liệu Báo cáo khoa học: "Choosing the Word Most Typical in Context Using a Lexical Co-occurrence Network" ppt
... program to the baseline of always choosing the most frequent synonym according to the training corpus. But what are the 'correct' responses? Ideally, they should be chosen by a credible ... Ph.D. the- sis, University of Toronto. Yarowsky, David. 1992. Word-sense disambiguation using statistical models of Roget's categories trained on large cor- pora. In Proceedings of the1 4th ... sentence provides for choosing a candidate word is the sum of the significance scores of each co-occurrence of the candidate with a word IOur training corpus was the part -of- speech-tagged 1989...
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