... Genome Biology 2009, 10:R25
Open Access
2009Langmeadet al.Volume 10, Issue 3, Article R25
Software
Ultrafast and memory-efficient alignment of short DNA sequences
to the human genome
Ben ... properly cited.
Bowtie: short- read alignment& lt;p>Bowtie: a new ultrafast memory-efficient tool for the alignment of short DNA sequence reads to large genomes....
... of human CENP-A was used as
the template for the commercial synthesis of synthetic
peptides (Peptides & Elephants, Berlin, Germany). The
quality and purity of the peptide were assessed by ... of SSc patients. Therefore, no infor-
mation was obtained for the clinical sensitivity of the
peptide based assays. Another limitation of the study was
the lack of d...
... antiinflammatory properties [36] and, therefore,
ED7
+
AM seem to play a role in the control of the inflam-
matory reaction. On the other hand these ED7
+
AM also
produce higher amounts of IL-12, a cytokine ... clearly suggest that the newly recruited ED7
+
AM
are involved in the regulation of the ongoing inflamma-
tory process. Whether the antiinflammatory effects...
... IF
IF
LY
LY
P Y E L Y G L
DP
DP
RPL
PL
D K F F LY
LY
P Y E L Y G L
DP
DP
RPL
PL
D F IF
IF
LY
LY
P L Y G L
DP
DP
RPL
PL
D K F IF
IF
LY
LY
P Y E L Y G L
DP
DP
RPL
PL
D K F IF
IF
LY
LY
P Y E L Y G ... L
FYNVTYT A YRLS FGF EYSNL TEIG KKLT RF RY G TDRT GYFTN STRF
LLHKQWT L YSLT YKF SYSN- KEYSR L NA FIVAE KQ K LAVE V
LLHKQWT I YSLT YKF SYSN- KDYSR L SA FIVAE KQ K VAVE V
LLSKQWT L...
... signals in the genome and to uncover
underlying gene-regulatory mechanisms. Sequence analysis
to identify conserved cis-regulatory signals is typically aug-
mented by at least one of two types of information: ... motifs within the
upstream and the coding regions of the genome, respectively,
as computed by MAST (Motif Analysis and Search Tool) [15].
In order to normal...
... <0.01)
measured by: (1) the physical distance (in kilobases)
from the SNP to the center of the hotspo t; and (2) the
number of SNPs between the candidate SNP and the
proximal boundary (also a SNP) of the ... in
Additional file 3), the vast majority of random P-values
are uniformly distributed, indicating that they correspond
to the truly null hypothesis....
... transcription factors and their target
DNAs. The enhancer or cis-regulatory module is the focal
point of integration for many of these regulatory events.
Enhancers, which usually span 0.5 to 1.0 kb, ... information
Genome Biology 2007, 8:R75
into the function of these 'evolutionarily hardened' sequences
and ultimately produce a better understanding of the reg...
... of the manuscript. MC contributed to
analyze and interpret the data and to write the manuscript. LK participated
to the study design, analysis and results interpretation and writing-up of the
manuscript. ... and because of the
inability to admit the casualties, they were referred to
yet a second city“ according to another interviewee.
The lack of...
... substantial contributions to conception and design, and to the analysis and
interpretation of the data. TRM and GWC handled acquisition of data. All authors contributed
to the manuscript revision ... on the prevalence in the
population, and more reflective of the test itself, lessening the impact of any unique features of
the VA population. Moreover...
... only to the extent that they
are limited to the peribronchial and perivascular
spaces. There is recruitment of T and B lymphocytes
as well as dendritic cells, but there does not appear to ... found to be suffi-
cient to drive autoimmune diabetes [26]. Most of the
inflammatory responses described above arguably
fall into the category of Th1-mediated effector me...