... mediates Myc autorepression and its tran-
scriptional control at many loci. In this study the authors used
the Gal4 UAS system to express ectopic dmyc in embryos and
performed microarray analysis to ... cuticle
hydrolase activity
transferase activity
ion transporter activity
carrier activity
structural constituent of cytoeskeleton
microtubule motor activity
nucleoside binding
hydrolas...
... Tschopp J: Inflammatory caspases: linking an intra-
cellular innate immune system to autoinflammatory
diseases. Cell 2004, 117:561-574.
33. Martinon F, Tschopp J: Inflammatory caspases and inflammas-
omes: ... activates transcription factors such as nuclear factor-κB (NF-κB) and interferon
regulatory factors (IRFs) that ultimately lead to tumor necrosis factor (TNF) and type I interferon...
... including
mature parasite-infected erythrocyte surface antigen (MESA
- known to bind to the erythrocyte membrane cytoskeleton)
http://genomebiology.com/2005/6/11/R93 Genome Biology 2005, Volume 6, Issue 11, ... the erythrocyte mem-
brane and mediate cytoadhesion to human receptors exposed
to circulating parasites. PfEMP1 proteins are encoded by var
genes, and field isolates possess ap...
...
Palaeontology and Geology, East Beijing Road, Nanjing, Jiangsu 210008, PR China.
¤ These authors contributed equally to this work.
Correspondence: Junfeng Zhang. Email: jfzhang@nju.edu.cn. Chen-Yu ... microarray hybridization and array scanning
were performed as previously described [21]. Briefly, 25 μg of
total RNA was used to isolate the low molecular weight RNA
using polyethy...
... study design will need to be
addressed when future investigators examine this issue. A
classic case–control methodology should ideally be
employed, matching controls for sex, age, case type (e.g.
surgical ... patients, multivariate
analyses to determine the independent effect of extubation
failure are mandatory.
How should the results of this study and other studies
conducted in terti...
... in yeast, where
autophagy seems only to be dependent on TOR.
RNAi screens can also identify novel components in bio-
logical processes. Dan Durocher (Samuel Lunenfeld Research
Institute, Toronto, ... sensitivity to serotonin, a neurotransmitter that
has been associated with psychiatric disorders in humans.
She described the discovery of three genes - one conferring
hypersensitivity to s...
... that
transcription is regulated. This is made abundantly clear by
the study from the FANTOM Consortium and the Riken
Omics Science Center [11], which modeled the
transcriptional regulatory networks of a differentiating
human ... controlled by a
small number of ‘master regulators’.
A similar strategy could be applied to identify transcription
factors involved in regulation of other develo...
... patient safety
measure. A potential benefit of implementing an MET is the
capacity to systematically assess preventable adverse events,
which are defined as poor outcomes caused by errors or system
design ... Emergency Teams (METs), alternatively known as
Rapid Response Teams, have recently been implemented in
many hospitals worldwide [1]. The primary role of an MET is to
improve the earl...
... mainly cytostati-
cally compared with classical cytotoxic drugs require
special timing of scans [68]. International guidelines
for PET tests are therefore necessary to guarantee the
quality and ... conditions, are likely
to play a key role in future clinical cancer treatment.
Table 2. Tumor types for which FDG-PET assays are used
to assess tumor response to cancer drug therapy...
... Introduction
Cystatin C (Cys-C) is a non-glycosylated cationic
protein of 13.3 kDa, belonging to the cystatin superfamily
of cysteine protease inhibitors [1, 2]. Cys-C is produced
by all nucleated ... of
the steady-state serum trough concentrations of digoxin in Japanese patients. Forty patients treated with digoxin
and 56 healthy elderly subjects were participated in this study. Th...