Báo cáo sinh học: "AAV-mediated gene therapy for metabolic diseases: dosage and reapplication studies in the molybdenum cofactor deficiency model" pps
Báo cáo sinh học: "AAV-mediated gene therapy for metabolic diseases: dosage and reapplication studies in the molybdenum cofactor deficiency model" pps
... not for citation purposes)Genetic Vaccines and Therapy Open AccessShort paperAAV-mediated gene therapy for metabolic diseases: dosage and reapplication studies in the molybdenum cofactor deficiency ... jreiss@gwdg.de* Corresponding author Abstract In a mouse model for molybdenum cofactor deficiency as an example for an inherited metabolic disease we have determined the dosage of recombinant AAV necessary ... Harkins RN: Effect of viral dose on neutral-izing antibody response and transgene expression afterAAV1 vector re-administration in mice. Gene Ther 2008,15(1):54-60.Genetic Vaccines and Therapy...
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báo cáo khoa học: " Years of life lost to prison: racial and gender gradients in the United States of America" pps
... life tableinto these two states using prevalence of imprisonment bygender and race. These figures were then used to compute the life table value of the total remaining years of life and the corresponding ... and SAS initiated the study. RSH and EFDcollected and analyzed the data. All authors contributedto the writing of the manuscript. All authors reviewed the final manuscript for important intellectual ... enforcement strategies generally and drug policy in particular.Competing interests The author(s) declare that they have no competing inter-ests.Authors' contributionsRSH, SB, ED, and...
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Báo cáo sinh học: "Is gene therapy a good therapeutic approach for HIV-positive patients?" pot
... molecular and genetic age of med-icine, research to create gene therapy for HIV has been on the rise. Since the 1980's, researchers have explored the possibility of using gene therapy to ... HIV-positive twin was the recipient. T cells from the donor were genetically modified ex vivo to express CD4ζ and then transfused into the recipient twin. The study wasperformed in two phases. In the first ... dawn.wooley@wright.edu* Corresponding author AbstractDespite advances and options available in gene therapy for HIV-1 infection, its application in the clinical setting has been challenging. Although published...
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Báo cáo sinh học: " Reference gene selection for quantitative real-time PCR analysis in virus infected cells: SARS corona virus, Yellow fever virus, Human Herpesvirus-6, Camelpox virus and Cytomegalovirus infections" doc
... safety and convenience for the precise monitoring of viral load in clinical material, aswell as for the investigation of the expression of cellulargenes in response to virus infection. However, the ... to be the best refer-ence genes in virus infected cells. These genes are a goodpoint to start reference gene selection in gene expression studies in virus infection experiments.Material and ... reference gene in virus infectedcells. The actin gene shows significant variations withincreasing degree of infection. The best genes obtained from all three calculation toolswere TBP and PPI....
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báo cáo sinh học:" Equity-oriented toolkit for health technology assessment and knowledge translation: application to scaling up of training and education for health workers" pptx
... inform policy-making about optimizing the supply, improving the distribu-tion, increasing the efficiency and enhancing the perform-ance of health workers. Geneva 2006.27. Institute for Health Improvement: ... Organization of Migration.PW is the Coordinator of the Technical Working Groupon the Task Force for Scaling Up Education and Training for Health Workers, Global Health Workforce Alliance.BioMed CentralPage ... to theirtraining as required, and that training is accessible tothose who need it. The toolkit provides tools that can beused to determine which educational and training inter-ventions for...
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Báo cáo sinh học: " Sensitivity of methods for estimating breeding values using genetic markers to the number of QTL and distribution of QTL variance" ppsx
... size of the training popula-tion increased and when t he number of markersincluded in the data increased (Table 7). In a normalsituation, where the size of the training population was500 individuals, ... After n steps,therearenmarkersinthemodel.Weusedthelarsfunction in the lars p ackage [21] of R and used crossvalidation on the training data to find the number ofmarkers that minimized prediction ... recordedincluded the time required to fit the model on the train-ing population, the time required for cross validationwhen using LARS and PLSR, and the time required tocalculate MEBV for the evaluation...
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Báo cáo khoa học: A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles pdf
... organelles.Therefore it could be used to study the involvement of these proteinases in protein degradation and the processing of invariant chain. An assay combi-ning a new monospecific CatE antibody and ... of the peptide, the quenchingefficiency is decreased, resulting in an increase in fluorescence. The activity determined in subcellularfractions was completely inhibited by pepstatin A.Therefore, ... 2007)doi:10.1111/j.1742-4658.2007.05846.xCathepsin E (CatE) and D (CatD) are the major aspartic proteinases in the endolysosomal pathway. They have similar specificity and therefore it isdifficult to distinguish between them, as...
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Báo cáo sinh học: " Characterization of vaccinia virus A12L protein proteolysis and its participation in virus assembly" pptx
... placed into pRB21 and appended with a C-terminal FLAG epitope (FC). The N-terminal AG/A site and internal AG/K site mutations, the N-terminal AG/A and C-terminal AG/K site mutations, and the internal ... Coomassie staining. The four bands in molecular weights of 20, 15, 13, and 11 kDa were cut out and sent for N-terminal sequencing. The sequence data we obtained from N-terminal sequencing is represented ... of A12L. In order to characterize the proteolytic processing of A12L, we examined the utilization of each AG/X site and determined the responsible proteinase for the processing. A. The A12L...
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Báo cáo sinh học: "Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells" doc
... study indicating that ERK2binds to the α-chain of the IFN α/β receptor and STAT1[34], and JAK2 may be required for MAP kinase pathwayactivation [35]. Furthermore, HCV proteins such as NS5Ainteract ... kinase in TypeI interferon signaling. J Biol Chem 2004, 279(2):970-979.17. Platanias LC: The p38 mitogen-activated protein kinase path-way and its role in interferon signaling. Pharmacol Ther ... activity and Stat1 phosphor-ylation in the presence of MAPK inhibitors and dominantnegative mutants. We performed ISRE reporter gene experiments with IFN-α and alcohol treatments in the presence...
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Báo cáo sinh học: " Research Article Estimation of Time-Varying Coherence and Its Application in Understanding Brain Functional Connectivity" potx
... be studied and will be further considered in the future.7. Conclusions In this paper, we investigate the estimation of the time-varying spectrum and the time-varying coherence for the locally ... eliminate the nonstationarity.On the other hand, in many applications, nonstationarycharacteristics of a signal are of great interest. For example, in neural information processing, the brain ... function. The locally spectral information can be approximatedby combining the operations of averaging Γxx(t, τ)along the t direction and then applying Fourier transform along the τ direction within...
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