... strongly reduced in RA, and splitting patient samples into non-inflammatory and inflammatory by C-reactive protein levels reveals the reduction is predominantly observed in inflammatory RA [55].Although ... high in RA patients [8,57]. As the methotrexate- and deoxyco-formycin-based therapies act as anti-inflammatory agents byincreasing extracellular adenosine and blocking ADA,respectively, the ... in the synovium infiltrate, strongly express the chemokine receptorsCXCR3, CXCR4, CXCR6 and CCR5, which all bind pro-inflammatory chemokines. SDF-1 is important for retainingcells in the inflamed...