Báo cáo y học: "A genome-wide approach to identify genetic loci with a signature of natural selection in the Irish population" pps
Báo cáo y học: "A genome-wide approach to identify genetic loci with a signature of natural selection in the Irish population" pps
... genome-wide approach to identify genetic loci with a signature of natural selection in the Irish populationValeria Mattiangeli*†, Anthony W Ryan†‡, Ross McManus†‡ and Daniel G Bradley*Addresses: ... evidence of selection. In addition to the demonstrated utility in detecting a signature of natural selection, this approach has the particular advantage of speed. Italso illustrates concordance between ... statistic. Interestingly, a recentanalysis has stated evidence of recent selection associated with a variation (V470) that is in linkage disequilibrium with haplotypes that are not associated...
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Báo cáo y học: " An integrated approach to diagnosis and management of severe haemoptysis in patients admitted to the intensive care unit: a case series from a referral centre" ppsx
... period and may provide a useful frame-work for the therapeutic management of haemoptysis in this clinical setting. To summarize, a multidisciplinary approach remains the cornerstone for the management ... associated with attempting a first-line bronchial arteriography. This approach was applicable to 75% of our patients and led to an immediate control of bleeding in more than 80% of them. Although the ... of standardisation for quantifying it, since it is known to berelated to death [5]. Respiratory failure, a substantial drop of haemoglobin level, and haemodynamic failure allobviously mandate...
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Báo cáo y học: "n alternative approach to combination vaccines: intradermal administration of isolated components for control of anthrax, botulism, plague and staphylococcal toxic shock" docx
... performed using Adobe PhotoShopsoftware.Statistical analysisAnalysis of variance was used to analyze serology dataobtained at various time points after vaccine administra-tion to determine if there ... studies of all ani-mals. LSM contributed the botulinum toxin vaccine andanalyzed data from the botulism study. JBA performed the vaccinations and analyzed data. JAM participated in the design of the ... and panniculus at the injectionsite and the phagocytes contained abundant intracyto-plasmic blue-gray granular material (Fig. 1C). Histochem-ical staining of the tissue with Morin, a dye that...
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Báo cáo y học: "Evidence-based approach to intensive care unit management: need for improvement" potx
... accompanied by a high desire among ICU staff to leave their work, indicatingthat immediate actions are needed to adapt the critical careorganisation to new professional demands, to the increasingworkload ... oneself inadequately equipped with the necessarytools and training is very unfortunate and uncomfortable foran otherwise highly competent individual, and not least forstaff and patients alike. ... effort and research are needed to define the skills required for leading and managing an ICU,and it is appropriate to develop training programmes wherethose capabilities are enhanced and trained.LetterEvidence-based...
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Báo cáo y học: "Skin Test Reactivity to Indoor Allergens Correlates with Asthma Severity in Jeddah, Saudi Arabia" docx
... in that of perennial asthma, and a Original ArticleSkin Test Reactivity to Indoor AllergensCorrelates with Asthma Severity in Jeddah, Saudi ArabiaEmad A. Koshak, MD, FRCPSCAbstractBackground: ... one of the probable causes forincreases in the prevalence of asthma. This indoorlifestyle may have led to either an increased expo-sure to allergens or an increase in factors that enhance the ... induction of allergyand elicitation of allergic disease. Allergy1998;53:115–20.26. Liccardi G, Cazzola M, D’Amato M, D’AmatoG. Pets and cockroaches: two increasing causes of respiratory allergy in...
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Báo cáo y học: "Innovative combination strategy to enhance effect and diminish adverse effects of glucocorticoids: another promise" pot
... fully synonymous with inflammatory and immunosuppressive activity and with adverse effects, respectively. For instance, hypopituitary-pituitary-adrenal axis suppression and increased risk of infection ... compared with the natural cortisol. The synthetic glucocorticoid deflazacort (anoxazoline derivative of prednisolone) was claimed to have the same anti-inflammatory and immunosuppressive activity ... effects and adverse effects are manifold.Ultimately, the proof of the pudding is in the eating. Com-parative clinical trials of long duration with adequate numbers of patients and regular assessments...
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Báo cáo y học: "Modulated contact frequencies at gene-rich loci support a statistical helix model for mammalian chromatin organizatio" ppsx
... interaction.Since this modulation was similar at all loci investigated,we plotted all the data into a single graph (Figure 2a) . Sta-tistical analyses indicated a significant increase of randomcollision ... However, data obtained in GC-richdomains are fully compatible with a statistical helix organization.Compared to mammals, chromatin dynamics in yeast can be describedas a statistical helix that would ... experimentalpoints were obtained from a highly quantitative methodand combined together into a sing le graph after accuratenormalization of the data [19]. Secondly, at many gene-rich loci (see,...
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Báo cáo y học: "Open Access Substance abuse and psychiatric co-morbidity as predictors of premature mortality in Swedish drug abusers a prospective longitudinal study 1970 - 2006" docx
... non-substantial, as they were related to con-tributing and not underlyingcausesofdeath,andthefinal coding was based on a mutual agreement.Drug related deathDeath was drug related in 120 of 204 deaths ... of drug abusers the increase of co-morbidity reflected the more systematic application of diagnostics rather than a general increase in prevalence rates [38].Two patterns remained in the analysis; ... enteredtreatment amphetamine was the single most commonsubstance of abuse in Sweden nationally as well as in the local area, where 35-45% of the drug abusers hadamphetamine as the most prevalent...
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Báo cáo y học: " Quantitative PCR used to Assess HIV-1 Integration and 2-LTR Circle Formation in Human Macrophages" potx
... detection of HIV-1 i ntegration; meanwhile, b-galactosidase activitywas analyzed for determination of HIV-1 infection. Asshown in Figure 1A b-galactosidase activity in raltegrav irtreated cells with ... very important, particularly regarding the effect of HAART in HIV-1 infected individuals. Because of limitations of prior HIV-1 integration assays, there is limited data on the level of integration ... Kelleher AD, Law M, Chen J, Hazuda DJ, Nguyen BY,Teppler H, Cooper DA: Antiretroviral therapy with the integrase inhibitorraltegravir alters decay kinetics of HIV, significantly reducing the secondphase....
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Báo cáo y học: "Commonly applied positive end-expiratory pressures do not prevent functional residual capacity decline in the setting of intra-abdominal hypertension: a pig model" pot
... ety of Abdominal Compartment Syndrome as a sustained increase in intra-abdominal pressure (IAP)above or equal to 12 mmHg and abdominal compartmentsyndrome is defined as an IAP of more than ... inter-nal jugular vein to allow the placement of a pulmonaryartery catheter (AH-05050, Arrow International) undercontinuous pressure wave monitoring into the pulmon-ary artery in order to measure ... CO.Intra-abdominal pressure measurement and generationFor the measurement of IAP, a caudal midline laparo-tomy was performed to p lace a 12F Foley catheter(226512, Bard, Covington, GA, USA) in...
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