Báo cáo y học: "Nonrandom divergence of gene expression following gene and genome duplications in the flowering plant Arabidopsis thaliana" doc
Báo cáo y học: "Nonrandom divergence of gene expression following gene and genome duplications in the flowering plant Arabidopsis thaliana" doc
... Arabidopsis thaliana, we show that the mode of duplication, the function of the genes involved, and the time since duplication play importantroles in the divergence of gene expression and, therefore, ... and small-scale gene duplication events by means of microarray data and investigate both the influence of the origin (mode of duplication) and the function of the duplicated genes on expression divergence. Results: ... duplicated genes and N is the number of samples. In evaluating and comparing the dis-tributions of the correlation coefficients of the expression of aset of genes, we used the Mann-Whitney U test...
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Báo cáo Y học: Amphipathic property of free thiol group contributes to an increase in the catalytic efficiency of carboxypeptidase Y pot
... thiol group (Cys341) is involved in substrate binding at the S1 subsite and in maintaining the width and depth of the S1 subsite; (b) the rearrangement of the S1 subsite induced by the interaction ... for the hypothesis that Cys341 is not only located at the S1binding site [5–7,9], but the hydrophobicity of the thiolgroup also plays a role in substrate binding and interacting with the hydrophobic ... DG‡ðmutantÞÀDG‡ðwild-typeÞwhere DGsis the binding energy of the substrate to the enzyme, DGàis the activation energy in the chemical steps of bond making and breaking, DG‡Tis the activation energy forthe...
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Báo cáo y học: "Decreased levels of soluble amyloid β-protein precursor and β-amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus" ppsx
... 23:57-63.18. Yeh TS, Wang CR, Jeng GW, Lee GL, Chen MY, Wang GR, Lin KT,Chuang CY, Chen CY: The study of anticardiolipin antibodies and interleukin-6 in cerebrospinal fluid and blood of Chinesepatients ... would be of value to improve the clinical evaluation of NPSLE and to study the ongoing brain parenchyme status in living subjects with NPSLE. In the current study, we found significantly decreasedlevels ... rheumatologist, neurologist and neu-ropsychologist. Examination of the CNS signs and symp-toms included lumbar puncture, neuropsychological tests and MRI of the brain. Nine of the patients underwentlumbar...
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Báo cáo y học: "Direct interaction of immunoglobulins with synovial fibroblasts: a missing link in the pathogenesis of rheumatoid arthritis" potx
... article by Terry Smith and William Cruikshank in the Journal of Immunology provides fascinating yetunexpected insights into how autoantibodies contribute to the maintenance of inflammatory disease ... chronic inflammation (both local and systemic), and alterations in the immune response, including changes in the T-cell repertoire and the production of autoantibodies[1]. The precise nature of these ... activity and T-cell trafficking. In addition,they are of potential importance for the development of innovative therapeutic strategies, in which interrupting the IGF-1/IGF-1R axis could result in...
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Báo cáo y học: " Elevated risks of death for diabetes mellitus and cardiovascular diseases in Italian AIDS cases" pps
... numbers of DM, myocardial infarction, and chronic ischemic heart diseases as underlying cause of death in PWA with the expected numbers from the sex- and age-matched, general population of Italy. The ... shown).DM and cardiovascular diseases were the underlyingcause of death of 43 PWA (i.e., they cause 1.4% of alldeaths): 14 deaths were caused by DM, 17 by myocardialinfarction, and 12 by chronic ... mortality of Italian AIDS cases in the post-HAART era. However, the risks of death were remarkably higher than in the corre-sponding general population. We have used mortalityrates in the general...
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Báo cáo y học: "Prognostic factors of atrial fibrillation following elective coronary artery bypass grafting: the impact of quantified intraoperative myocardial ischemia" pptx
... undergoing coronary artery bypass grafting(CABG) [1-3] and in 30-63% of those oper ated forcoexisting ischemic heart and valve disease [3,4]. The majority of AF arrhythmias appear within the first ... de-clamped. Just after discontinuation of cardi-opulmonary bypass and thereafter, in the ICU, a fluid-balance was daily recorded. During the ICU-stay and later on, in the ward, the ratio FiO2/pO2was ... indices of myocardial infarction The levels of serum myocardi al enzymes (CK, CK-MB)were daily checked after surgery. Troponin I levels werenot routinely checked. The diagnosis of myocardialinfarction...
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Báo cáo y học: "Early Induction of apoptosis with tobacco smoke and related products in A549 lung epithelial cells in vitro" potx
... reduction in mitochondrial cytochrome C and an increase in cytosoliccytochrome C. At the same time point, hydrogen peroxide and CSE significantly increased the concentration of Bax-α in the mitochondria.Conclusion: ... Pryor WA: The free radical chemistry of cigarette smoke and their interaction of alpha-1-proteinase inhibitor. In Pulmonaryemphysema and proteolysis Edited by: Taylor JC, Mittman C. New YorkAcademic; ... morphology after exposure to tobaccosmoke and the other treatments used, showed that many of the cells detached from the culture flask confirming the findings of others [6]. The observation, in the...
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Báo cáo y học: "Differential cytopathogenesis of respiratory syncytial virus prototypic and clinical isolates in primary pediatric bronchial epithelial cells" pdf
... unlikely to explain the differential growth kinetics and, by extension, the cyto-pathogenesis of the prototypic RSV A2 strain and the clinical isolates.Differential chemokine/cytokine secretion following ... with data analyses. JPM supervised the clinical and bronchial sampling aspects of the study and the study feasibility. PVC inputto study design and was responsible for the screening of all patients ... have not, or only poorly, adapted in limited passageson HEp-2 cells. Indeed, a relatively low binding affinity toHS might explain the limited infectivity of the clinicalisolates in our PBEC model....
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Báo cáo y học: "No influence of oxygen levels on pathogenesis and virus shedding in Salmonid alphavirus (SAV)challenged Atlantic salmon (Salmo salar L.)" pot
... seen in experimental tank systems. In addition, information is lacking regarding the route of virus entry/exit and the virus dose necessary to elicit aninfection. Our findings that SAV shedding ... nor-malized against endogenous (EF1AA)- and exogenousreference genes (Sal- and VHSV-assays) by the use of the Microsoft®Excel® based computer software Q -Gene [47]. The resulting mean normalized expression (MNE)-values ... 14during experimental SAV-infections. Histopathologicalfindings associated with infections by all subtypes of SAV are very similar [11,12], and may include severedegeneration of exocrine pancreas...
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Báo cáo y học: " Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs" doc
... Probes,Eugene, OR, USA). Sulphated glycosaminoglycan (sGAG)content was determined using the 1, 9-dimethyl-methyl-ene blue dye-binding assay in agarose/papain digests and media samples and the values ... were inhibitedby dynamic compression or by the presence of the iNOSinhibitor, linking reparative activities by both types of stimuli. Future investigations which examine the signal-ling cascades ... fibronectin fragments and increase the production of NO, cytokines and MMPs. Catabolic activities were downregulated by dynamic compression or by the presence of the iNOS inhibitor, linking reparative...
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