Báo cáo y học: "Explicit equilibrium modeling of transcription-factor binding and gene regulation" pdf
Báo cáo y học: "Explicit equilibrium modeling of transcription-factor binding and gene regulation" pdf
... experimentally,for example by binding site selection [29] or by computa-tional analysis of co-regulated genes [2,30,31], or by a combi-nation of selection and computational analysis [23].Typically, ... cooperative binding of proteins X and Y to DNA can beseparated thermodynamically into the formation of an XYdimer and the binding of that dimer to DNA; this is thermo-dynamically equivalent ... R87MethodExplicit equilibrium modeling of transcription-factor binding and gene regulationJoshua A Granek*† and Neil D Clarke*‡Addresses: *Department of Biophysics and Biophysical Chemistry, Johns...
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Báo cáo y học: "Predictive network modeling of the highresolution dynamic plant transcriptome in response to nitrate" pps
... 15, and 20 minu tes are 63 (76% of regu-lated genes), 146 (76% of regulated genes), 54 (98% of regulated genes), 123 (82% of regulated genes), 164 (87% of regulated genes), and 209 (92% of regulated ... uponperturbation. Such dynamical models essentially consist of a mathematical function that governs the transitions of the state of a gene regulatory network over time.Typically, dynamical models of mRNA concentrationsconsist ... (seeMaterials and methods) between each pair of gene lists.The lists included genes regulated by NO3-across each of the six time points (our study), and lists of genesregulated by seven different...
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Tài liệu Báo cáo Y học: Biphasic reductive unfolding of ribonuclease A is temperature dependent pdf
... image analysis,which is established by us recently [4,11], was used toanalyze the unfolding dynamics and also was introducedinto the analysis of the thermal transition study by CD and 1HNMR.MATERIALS ... mutants of bovine pancreatic ribonuclease Amissing the 65–72 disulfide bond: characterization of a minorfolding pathway of ribonuclease A and kinetic roles of Cys65 and Cys72. Biochemistry 37, ... selectivity of the breakage of the first disulfide may be altered by the different cystinesurface exposures induced by temperature and dithiothre-itolredconcentration.Another possible explanation of...
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Tài liệu Báo cáo Y học: NMR-based determination of the binding epitope and conformational analysis of MUC-1 glycopeptides and peptides bound to the breast cancer-selective monoclonal antibody SM3 pptx
... fragment of the ligand of the X-ray structure (RCSB PDB entry 1SM3). After smallmanual corrections, t he ligands were docked into the binding site of SM3 using theFLEXIDOCKmodule of t heSYBYLsoftware ... monoclonalantibody SM3, which is being tested for its diagnostic utility.We used NMR spectroscopy to analyze the binding mode and t he binding epitope of peptide and glycopeptide antigensto the SM3 antibody. ... Paulsen1, Joy M. Burchell2, Joyce Taylor-Papadimitriou2 and Bernd Meyer11Institute of Organic Chemistry, University of Hamburg, Germany;2Imperial Cancer Research Fund Breast Cancer Biology Group,Guy’s...
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Báo cáo y học: "The factor structure of the Strengths and Difficulties Questionnaire (SDQ) in Greek adolescents" potx
... Equation Modeling 1999, 6:1-55.39. Nunnally JC, Bernstein IR: Psychometric theory. New York, USA:McGraw-Hill Book Company; 1994. Annals of General Psychiatry 2009, 8:20 http://www.annals-general-psychiatry.com/content/8/1/20Page ... 2Department of Child and Adolescent Psychiatry, Athens University Medical School, "Agia Sophia" Children's Hospital, Athens, Greece and 3Department of Psychiatry, Community Mental ... properly cited.Annals of General Psychiatry 2009, 8:20 http://www.annals-general-psychiatry.com/content/8/1/20Page 5 of 7(page number not for citation purposes)education sample reported many deviations...
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Báo cáo y học: " A promoter haplotype of the interleukin-18 gene is associated with juvenile idiopathic arthritis in the Japanese population" pps
... the polyarthritis and systemic subgroups, thefrequency of haplotype S01 did not differ statistically from that of healthy controls. The frequency of haplotype S01 was alsosignificantly higher ... fre-quency of haplotype S01 of the IL18 gene is 37.9% and that of the S01/S01 diplotype configuration is 13.9% in the Japa-nese population. We also estimated the frequency of haplo-types and/ or ... liver dysfunction, splenomegaly and hyper ferritinemia [12]. Although serum levels of inflammatorycytokines are generally high in AOSD patients [13], the levels of IL-18 were enormously high,...
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Báo cáo y học: "Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation" pot
... OA and ND chondrocytes, and only 184 geneswere differentially regulated.Conclusions Only few genes were differentially expressedbetween OA and ND chondrocytes in Hyaff-11 culture. The risk of ... high-density pellet and scaffold (Hyaff-11)cultures by histological proteoglycan assessment (Bern Score) and immunohistochemistry for collagen types I and II.Chondrocytes cultured in monolayer and ... chondrocytes; scaffold and monolayer cultures from OA chondrocytes; chondrocytes from OA and ND cultured in monolayer; and scaffolds cultures. Genes were functionally filtered by annotations of...
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Báo cáo y học: "Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network" pps
... network;GO: Gene Ontology; GS: gold standard; GSP: gold standardpositive; GSN: gold standard negative; GN: gene neighbour;HPRD: Human Protein Reference Database; KEGG: KyotoEncyclopaedia of Genes and ... willsubsequently refer to this set of 334 genes as 'ObesHancock'genes. There is no overlap between the 24 OMIM obesitygenes and the 334 ObesHancock genes. Here, we rank obes-ity-related genes ... of infinity and ranked on the top. Next, we plot a ROC curve of sensitivity versus 1 - specificity on how well the disease IIgenes are ranked in the sorted gene list. Sensitivity and (1 -specificity)...
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Báo cáo y học: " Contrasting chromatin organization of CpG islands and exons in the human genome" pot
... density of H3K36me3does not show exon-specific enrichment. My hypothesisis as follows. The relative density of H3K36me3 differsbetween highly and lowly expressed genes. It is the den-sity of ... methylation patterns and epigenetic memory. Genes Dev 2002, 16:6-21.26. Yamada Y, Watanabe H, Miura F, Soejima H, Uchiyama M, Iwasaka T, Mukai T, Sakaki Y, Ito T: A comprehensive analysis of ... 11:R70http://genomebiology.com/2010/11/7/R70Page 5 of 8As the methylation data used here were generatedbased on the affinity of methylation -binding proteins, it ispossible that high CpG density on exons...
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Báo cáo y học: " An exploratory survey of money boys and HIV transmission risk in Jilin Province, PR China" potx
... thatrural money boys may increase condom usage aftermigrating to large cities [17]. The very nature of the MBtrade would imply that they seek multiple sexual part-ners, and may yield to client ... suggest thatmigrants may not necessarily be at the heart of moneyboy activity in Jilin Province. This finding is potentiallyimportant, since there is always a danger of increasedsocial discrimination ... were very highlevels of sexual activity. The average price of either oral oranal sex services in the province is only 100-200 yuan(approximately US$14.00-$28.00). However, frequency of sexual...
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