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Báo cáo y học: "A computational method to predict genetically encoded rare amino acids in proteins" pdf

Báo cáo y học:

Báo cáo y học: "A computational method to predict genetically encoded rare amino acids in proteins" pdf

... to incorporate two additional amino acids with distinct functionality, selenocysteine and pyrrolysine. These rare amino acids canbe overlooked inadvertently, however, as they arise by recoding ... read-throughcases.Putative pyrrolysine recoding in archaeaThe RSA method was also used to search for proteins poten-tially containing the pyrrolysine residue, the so-called 22nd amino acid (Table 2). The pyrrolysine ... genetically encoded rare amino acids (RAAs) are selenocysteine and pyrrolysine,the proposed 21st and the 22nd amino acids, respectively [3-7].Selenocysteine, a selenium-analog of cysteine, is a potentnucleophile...
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Báo cáo y học: " A rapid method to screen putative mRNA targets of any known microRNA" pdf

... unexpressedmRNAs in certain cells will be predicted to be t argetsby Bioinformatics. Hybrid-PCR has much more flexibil-ityandcanbeusedtoidentifytargetmRNAsforamiRNA from any kind of cells at ... rine sample of a 5-month-old infant hospitalized in Shengjing Hospital of China Medical University. Hanstrain was p assa ged six t imes in human embryonic lungfibroblasts (HELF) maintained in ... efficiency of hybrid-PCR in screening putative targets could be confirmed by usingthose targets as references.ResultsmiRNAs play the role of posttranscriptional regulationby binding to target...
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Báo cáo y học:

Báo cáo y học: "A novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigens" pptx

... mixture of baits.For example, intravenously administered phage displaylibrary has been successfully used for in vivo bio-panning in certain animal model systems to identify tissue-specificpeptide ... synthetic biotinylated TMGpeptide (Fig. 1C, TMG). Conversely, phages displaying theTMG peptide bind to a synthetic biotinylated DSP peptide(Fig. 1C, DSP). In the absence of biotinylated peptides, ... Bond*†1Address: 1Moyne Institute for Preventive Medicine, Department of Microbiology, University of Dublin, Trinity College, Dublin 2, Ireland, 2Institute of Immunology & Department of Biology, National...
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Báo cáo toán học: "A New Method to Construct Lower Bounds for Van der Waerden Numbers" pdf

... presented a way to expand the size of a certificate by zipping. Combining theexisting knowledge to create cyclic certificates with this zipping technique resulted in theCyclic Zipper method. Using this ... constraints we refer to [4].By using additional constraints - also known as streamlining [7] or tunnelling [11] -patterns can be forced to reduce the search space. Point symmetry can be forced by ... coloring.4.3 ZippingUsing the zipping technique, one can expand an existing cyclic certificate into a cycliccertificate of multiplied size. The basic concept is to zip two certificates into each...
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Báo cáo y học: "A novel approach to measure the contribution of matrix metalloproteinase in the overall net proteolytic activity present in synovial fluids of patients with arthritis" pptx

... the inflammatory state of the diseaseExtracellular proteases are secreted in SF by infiltrating inflam-matory cells and/or by stromal cells stimulated by inflammatorycytokines [21,22]. To ... proteolytic activity. This suggests that, in thecase of arthritis with involvement of several joints, systemicfactors play a dominant role in controlling the local proteolyticactivity. Finally, ... 1Proteolytic activity in synovial fluid of patients with osteoarthritis and inflammatory arthropathiesProteolytic activity in synovial fluid of patients with osteoarthritis and inflammatory arthropathies....
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Báo cáo y học: " A computational approach for genome-wide mapping of splicing factor binding site" pdf

... PTB:polypyrimidine tract-binding protein; SF: splicing factor;SFBS: splicing factor binding site; SR: serine-arginine-rich;SS: sum of scores; TPR: true positive rate; TSI: tissue specifi-city index; ... shown to play a critical role in regulating tissue-specific (mainly brain)exons, including its own mRNA [53]. In the core network,PTB is found in the first layer, but it has in- edges coming fromother ... splicingregulatory machinery, not only by protein-protein interac-tions in the spliceosome but also via protein-RNA interac-tions at the post-transcription/translation levels.Materials and methodsData...
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Báo cáo y học: " A Practical Approach to Managing Patients with HCV Infection"

... Symptoms in HCV infection do not appear to be linked to disease activity; neither do appear to be correlated with serum aminotransferase levels or liver histological findings [15,16]. In ... A phase II study indicated a lower rate of anemia induced by viramidine than ribavirin. However, its efficacy remains to be determined by ongoing clinical trials. Several types of HCV-specific ... Natural History of HCV Infection The natural history of HV infection was thoroughly reviewed by Drs. Chen and Morgan in this issue. Knowing the natural history of HCV infection is important in the...
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Báo cáo y học: "A Practical Approach to Management of Chronic Hepatitis B"

... hepatic inflammation carry a significantly higher risk of disease progression. Histological staging of HBV disease is clinically very valuable in assessing degree of fibrosis and predicting disease ... liver biopsy may not be necessary. As it will be discussed below, histological assessment is very valuable in determining HBV treatment in patients with persistently normal transaminases. ALT ... challenge remains in optimizing HBV therapy. First, further understanding HBV dynamics and correlation of the level of HBV replication with liver injury will be invaluable for us to define an evidence-based...
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Báo cáo y học: "An innovative method to evaluate the suture compliance in sealing the surgical wound lip"

... surgeries NOVARFIL: polybutester polymer monofilament indefinitely / good Skin closure POLYURETHANE: polyurethane polymer monofilament indefinitely / very good Skin closure, general, cardiovas-cular, ... threads, like polypropylene and polyamide, in relation to wound sealing and scar formation. Key words: suture threads, polyurethane, polypropylene, polyamide, wound-lip-sealing properties INTRODUCTION ... copolymer coated by polyglactin 370, 910 and Ca++ stearate braided 65% at 14 days 50-70 days good not for tissue continuously stressed MONOCRYL: glycolide and epsilopn caprolacton copolymer...
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Báo cáo khoa học: "A Computational Approach to Zero-pronouns in Spanish" doc

... appear,linguistically, in the text (they refer to items in the external world rather than things referred to in the text). Finally, the third category is that ofpronouns that will be resolved by our computational ... computational processing, semantic anddomain information is computationallyinefficient when compared to other kinds ofknowledge. Consequently, current anaphoraresolution methods rely mainly on restrictionsand ... therefore obtaininformation about its gender from the object,guapa (beautiful in its feminine form) whichautomatically assigns it to the feminine genderso the omitted pronoun would have to be...
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