... hours under influence of CSE.Together, the results of their study and ours match the outcome of fibrosis in the airways and excess ECMdestruction in the parenchyma as observed in emphy-sema.Lung ... to obtain more insight in the underlying mecha-nisms of this selective susceptibility, following ourhypothesis that the Smad pathway is involved. Because of the limited knowledge on gene modulation ... Groningen, University of Groningen, Hanzeplein 1, NL-9713 GZ Groningen, The Netherlands and 2Department of Pulmonology, University Medical Center Groningen, University of Groningen, Hanzeplein...