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Báo cáo y học: "A non-parametric approach for identifying differentially expressed genes in factorial microarray experiments" potx

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Báo cáo y học: "A non-parametric approach for identifying differentially expressed genes in factorial microarray experiments" potx

... analyze microarray time-series data in cell cycle [16] and in diabetes research [17] to look for genes displaying distinct time-course expression profiles. In microarray experiments using a factorial ... represented firstly by genes differentially expressed in the two cell lines, and secondly by genes regulated in response to vitamin D treatment in the hMSC-dlk1 cell line. In addition, note ... oligonucleotide array probe level data. Biostatistics, 2003, 4: 249-264. 25. Reiner A, Yekutieli D, Benjamini Y: Identifying differentially expressed genes using false discovery rate controlling procedures....
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Báo cáo y học: "A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data" pot

... Turpaz Y: Ploidy status and copynumber aberrations in primary glioblastomas defined by integratedanalysis of allelic ratios, signal ratios and loss of heterozygosity using500K SNP Mapping Arrays. ... alleliccomposition in nonpaired, primary tumor specimens by use ofaffymetrix single-nucleotide-polymorphism genotyping microarrays. AmJ Hum Genet 2007, 81:114-126.28. Yau C, Holmes CC: CNV discovery using ... providing the cell line data for HL-60 and HT-29. CY is fundedby a UK Medical Research Council Specialist Training Fellowship in Biomedical Informatics (Reference No. G0701810) and previously by...
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Báo cáo y học: "A new approach for the large-scale generation of mature dendritic cells from adherent PBMC using roller bottle technology" ppt

... set up for each experiment. The floating cells were harvested one day later and viable cellrecovery was determined by Trypan Blue staining with a hemocytometer followed by FACS staining for CD83 ... matured using any one of a number ofwell-defined defined cytokine cocktails. This resulted in alarge number of floating non-adherent mature DC thatcan be easily harvested and used for vaccines ... cocktail and stained for CD11c, CD13, CD14, CD83 and CD86 and analyzed by flow cytometry. In each case all the isolated floating cells were analyzed without gating and phenotype of DC compared...
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Báo cáo y học: "A systematic approach for the identification of novel, serologically reactive recombinant Varicella-Zoster Virus (VZV) antigens" ppsx

... anti-RGS-Hisantibody, H) Analysis of purified proteins by SDS-PAGE and Coomassiestaining, I) Screening for serologically reactive antigens in microarray format, J) Rearrangement of screened marker antigens in ... the suitability of the recombinant line assay for VZV serodiagnostics.ResultsSerum profiling experiments in microarray format24 VZV proteins could be expressed in small-scale in E. coli Rosetta ... repurification in large scale in order to apply these antigens onto aline assay (recomLine VZV).Evaluation of the identified VZV antigens by a line assayVZV IgM and IgG reactivities in clinically defined...
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Báo cáo y học: " A novel approach for prediction of tacrolimus blood concentration in liver transplantation patients in the intensive care unit through support vector regression" doc

... Apparently,these 2 input variables contained more information in a nonlin-ear way than the other 15 or 16 contained in a linear way.When a linear method (linear SVR or MLR) was examined withonly ... variables.BackgroundHospital information systems in intensive care medicine gener-ate large datasets on a daily basis. These rapidly increasingamounts of data make the task of extracting correct and rele-vant clinical ... of Statistical Learning Theory Berlin, Ger-many: Springer-Verlag; 1995. 30. Boser BE, Guyon IM, Vapnik VN: A training algorithm for optimalmargin classifiers. In Proceedings of the Fifth Annual...
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Báo cáo y học: "A comparative approach for the investigation of biological information processing: An examination of the structure and function of computer hard drives and DNA" doc

... centralized information storage and processing, expand-ing t he CHD/DHD analogy requires understanding and defining the additional infor-mation processing activities necessary in order to maintain a ... theprograms in situ, without crashing the machine. This can only be done by recognizingthe control structures involved in cellular information processing and understandingthe systems architecture ... Theflux information will be converted to electrical signals, which are interpreted by encod-ing/decoding algori thms as a logical one o r zero, creating the binary information. Theinformation...
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Báo cáo y học: " A computational approach for genome-wide mapping of splicing factor binding site" pdf

... applying Single Scores (S) only.Click here for fileAdditional data file 3Experimentally defined SFBSs used for training and testingExperimentally defined SFBSs used for training and testing.Click ... were mainly enriched in SFBSs in the5' introns, but not in the 3' introns. Correspondingly, the ADexons were enriched with SFBSs in the 3' introns but not in the 5' introns. ... [10], bindthe pre-mRNA in multimeric units. In several cases the bind-ing sites are found in relatively long RNA stretches, such asthe polypyrimidine tract that harbors binding sites for PTBand...
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Báo cáo y học:

Báo cáo y học: " A computational model for functional mapping of genes that regulate intra-cellular circadian rhythms" pps

... pharmacotherapy by maximizing the potencyand minimizing the toxicity of the drug [7], whereas drugadministration at an inappropriate body time can inducemore severe side effects [8]. In practice, body-time-dependent ... for circadian rhythms. In a mapping study of196 F2 hybrid mice, Shimomura et al. [24] detected 14interacting QTL that contribute to the variation of rhyth-mic behavior in mice by analyzing ... abundance (y) in a rhythmic system, expressed as limit cycle con-tour, annotated with the time points within the 24.6 h circadian cycle, for three assumed QTL genotypes using given rhythmic parameter...
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Báo cáo y học: " A statistical model for the identification of genes governing the incidence of cancer with age" pptx

... proliferation. This model is defined by twokey parameters, carrying capacity (K) and intrinsic growthrate (r). Thus, by estimating genotype-specific differences in these two parameters, the genetic ... Financial Engineering, Princeton University, Princeton, NJ 08544, USAEmail: Kiranmoy Das - Kiranmoy@stat.ufl.edu; Rongling Wu* - rwu@stat.ufl.edu* Corresponding author AbstractThe cancer incidence ... progression. We incorporate the mathematical equations of age-specific cancerincidence into a framework for functional mapping aimed at identifying quantitative trait loci (QTLs) for dynamic changes...
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Báo cáo y học: "A genomic approach to investigate developmental cell death in woody tissues of Populus trees" pot

... model system for stud-ying early vascular development and primary growth, it can-not be easily used for studying secondary growth of the stem.Xylem fibers are formed in Arabidopsis only after ... been analyzed in detail in an in vitro system of Zinnia elegans, in which mesophyll cells ofZinnia transdifferentiate into xylem vessels commonly calledas tracheary elements in a semi-synchronized ... proteinPOPLAR.5071 expressed proteinPOPLAR.155 S-adenosylmethionine synthetasePOPLAR.58 polyubiquitin 4POPLAR.862 arabinogalactan-protein AGP13POPLAR.3587 glycosyl hydrolase family 17 proteinPOPLAR.166...
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