Báo cáo y học: "A non-random walk through the genome" pdf
Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot
... C-terminally to the CBM that playspecific roles in activation of the receptor by these twocytokines. The ligand independent activation of the D5-GCSFRchimera occurs in both the absence and the presence ... antibody 10B2 (LIFR) followed byphycoerythrin-conjugated secondary antibody (black histograms). As a negative control, mock-transfected cells were treated in the same way (grayhistograms). The ... a system that allows the study of gp130mutants together with the LIFR in COS7 cells despite the presence of low amounts of endogenous wild-type receptors.To achieve this, the cytoplasmic tyrosine...
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Báo cáo Y học: Activation of transcription through the ligand-binding pocket of the orphan nuclear receptor ultraspiracle docx
... binding of methyl epoxyfar-nesoate, then the change in the local environment of the twoadded tryptophan residues on a-helix 12 may change theirfluorescence in a way that yields a markedly different ... methyl epoxyfarnesoic acid (yellow carbon backbone and blue terminal carboxylate oxygens) lainmanually in the dUSP ligand-binding pocket with the carboxy and distal (epoxy) ends, respectively, ... probes confirmed the specificity of binding. The similar formation of the homodimer form by the wild-type USP and mutant USP, along with the similar binding to DNA of the wild-type USP and mutant...
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Báo cáo y học: "A case study evaluating the use of clozapine in depression with psychotic feature" docx
... limited. The only evidence specific for the question is limited tolow-level evidence with only case study/series evidence. The higher quality evidence is limited by being non-spe-cific, especially ... ideation. There was nohistory of alcohol/substance misuse or any medical prob-lems. She had been receiving ECT treatment twice weeklyin the community for the 4 months preceding the admis-sion. The ... in the treatment of psychotic refractory depression. Br J Psychiatry1993, 163:822-4.9. Hrdlicka M: Combination of clozapine and maprotiline inrefractory psychotic depression. Eur Psychiatry...
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Báo cáo y học: "Transfers to psychiatry through the consultation-liaison psychiatry service: 11 years of experience" pdf
... than on the treatment of theirsomatic illness, their transfer to psychiatry often appears the only way to deal with them. In addition, the negativefeelings of the doctors, the staff, and the rest ... rehabilitation psychiatric services butalso by pressure from physicians and, of course, by the understanding on the psychiatrist's side of the stress the physicians and the staff involved ... studyworked at the above department during the study period). The files of the patients transferred to the psychiatric unitby the consultation-liaison service between 1 March 1989(opening of the...
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Báo cáo y học: "A short review on the aetiology and pathophysiology of alcoholism" ppt
... Hesselbrock V, Meyer RE, Dolin-sky ZS, Rounsaville B: Types of alcoholics. I: evidence for anempirically derived typology based on indicators of vulnera-bility and severity. Arch Gen Psychiatry 1992, ... individuals with a familyvulnerability to alcoholism. Am J Psychiatry 2004,161(10):1776-1782.27. Yudofsky SC, Hales RH: The American Psychiatric Publishingtextbook of neuropsychiatry and clinical ... serotoninergic dysfunction [29].A similar effect appears through modification of the func-tional activity of the proteins that are already inside the neuron or through the influence of alcohol on their...
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Báo cáo y học: "γ A novel mechanism for the regulation of IFN-γ inducible protein-10 expression in rheumatoid arthritis" ppsx
... primaryantibody, and biotinylated polyclonal goat anti-IP-10(0.1 µg/ml) served as the secondary antibody. The sensi-tivity limit for the IP-10 enzyme-linked immunosorbentassay was approximately ... regulated not only by inflammatorycytokines but also by the physical interaction of activatedleukocytes with fibroblast-like synoviocytes, and that IP-10 maycontribute to the recruitment of ... USA) density gradient, after which theywere separated from erythrocytes by lysing the erythro-cytes in a solution of 0.15 mol/l NH4Cl, 0.01 mol/lNaHCO3, and 0.01 mol/l tetra EDTA. The recoveredPMNs...
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Báo cáo y học: "A comparative study of the inhibitory effects of interleukin-1 receptor antagonist following administration as a recombinant protein or by gene transfer." pps
... lacking glycosylation [26]. In the first part of the present study similar end-point levels oftransgenic and recombinant IL-1Ra were necessary toinhibit fully the response of synoviocytes to ... methionine, the native molecule may have greater bio-logic potency than the recombinant one. The present study was designed to compare quantitatively the relative effectiveness of these two avenues ... cultures receiving the low dose of protein or cells, the grey bars the medium dose, and the black bars the high dose. The inset above reflects the corresponding IL-1Ra concentrations in the conditioned...
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Báo cáo y học: " A promoter haplotype of the interleukin-18 gene is associated with juvenile idiopathic arthritis in the Japanese population" pps
... polyarthritis and systemic subgroups, the frequency of haplotype S01 did not differ statistically from thatof healthy controls. The frequency of haplotype S01 was alsosignificantly higher in the patients ... participated in the design and coordination of the study, and recruited a subset of the patients. ST conceived the study together with Y Kawano and participated in the designof the study. HI and HTI ... Foster City, CA,USA). In the present study, we typed these 10 polymorphicsites for each individual because they were sufficient to esti-mate the haplotype and a diplotype configuration. As listed...
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Báo cáo y học: "A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis" doc
... when interpreting the data. The primary limitation is the heterogeneity among studies interms of the data sources, populations examined, and studydesigns. The diversity of study methodologies ... between rheumatology and oncologydepartments. Uncertainty regarding the size of the RA popula-tion evaluated may account for their very high reported relativerisk of 7.4 for Hodgkin lymphoma. Sources ... mis-classification of the inclusion of patients into the RA popula-tions, and there may have been uncertainty surrounding the diagnostic accuracy of the malignancies. Several of the stud-ies were...
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Báo cáo y học: "A meta-analysis of the efficacy of fibromyalgia treatment according to level of care" pptx
... although both of these are biased by the heteroge-neity of the studies. Other variables that also improve out-come, which are not biased by the heterogeneity of the studies, are younger patient ... summarised the results of the most fre-quently used in the studies revised: global function, pain andFIQ. The quality of the studies was rather low with only one-third of them rating 5+ on the Oxford ... bothfactors were biased by the heterogeneity of the studies. Othervariables that also improved outcome and were not biased by the heterogeneity of the studies, were younger age of the patients and shorter...
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