Báo cáo y học: "Why genomics is more than genomes" pot
Báo cáo y học: "Why genomics is more than genomes" pot
... in other systems. Yet TinaHenkin (Ohio State University, Columbus, USA) has recentlyproposed that many Gram-positive bacteria regulate genesfor amino-acid biosynthesis and tRNA synthetases ... nearly 200 at the time of writing andthey offer a powerful route to understanding aspects of amicroorganism’s biology. Yet, as shown at the 2004 meeting,there are always new aspects of biology ... Genome Biology 2004, 5:357commentreviewsreportsdeposited researchinteractionsinformationrefereed researchMeeting reportWhy genomics is more than genomesJeffrey G LawrenceAddress:...
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Báo cáo y học: "Why genes persist in organelle genomes" doc
... support the validity of the hydrophobicityhypothesis [5,16-26,28,29]. The flaws of each hypothesisOn the surface, the hydrophobicity hypothesis does notappear to adequately explain the retention ... Genome Biology 2005, Volume 6, Issue 5, Article 110 Daley and Whelan 110.3Genome Biology 2005, 6:110Box 1An explanation of terms The hydrophobicity hypothesis. This hypothesis ini-tially proposed ... reviewcontaining more details of this process is available [44]. The second apparent ‘flaw’ in the hydrophobicity hypothesis is that both mitochondria and chloroplast import manyhydrophobic proteins. Why...
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Báo cáo y học: "Identifying repeat domains in large genomes" pot
... protein domains is a well-establishedresearch area, the study of repeat domains is still in itsinfancy. Indeed, RepeatGluer [17] is the only existing algo-rithm for repeat domain analysis. While ... a repeat library typically contains severalhundred to several thousand sequences, and the annotationof repeats is typically incomplete, the analysis of a repeatdomain graph is a nontrivial ... identify repeat domains by ana-lyzing repeat family libraries that are obtained via othermeans.The main challenge in the analysis of repeat domains is thatrepeat family consensus sequences typically...
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Báo cáo y học: "Why are some children with early onset of asthma getting better over the years" -aneuploid-prostate-cancer-cells-after-tmz-tmz-bioshuttle-treatment.html#post143974
... quality program for asthma diag-nosis is nowadays shared, but was more lax 15 years ago than today, which introduces a possible bias since many of the NA cases were early diagnosed. Yet, there ... needing ther-apy for the rest of their lives, but asthma remission also does exist (12). The more severe the asthma is in childhood the more likely it is that the disease will persist in adulthood ... to this cohort (19). Interestingly, the exposition for pet animals tended to be higher in the NA cases, which may support the hygiene hypothesis, but may also be due to higher sensitivity in...
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Báo cáo y học: "Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and translational processes"
... (Affymetrix). DNA microarray analysis Data analyses were performed using the GeneChip Expression Analysis Software (version 3.2, Affymetrix). First, single array analysis was performed [11] to ... concentrations of ethanol. Gene expression profiling using microarray technology allows the expression analysis of thousands of genes simultaneously [6-8]. This method is more informative than nonparallel ... One-Cycle cDNA Synthesis Kit (Affymetrix). Fifteen micrograms of labeled and fragmented cRNA were subsequently hybridized to a Human Genome U133 plus 2.0 microarray (Affymetrix). After the hybridization,...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
... patternsyielded, in polyacrylamide gel at pH 8.6, by the new as1-Casphenotype, subsequently shown to be a heterozygous M/F(M being the new variant), in comparison with tworeference phenotypes ... [18].Enzymatic hydrolysesTrypsin (Boehringer Mannheim) hydrolysis was carried outin 0.4% NH4HCO3,pH8.5,at37°C, for 4 h, in asubstrate/enzyme ratio of 5 0 : 1 (w/w). Dephosphorylationwith ... intron 5 is also shorter than the cattle one. This could be expected,given the phylogenetic proximity between sheep and goats.Genotyping of theMalleleThe genotyping procedure designed consists...
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Báo cáo Y học: Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration docx
... mitochondria is mediated by the cytoplasmic HSP70.ACKNOWLEDGEMENTSWe thank Dr. K. Nagata (Kyoto University) for his helpful commentson the manuscript. We thank Dr. D. J. Naylor (The University ofAdelaide, ... proinflammatory cytokine, tumournecrosis factor a, and with various psychosocial measures[15]. In the mammalian cytoplasm, HSP60 may playimportant roles including chaperone activity, immunophi-lin, ... mizoribine is cytoplasmic HSP60.These results suggest that HSP60 is not quickly importedinto the mitochondria after being synthesized in thecytoplasm. Recently, it has been shown that cytoplasmicHSP60...
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Báo cáo Y học: Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge pptx
... peptidewith four disulfide bridges (2256.74 MH+), with only a0.8-Da difference. Computer analysis indicated that thispeptide is a new member of the hepcidin family, basshepcidin (SwissProt number ... that wasanalyzed in these same fish and found not to be induced inany tissue [8].DISCUSSIONWe report here the discovery of a novel AMP, basshepcidin, isolated from the gills of hybrid striped ... characteristics with any of the cysteine-rich insect AMPs, insect defensins, or Drosophila drosomy-cin [21]. The different cysteine positions and disulfide arrayspredict completely different...
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Báo cáo Y học: Arginine 121 is a crucial residue for the specific cytotoxic activity of the ribotoxin a-sarcin potx
... Myr2GroPGro,dimyristoylglycerophosphoglycerol; Nbd-Myr2GroP Etn, [N-(7-nitro-2-1,3-benzoxadiazol-4-yl)-dimyristoylglycerophosphoethanolamine;rhodamine-GroP Etn, N-(lissamine rhodamine B sulfonyl)-diacylglycerophosphoethanolamine; ... family display a high degree ofsequence similarity although they are secreted by a varietyof different moulds [9–11], i.e. restrictocin and mitogillin,two other members of this family, display ... wasmeasured by fluorescence energy transfer assays [47] asdescribed [45,48]. A decrease in the donor-to-acceptor,[N-(7-nitro-2-1,3-benzoxadiazol-4-yl)-dimyristoylglycero-phosphoethanolamine (Nbd-Myr2GroP...
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Báo cáo y học: "How possible is the development of an operational psychometric method to assess the presence of the 5-HTTLPR s allele? Equivocal preliminary findings" pdf
... antidepressants more likely [15-17,28-31].Understanding the underlying biological and personalityfactors profoundly shapes and reorganises how we viewpsychiatric disorders today and how they will be ... polymorphis ms only mildly contrib uteto such ph enotypical alterations, they may be taken intoaccount when selecting a pharmacological agent. A scaleclosely related to a given polymorphism ... Psychological Testing New York, USA: Macmillan PublishingCompany, 6 1988.26. Gonda X, Fountoulakis KN, Rihmer Z, Lazary J, Laszik A, Akiskal KK,Akiskal HS, Bagdy G: Towards a genetically validated...
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