... draftedthe manuscript and participated in data acquisition. VP partic-ipated in data acquisition, provided technical assistance andassisted in analysis and interpretation of data. TT, HJ and IAparticipated ... Kubo M, Kiyohara Y, Kato I, Iwamoto H, Nakayama K, Hirakata H,Fujishima M: Effect of hyperinsulinemia on renal function in a general Japanese population: the Hisayama study. Kidney Int1999, ... hyperuricaemia [20,45].Apart from a direct pathogenic association of UA with renal dysfunction, alternative explanations may also apply. To start with, UA may just be 'marking' patients...