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Báo cáo y học: "The determinants of gene order conservation in yeasts" pdf

Báo cáo Y học: The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli doc

Báo cáo Y học: The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli doc

... Together, these data indicatethat the helix breaker in cleavable signal sequences prevents recognition by SRP and is thereby, together with the hydrophobicity of the signal sequence, a determinant ... H.C. & Bernstein, H.D. (2001) The targeting pathway of Escherichia coli presecretory and integral membrane proteins isspecified by the hydrophobicity of the targeting signal. Proc. Natl.Acad. ... overloading of the SRP pathway. The re-routing of (G-10L)prePhoE to the Sec translocon via the SRPinstead of the SecB pathway could be explained by the increased hydrophobicity of the hydrophobic core...
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Báo cáo y học: "The importance of measuring psychosocial functioning in schizophrenia" pps

... Brissos et al.: The importance of measuring psychosocial functioning in schizophrenia. Annals of General Psychiatry2011 10:18.Brissos et al. Annals of General Psychiatry 2011, 10:18http://www.annals-general-psychiatry.com/content/10/1/18Page ... and terminol-ogy and considers the relationship between soci al func-tioning, psychopathology and cognition. Psychosocial functioning in schizophreniaDeficits in psychosocial functioning are ... improvements in social inte-gration, professional skills, and the quality of interpersonal relationships following intervention [2].Increasingly, symptom remission and ultimately recoveryare advocated...
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Báo cáo y học: "The value of sensitive imaging modalities in rheumatoid arthritis pdf

... years have witnessed the emergence of a newparadigm in the treatment strategy for RA, involving earlyCommentaryThe value of sensitive imaging modalities in rheumatoid arthritis Peter C TaylorThe ... joints permit an increasingly refinedanalysis of anatomic detail. However, further research using these sensitive imaging technologies isrequired to delineate pathophysiological correlates of ... RA = rheumatoid arthritis; US = ultrasonography. Arthritis Research & Therapy Vol 5 No 5 TaylorIntroductionEvaluation of disease activity and structural damage tojoints in rheumatoid arthritis...
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Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc

... 2Research articleThe role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells Oliver Frey1, Peter ... With this in mind, itcould be interesting to investigate whether the accumu-lated T reg cells in patients with arthritis function properly in vivo and whether these patients could really benefit ... correct, then they could explainwhy the transfer of T reg cells after arthritis induction is noteffective. On the one hand, transfer of T reg cells 24 hours after intra-articular antigen...
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Báo cáo y học: "The determinants of change in tibial plateau bone area in osteoarthritic knees: a cohort study" doc

... men and women in the change in lateral tibial plateau bone area. Table 2Annual change and rate in tibial plateau bone area Crude analysis Adjusted analysisAnnual change Total P Men Women P a Men ... Principal outcome meas-ures in analyses were annual change and annual percentage change of tibial plateau bone area. Change in this area wasobtained by subtracting the bone area at baseline ... narrowing, and baseline tibial plateau bone area. Table 3Factors affecting annual percentage change in tibial plateau bone area Tibial plateau area factors a Univariate analysis Regression coefficient...
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Báo cáo y học: "The determinants of susceptibility/resistance to adjuvant arthritis in rats" ppt

... cells to undergo a Th1 to T-helper type 2 shift and increase thesecretion of anti-inflammatory cytokines IL-10 and IL-4, whiledecreasing the secretion of proinflammatory cytokines TNFαand IL-1 ... most of the available information regarding thetemporal cytokine profiles in arthritic LEW rats pertained to antigen nonspecific ex vivo cytokine secretion or to cytokinemRNA levels [38,39]. In ... and Wistar Albino Glaxorats) [40-42].Two aspects of cytokine function are of significance whenexamining the susceptibility/resistance to AA. First, the pro-inflammatory cytokines (for example,...
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Báo cáo y học: "The importance of localizing pulmonary veins in atrial septal defect closure" ppsx

... AccessThe importance of localizing pulmonary veins in atrial septal defect closure!Ahmad Ali Amirghofran1, Ashkan Karimi2*, Gholam Hossein Ajami3and Alireza Rasekhi4AbstractAn 8-year-old ... discovery of three additional anomalies, namely Interrupted Inferior Vena Cava (IIVC),Scimitar syndrome, and systemic arterial supply of the lung. Postoperatively these finding were confirmed by CTangiography. ... Cardiopulmonarybypass was established by aorto-bicaval cannulatio n, andthe ASD was approached through right atriotomy. Intrao-peratively there was no trace of the right pulmonary veins orifices...
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Báo cáo y học: "The role of toll-like receptors in acute and chronic lung inflammation" pdf

... duringinfluenza infection suggests that it may play an impor-tant role in immune signaling [101]. Deletion of TLR3leads to downregulation of inflammatory cyt okine and chemokine production and ... confer hypersusceptibility,increased lung bacterial load, and deficient neutrophilrecruitment [114,117-123]. Interestingly, MyD88 mayplay an essential role only during the early phase of infec-tion ... T LRsignaling. In addition to TLRs, a variety of other PRRs includingthe cytoplasmic NLRs and RLRs play important roles in the induction of lung inflammation. For example, the cyto-plasmic...
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Báo cáo y học: " The effectiveness of problem solving therapy in deprived South African communities: results from a pilot study" pps

... this article as: van’t Hof et al.: The effectiveness of problem solving therapy in deprived South African communities: results from a pilot study. BMC Psychiatry 2011 11:156.van’t Hof et al. ... translated into English,Xhosa and Afrikaans, the three official languages spoken in South Africa’s Western Cape Province. The accuracy of the translations was checked by back-translating the English ... F, Lyrene B: The efficacy of Self-Examination Therapy and Cognitive Bilbiotherapy in the treatment of mild to moderatedepression. Psychotherapy Research 1995, 5:131-140.44. Bowman D, Scogin...
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Báo cáo y học: "The role of pleiotrophin and β-catenin in fetal lung development" doc

... Wnt signaling in adult lung causes lung cancer, fibrosis, and inflammation [109]. Hyperactivation of β-catenin, caused by mutations of β-catenin, APC, and axin in lung epithelium induces lung tumors ... W, Yamin M, Noda M, et al.: Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein ... Perez-Pinera P, Deuel TF: Fyn is a downstream target of the pleiotrophin/ receptor protein tyrosine phosphatase beta/zeta-signaling pathway: regulation of tyrosine phosphorylation of Fyn by pleiotrophin. ...
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Báo cáo y học: "α The role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritis" pot

... model.Editorial The role of anti-αα-actinin antibodies in the pathogenesis and monitoring of lupus nephritisPierre Youinou1 and Chaim Putterman2,31Laboratory of Immunology, Brest University Medical ... strongly to α-actinin [12,13]. Moreover, anincrease in serum anti-α-actinin antibodies in lupus patientswas associated with a 2.5-fold increase in the prevalence of LN [14]. Finally, levels of anti-α-actinin ... followed by Manson and colleagues [1] were being treated, and anti-α-actinin antibodytiters may decrease with therapy. Finally, perhaps anti-dsDNA antibodies not measured by the assay used in this...
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Báo cáo y học: " The mode of lymphoblastoid cell death in response to gas phase cigarette smoke is dose-dependent" potx

... Whenexposed to high toxicity, the majority of the cell popula-GPS treatment results in the cytoplasmic release of cyto-chrome CFigure 4GPS treatment results in the cytoplasmic release of cytochrome ... analysis of Annexin V/PI-stained cells To determine the mode of cell death upon GPS treatment,cells were stained with AnnexinV/PI and analysed by flowcytometry, 2 h post-exposure. As seen in ... in turn diluted in the existingair volume in the airways so that the resulting toxicity is not instantly detrimental for the epithelium, or the tissuessurrounding it. Instead, chronic smoking...
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Báo cáo y học: " The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during " doc

... timepoint. This could have resulted in decreased levels of phagocytosis due to the deficiency in the binding and opsonisation of the pneumococcusdue to the lack of SP -D, but also could be due ... the appearance of pneumococci in the blood and in limitingtheir numbers in the bloodstream.SP -D binds and agglutinates S. pneumoniae in the presence of calcium and is thought to enhance mucociliary and phagocytic ... findings, we hypothesise that SP -D hasan important role to play in the innate immune defence of the upper and lower respiratory tract against pneumo-coccal infection in vivo, by promoting the...
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Báo cáo y học: "The determinants of gene order conservation in yeasts" pdf

... of inversionsProportion of gene pairs still as neighboursDifferences in intergene distanceFigure 2Differences in intergene distance. Intergene distances of gene pairs currently in synteny ... predictors in our study as controls. In summary,this analysis confirms the relevance of several aspects of gene expression control and genetic linkage as predictors of syn-teny conservation in yeast. ... are unique in having no promoter sequence in the intergene spacer. Thismight in part explain why in many cases a further regularityappears, namely that gene pairs currently closely linked (thatis,...
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Báo cáo y học: "The rarity of gene shuffling in conserved genes" pptx

... properly cited.The rarity of gene shuffling in conserved genes<p>The incidence of gene shuffling is estimated in conserved genes in 10 organisms from the three domains of life. Successful gene ... example,duplication of domains within a gene. In such a gene shuffling event, the parental genes may be either destroyed or pre-served [6]. Gene shuffling is clearly the most potent of thethree causes of functional ... foranciently diverged species pairs. For example, only 82Identifying gene shufflingFigure 1Identifying gene shuffling. (a) Gene shuffling and how it changes gene structure. The three scenarios of...
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