Báo cáo y học: "My 2,000 best films: parallel phenotyping of Dictyostelium development" doc

... Biology 2007, 8:220MinireviewMy 2,000 best films: parallel phenotyping of Dictyostelium developmentGareth Bloomfield*†and Robert R Kay*Addresses: *MRC Laboratory of Molecular Biology, Hills ... delineation of cell-cycle genesin yeast [2] and the identification of genes underlyingdevelopment in Drosophila [3]. Such screens always requireingenuity of inception but, especially in metazoa, they ... fordevelopmental mutants of the social amoeba Dictyostelium discoideum, based on parallel time-lapse filming, whichmoves in this direction.The particularities of Dictyostelium Dictyostelium brings...

Báo cáo y học: "Genetic studies in osteoporosis - the end of the beginning" docx

... 605497LEPRE1 Prolyl 3-hydroxylase Osteogenesis imperfecta type VIII 610339PLOD2 Lysyl hydroxylase-2 Bruck syndrome (osteogenesis imperfecta with 601865joint contractures) type 2CA2 carbonic anhydrase ... ratio of fracture of 2.25 (the risk of fracture was increased by 2.25 in carriers of all five SNPs)and a likelihood of fracture of 0.75 in those who did not carrythe SNPs. The combination of carriage ... treated with the alkylating agent ethinyl-nitrosourea, causing point mutations in sperm DNA. Offspring of these mice carry these mutations. By screening thousands of offspring of mutagenized mice,...

Báo cáo y học: " The PIN-FORMED (PIN) protein family of auxin transporter" doc

... strictoChlorophyta(majority of green algae)Mesostigma, Chlorokybus cladeKlebsormidiophyceaeZygnematophyceaeColeochaetophyceaeCharophyceae - StonewortsMarchantiophyta - LiverwortsBryophyta - MossesAnthocerotophyta ... Rhodophyta (red algae): Cyanidioschyzon merolae.ChlorophytaStreptophytealgaeEmbryophyta - land plantsSeed plantsVascular plantsLand plantsStreptophytaRhodophyta - red algaeGlaucophytaArchaeplastida ... Arabidopsis thaliana; Alyr, Arabidopsis lyrata; Bradi, Brachypodium distachyon; Cpap, Carica papaya; Glyma, Glycine maxima; Mtru, Medicago truncatula; Osat, Oryza sativa; Ppat, Physcomitrella patens;...

Báo cáo y học: "Quake: quality-aware detection and correction of sequencing errors" docx

... small repeats. Assembly of the raw uncorrected reads was quite poor because of the very low quality suffixe s of many of the 124 bp reads.Thus, we compare assembly of quality trimmed reads(performed ... counts, many of whichare artifacts of sequencing errors. Instead of executingthis computation on a single large memory machine, weharnessed the power of many small memory machinesworking in parallel ... same regardless of quality.Furthermore, specifics of the Illumina technology causecer tain miscall s to be more likely than oth ers. For exam-ple, bases are called by analysis of fluorescent...

Báo cáo y học: " Transcriptional control in the prereplicative phase of T4 development" pot

... Methods 2009,47:1-5.22. Vassylyev DG, Sekine S, Laptenko O, Lee J, Vassylyeva MN, Borukhov S,Yokoyama S: Crystal structure of a bacterial RNA polymerase holoenzymeat 2.6 A resolution. Nature ... wt T4 DNA, each cytosine in thissequence is modified by the presence of a hydroxy-methylated, glucosylated moiety at cytosine position 5.This modification places a large, bulky group within ... stabi-lity of such transcripts once they are formed.As middle transcription begins, certain early RNAsdecay rapidly after their initial burst of transcription.This arises from the activity of the...

Báo cáo y học: " Exhaled nitric oxide and clinical phenotypes of childhood asthma" docx

... FENOmay define an asthma phenotype. They demon-stratedthattheirhighFENOphenotype (FENO 0.05>35ppb) was characterized by greatest airway reactivity, air-flow limitation, hyperinflation, ... for estimation of the number of likely clus-ters that was further prespecified in a k-means clusteranalysis)[22]. Finally, characteristics of clusters werecompared using analysis of variance ... Thirdly, therapeutic compliance (and inability touse the inhaler properly) in children may be difficult toobtain [33] that may further explain the presence of mild symptoms.Usefulness of FENO0.05measurementWe...

Báo cáo y học: "Cough and dyspnea during bronchoconstriction: comparison of different stimul" doc

... path-ways or the existence of primary and secondary coughafferent pathways [21]. Also, there is a suspicious that acomplex allergic reaction in the airway may be involved inthe development of ... sensitivity [22]. There is evidence of the involve-ment of airway vagal afferents, such as sensory C-fibers,and rapidly adapting receptors in the cough reflex, as wellas in other symptoms of respiratory ... 2 shows intensity of symptoms among stimuli.Cough induced by bradykinin was more intense. Bradyki-nin also led to more intense breathlessness detected byVAS scale, but not by Borg scale. The...

Báo cáo y học: "Programme costs in the economic evaluation of health interventions" docx

... every 80 squarekilometres of space. This implies that health centres maynot always run at 80% capacity, since more remote areasmay have a very low population density. Since costs of training of ... average cost of different ways of directly observing tuberculosis treatmentas a means of improving adherence. For the option of completely ambulatory short course chemotherapy withdaily supervision, ... averagesize of a province or district was calculated by dividing thetotal area of a country by the number of provinces or dis-Table 2: Mark-up of goods to account for the cost of transportCountry CIF/FOB...

Báo cáo y học: "Canada. §Research Unit on Biomedical Informatics of IMIM/UPF" doc

... patterns are likely to beovershadowed by the great variation of rates of divergenceacross the genome. Analysis of unfiltered data produces thesame patterns, of course, but most of the effect is ... evolu-tionary rates are significantly lower for coding evolutionaryrates. Finally, for those genes that overlap SDs and are sharedby the human and chimpanzee lineages, only synonymousdivergence ... thelower rates of divergence for genes overlapping SDs that weredetected in the overall analysis may be an artifact of the pre-liminary state of the annotation of chimpanzee SDs. At anyrate, we...

Báo cáo y học: "IA simple, fast, and accurate method of phylogenomic inference" docx

... sequences.Comparison of phylogeny-based and similarity-based phylotypingAlthough our phylogeny-based phylotyping is fully auto-mated, it still requires many more steps than, and is slowerthan, similarity based ... simulation study each query sequence was assigned aphylotype independently.Phylotyping simulation studyTo assess the performance of the phylotyping methods, a sim-ulation study was carried ... compare quantitatively the performance of the phylogenybased and the similarity based phylotyping, we carried out asimulation study. We determined the sensitivity and specifi-city of the taxonomic...

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