Báo cáo y học: "Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains" potx
Báo cáo y học: "Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains" potx
... duplicatedpathogenicity island, of which there is only one copy in U112[26]. The duplication of the Francisella pathogenicity islandmay provide a higher level of expression of the virulencegenes ... nonpathogenic to humans provides a coarse chronology of the evolutionary events that took place during the emergence of the formerA reduced set of genes was inactivated in the genome of the ... involved in the emergence of Fran-cisella human pathogenic strains, we compared the genomes for human pathogenic strains with the genome of a strain thatis not pathogenic to humans, namely Francisella...
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Báo cáo y học: "κ Increased AP-1 and NF-κB activation and recruitment with the β combination of the proinflammatory cytokines IL-1β, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocyte" ppt
... inflammatory diseasecharacterized by the infiltration of the synovial membrane with monocytes/T cells, by the proliferation of synovial liningcells and by the production of proinflammatory cytokines,which ... Conversely, in RA synoviocytes, we founda higher effect of the combination of IL-17 with IL-1β than with TNF-α. The strongest effect was observed for the combination of the three proinflammatory cytokines.Even ... regulatory effect,leading to the amplification of the action of other cytokines.Contribution of the T-cell-derived cytokine IL-17 to IL-1ββand TNF ααTF activation in RA synoviocytesT cells...
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Tài liệu Báo cáo Y học: Granule-bound starch synthase I A major enzyme involved in the biogenesis of B-crystallites in starch granules ppt
... followed the kinetics of amylose synthesis overa 5-day period of nitrogen starvation and measured the amounts of starch, amylose, the kmax of the starchfractions, the degree of crystallinity and the ... course of storage starch synthesis show that amylopectin and amylosesynthesis are partly disconnected and that amylose synthesispersists when the rate of polysaccharide and amylopectinsynthesis ... issynthesized in vivo when the rate of amylopectin synthesisbecomes minimal. At these moments the rates of amylopec-tin synthesis are only 5% of their maximal values. In fact thislow rate of...
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Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx
... T., Yamazaki, K., Kyogoku, Y. &Kobayashi, Y. (1998) Solution structure of thermostable cyto-chrome c-552 from Hydrogenobacter thermophilus determined by1H-NMR spectroscopy. Biochemistry ... aheme covalently attached to the polypeptide chain via twothioether bonds, formed from the vinyl groups of the hemeand the two cysteine residues in the consensus Cys-X-X-Cys-His motif [1–4]. ... and Phe34 to Tyr/Glu43 to Tyr (F3 4Y/ E4 3Y) ] in the three regions of PA c-551 each individuallyenhanced the overall protein stability [8]. These studies,together with structure analysis, provided...
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Báo cáo y học: "Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity" pps
... of spreading.In a key study [42] they showed that immunization of rabbits with the peptide PPPGMRPP, a repeated sequence within the carboxyl terminus of Sm B/B', led to a spreading of the ... supports both of thesepredictions. At the same time the model explains why, para-doxically, some type of T cell-B cell contact is required in the development of autoimmunity. Finally, the model ... the Sm particle.This view of the battle between the virus and the immune sys-tem is further amplified by the results of the analysis of MHC IIT cell epitopes using the ProPred server shown in...
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Báo cáo y học: "THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis" pps
... delayed the onset of arthritis as well as significantly reducing the clinical diseaseactivity score during the course of the experiment compared with CIA mice (Figure 1). From day 28 on, the ... inflammatory cytokines are thought to play a critical role in the pathogenesis of RA, we monitored the production of the proinfammatory cytokines TNF-α, IL-1β, and INF-γ as well asanti-inflammatory IL-4 ... examined by real-timeRT-PCR analysis. As expected, expression of each of thesecytokines was significantly increased with CIA (p < 0.001);treatment with THR0921 reduced cytokine levels nearly tocontrol...
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Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer''''s patches in an orally tolerized, collagen-induced arthritis mouse model" ppt
... approved by the Animal ResearchEthics Committee at the Catholic University of Korea.Preparation of type II collagenBovine CII was kindly provided by Professor Andrew Kang of the University of Tennessee. ... erythema limited to the foot or ankle, 2 =slight edema and erythema from the ankle to the tarsal bone,3 = moderate edema and erythema from the ankle to the tarsalbone, and 4 = edema and erythema ... activity in the smallintestine and the epididymis of mice. Arch Biochem Biophys1980, 203:343-351.33. Malina HZ, Martin XD: Indoleamine 2,3-dioxygenase: antioxidantenzyme in the human eye. Graefes...
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Báo cáo y học: " High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease." docx
... perspective on the dynamics of thesemolecules inside the cell and the diversity of activities thatthese molecules display once they are outside.Competing interests The authors declare that they have ... cells and amplify their activity because of theirphysical association (Figure 1).In its stimulation of the immune system, HMGB1 may differfrom conventional cytokines in another important aspect,kinetics ... Wahren-Herlenius M,Nyberg F: Translocation of the novel cytokine HMGB1 to the cytoplasm and extracellular space coincides with the peak of clinical activity in experimentally UV-induced lesions of cuta-neous...
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Báo cáo y học: "Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis" ppsx
... indicated by a spot, with the intensity of the spot representing the proportion of significantly differentially expressed transcripts for each one of the transcriptional modules. The color of the spot ... (HMFN0839)* 1-Acylglycerol-3-phosphate O-acyltransferase 9 [GenBank:NM_032717.3]34 MTHFD2 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase[GenBank:NM_006636.3]35 ... analyzed using the novel data with 100% accuracy as before, despite the change of microarray platform. (b) The performance of the 37 predictor genes was then further evaluated in a secondary independent...
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Báo cáo y học: " Protein kinase A-dependent Neuronal Nitric Oxide Synthase Activation Mediates the Enhancement of Baroreflex Response by Adrenomedullin in the Nucleus Tractus Solitarii of Rats" pps
... microinjection of the test agent into NTS. The BRR response was represented by the ratio of the peak magnitude of reflex bradycardia to the peak magni-tude of phenylephrine-induced pressor response. The averaged ... neuron. The enzyme activity of nNOS has been demonstrated tobe intimately associated with the state of phosphorylationat the amino acid residues Ser847 and Ser1416 [19]. Forinstance, phosphorylation ... The averaged value of BRR response obtained from threeinjections of phenylephrine prior to microinjection of the test agent served as the baseline control.HistologyAt the end of the p hysiological...
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