Báo cáo y học: "New perspectives on an old disease: proteomics in cancer research" pdf
Báo cáo y học: "New perspectives on an old disease: proteomics in cancer research" pdf
... MALDI-MS.Charting and quantifying changes in proteinphosphorylationCell signaling is often mediated by post-translationalmodifications that modify protein conformation, localiza-tion, activity and ... the intact protein analysis system (IPAS). Thiscombines protein labeling with Cy dyes, three-dimensionalprotein separation based on charge, hydrophobicity andmolecular mass, and protein identification ... thebloodstream. Using a hydrazide-based chemistry toselectively enrich for N-linked glycopeptides by affinitypurification, a 20-fold reduction in sample complexity wasachieved. Many of the glycosylated...
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Báo cáo y học: ":New tricks for an old-favorite model" pps
... an evolutionarily conserved function of sirtuins in regulation of replicative aging by maintenance of intact telomeric chromatin.Systems and synthetic biologyWhole-genome duplication during ... talk on yeast Sir2, which removes lysine 16 from histone H4, promoting chromatin silencing. Old cells have decreased levels of Sir2 protein and of histone H4 lysine 56 acetylation, and H4 lysine ... responses to iron deprivation are poorly understood. In res ponse to iron deficiency, S. cerevisiae Cth2, an RNA-binding protein conserved in plants and mammals, is upregulated 200-fold....
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Báo cáo y học: " International perspectives on intensive care at the end-of-life: the futility movement seems alive and well" ppt
... clinicians’ reasoning.I find this book most interesting in the insight that it providesinto the American experience with confronting the principle ofmedical futility. In 1991, the American ... American Thoracic Societydefined a life-sustaining intervention as futile ‘… if reasoningand experience indicate that the intervention would be highlyunlikely to result in a meaningful survival for ... important issuesis that it demonstrates considerable variability in therationales toward application of the principle of medicalfutility, and variation in the way in which resource constraintseffect...
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Báo cáo y học: "Differential effects on BAFF and APRIL levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis" pot
... RJ, Kurtin PJ, Goronzy JJ,Weyand CM: BLyS and APRIL in rheumatoid arthritis. J ClinInvest 2005, 115:3083-3092.14. Jonsson MV, Szodoray P, Jellestad S, Jonsson R, Skarstein K:Association between ... inhibited by theincreased availability of BAFF, which by binding to the BAFF-R induces upregulation of anti-apoptotic proteins [4,34].Another concern is the association of increased BAFF andAPRIL ... lym-phoid organs [6] and is inducible by cells of myeloid origin(monocytes, macrophages, neutrophils, and dendritic cells)and also by osteoclasts (reviewed by Ng and colleagues [3]and Dillon and colleagues...
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Báo cáo y học: "Early Reversal of experimental colitis disease activity in mice following administration of an adenoviral IL-10 vector" pps
... function bytransforming growth factor beta, interleukin-4, and inter-leukin-10. Ann N Y Acad Sci 1993, 685:713-739.20. Bogdan C, Vodovotz Y, Nathan C: Macrophage deactivation byinterleukin 10. ... IL-10 preventsinflammation and mucosal damage in animal models of colitis and in human colitis. Interleukin-10(IL-10), an endogenous anti-inflammatory and immunomodulating cytokine, has been ... Granowitz EV, Shapiro L, Vannier E, Lonnemann G,Angel JB: A randomized, controlled trial of IL-10 in humans.Inhibition of inflammatory cytokine production and immuneresponses. J Immunol 1995,...
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Báo cáo y học: " Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered" pptx
... associated with an increase in muscle mass probably mediated by inhibition of muscleproteolysis rather than by stimulation of muscle proteinsynthesis [27]. Inhibition of muscle proteolysis, in parti-cular ... proteolysis in cultured L6myotubes. Shock 1998, 10:298-306.39. Yin HN, Chai JK, Yu YM, Shen CA, Wu YQ, Yao YM, et al: Regulation ofsignaling pathways downstream of IGF-I/insulin by androgen in skeletalmuscle ... conti nuously maint aine d at37°C. Rats received an intramuscular injection of eithersaline or methylprednisolone (5 mg/kg, corresponding~0.8 mg/kg in humans [19]) or 30 mg/kg, (corresponding~4.8...
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Báo cáo y học: " Cost analysis of an integrated disease surveillance and response system: case of Burkina Faso, Eritrea, and Ma" pot
... activities.§ Investigation, verification and laboratory confirmation of suspected cases.† Other support activities include training, supervision, communication and coordination.¶Laboratory and treatment ... [20,21]. In this study, we measured the incrementalcosts of setting-up and implementing an integrated sur-veillance and response strategy in Burkina Faso, Eritreaand Mali. In each country, the ... activities include detection, report, analysis and feedback¶Response activities include field investigation and laboratory confirmation of suspected cases and treatment of confirmed cases. In Burkina...
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Báo cáo y học: "New and conventional strategies for lung recruitment in acute respiratory distress syndrome" pps
... erent types of lung injury, mainly pulmonary and extra-pulmonary origin; 2) diff erences in the severity of lung injury; 3) the transpulmonary pressures reached during recruitment maneuvers; ... recruitment maneuver in models of pulmonary and extrapulmonary ALI, induced by intratracheal and intraperitoneal instillation of Escherichia coli lipo poly-saccharide, with similar transpulmonary pressures. ... lung in one animal with acute lung injury induced by lavage. Left panel: Perfusion map after induction of injury and mechanical ventilation according to the ARDS Network protocol. Right panel:...
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Báo cáo y học: "Toll-like receptors and NOD-like receptors in rheumatic diseases" pdf
... and IFNIR as a consequence of the inability ofmacrophages to efficiently degrade cytosolic DNA [54].Ankylosing spondylitis, TLR2 and TLR4Ankylosing spondylitis is a multifactorial and polygenicinflammatory ... Asp299Gly and Thr399Ile polymorphisms andankylosing spondylitis [56], but no link with the Asp896Glypolymorphism [57]. The functional consequences of thesepolymorphisms and the mechanistic link ... hereditary periodicfever syndromes in humans, including Mucke–Wells syn-drome, chronic infantile cutaneous neurologic articular syn-drome and familial cold-induced autoinflammatory syndrome[8]....
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Báo cáo y học: " Roles of XB130, a novel adaptor protein, in cancer" pps
... These findingssuggest that XB130 could be a novel oncoprotein in cancer. A deeper understanding of these mechanismsBinding PartnerpYpYXB130pYpYXB130Binding Partnerinactiveactivetyrosine ... These findings indicate thatXB130 has an important role in the regulation of tyrosinekinase-mediated signaling.Roles of XB130 in cell cycle and survivalTo investigate the role of XB130 in cancer ... F-actinmeshwork and is involved in the motility and invasiveness of cancer cells. Gene expression profiling identified 246genes significantly changed in XB130 short hairpin RNA transfected thyroid...
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