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Báo cáo y học: "Clara cell protein in bronchoalveolar lavage fluid: a predictor of ventilator-associated pneumonia" pot

Báo cáo Y học: SF2/ASF protein inhibits camptothecin-induced DNA cleavage by human topoisomerase I potx

Báo cáo Y học: SF2/ASF protein inhibits camptothecin-induced DNA cleavage by human topoisomerase I potx

... cleaved by htopo I (Fig. 4, lanes 2 and 6).However, it is clearly visible that SF2/ASF only slightlyinhibited the cutting of DNA by either HindIII or RsaI. AtthesameconcentrationofSF2/ASFinthepresenceofhtopo ... 3, htopo I, digested with proteinaseK; 4, htopo I + SF2/ASF, no proteinase K; 5, htopo I + SF2/ASF, digested with proteinase K.Fig. 5. Inhibition of kinase activity of htopo I by DNA and campto-thecin. ... htopo I, 0.92 pmol SF2/ASF, 10 U HindIII and 15 U RsaIwere used. The mixtures were incubated for 30 min at 30 °C. Lanes: 1,HindIII; 2, HindIII + htopo I; 3, HindIII + SF2/ASF; 4, HindIII +htopo...
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Báo cáo y học: "Endothelial cell phenotypes in the rheumatoid synovium: activated, angiogenic, apoptotic and leaky" pps

... bymacrophages, but also localise to endothelial cells and lymphocytes [97–99]. The type 1 IL-1 receptor isexpressed by the endothelium, by the lining cells and byother sublining cells in the ... macrophages in the RA lining layer and in the sublining, with someendothelial and lymphocyte staining [76,100–102]. The TNF receptors p55 and p75 are expressed by endothelialcells and a variety of other ... endothelial cells, as shown by in situ hybridisation[120]. There is only scant expression of these enzymes in normal synovia. MMP-3 (stromelysin) mRNA mainly occurs in the lining layer in RA synovia...
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Báo cáo y học: "Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow" doc

... sIL-1R, increasing the binding affinity of IL-1α and IL-1β to type II sIL-1R byapproximately 100-fold, while leaving unaltered the lowbinding affinity of IL-1Ra to type II sIL-1R, thus enhancinginhibition ... arebroader and include activating or increasing the level of factors able to inhibit proinflammatory cytokines or othercatabolic factors.Interleukin-1βFor specific inhibition of the production/activity ... approaches to improving treatment of OA. The first section reviews the mostReviewMost recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrowJean-Pierre...
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Báo cáo y học: "Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration" ppt

... participated in the design of the study, performed the majority of the laboratory work and analysis, and drafted the manuscript. AJF participated in the design of the study andinterpretation of data. JAH ... CCT ACC ACG AAA GCA GAT C 3'5' 6 FAM – CCC AGG ACA GAC CTA CGA TGC CAC C – TAMRA 3'5' GCC GGG ACA CAC GGA GTA 3' 99.74%ADAMTS 5, a disintegrin and metalloprotease ... 74 years), 10 intermediate degenerate discs (4 aged 37 years, 1 aged 44 years, 1 aged 49 years, 2 aged 62 years, and 2 aged 74 years), and 1 severely degenerate disc (aged 49 years). Spearman...
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Báo cáo y học: "Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis" doc

... 3'-gttcgggaaccggattattta-3';CDC2: 5'-ggtcaagtggtagccatgaaa-3' and 3'-ccaggagggata-gaatccaag-5'; and MKI67: 5'-ccccaaccaaaagaaagtctc-3' and3'-gactaggagctggagggctta-5'.Histopathology ... 5'-gcccagctatgaactccttct-3'and 3'-tgaagaggtgagtggctgtct-5'; INDO: 5'-ggtcatggagatgtc-cgtaa-3' and 3'-accaatagagagaccaggaagaa-5'; GTSE1: 5'-acgtgaacatggatgacccta-3' and ... allowedduring the duration of the study. Adalimumab therapy was initiated at a dosage of 40 mg sub-cutaneously every other week. Disease activity at baseline (T0)and 12 weeks after initiation of therapy...
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Báo cáo y học: " Acinic cell carcinoma in pregnancy: a case report and review of the literature" docx

... this report, and she has had no recurrence of her acinic cell carcinoma. Discussion Acinic cell carcinoma (ACC) is a rare malignant epithe-lial salivary neoplasm of a ductal cell origin. It is a ... surgeon of the case, and heparticipated in the editing of the article and in reviewing the literature. AAOwas involved in data collection, literature review, and in editing the article.All authors ... lar maligna nt lymphadenopa thy. The size of the rec urrent acinic cell carcinoma and the ipsilateral malig-nant cervical lymphadenopathy progressively increaseduntil the end of her pregnancy....
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Báo cáo y học: "CD8+ T lymphocytes in bronchoalveolar lavage in idiopathic pulmonary fibrosis" ppt

... zdaniil@med.uth.gr* Corresponding author AbstractBackground: Recently it was shown that in Idiopathic Pulmonary Fibrosis (IPF) tissue infiltratingCD8+ T lymphocytes (TLs) are associated with breathlessness ... existingdiscrepancies on the pathogenetic role of inflammatorycells in IPF patients. Although the current pathogenetictheories in IPF sustain progress despite paucity of intersti-tial inflammation, ... TLs areknown to produce type 2 cytokines such as interleukin-4and interleukin-5 [27]. Recently, it has been hypothesizedthat in patients with IPF an excessive recruitment of CD8+TLs may...
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Báo cáo y học: "B cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow-up open-label trial" docx

... ARTIC LE Open AccessB cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow -up open-label trialSilvia ... progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow -up open-label trial. Arthritis Research& Therapy 2010 12:R54.Submit your next manuscript ... organs. B cells, with their multiple mechan-isms as antibody-producing cells, antigen-presentingcells and profibrotic and proinflammatory cytokines pro-ducing cells (IL-6, IL-4, transforming growth...
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Báo cáo y học: " Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery" pps

... lung injury [12]. Pentoxifylline administration topatients with ischemic cardiomyopathy inhibited pro-inflammatory cytokines and reduced apoptosis bydecreasing TNF-α and Fas concentrations in ... [15].Pentoxifylline probably prevents apoptosis both by inhib-iting TNF-α production and by diminishing reactive oxy-gen species in our model. The extrinsic pathway can beactivated during chronic ... persistent pulmonary hypertension and acute pulmonary edema,both of which can be related to endothelial cell (EC) dys-function [4-6].ECs play a pivotal role in preserving vascular integrity and preventing...
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Báo cáo y học: " Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1" docx

... control T cells are equally susceptible to HIV-1 in the absence of DC, demonstrating that the DC-mediated transmission itself is impaired, instead of the ability of HIV-1 to infectthese cells. The ... smallernumber of T cells that is tightly attached to DC will result in a decrease of the window of opportunity for HIV-1 transmission. Furthermore, it is likely that the creation of an 'infectious synapse' ... Deficiency type1 (LAD-1) patients. Results: We clearly show that DC-mediated HIV-1 transmission to LAD-1 T cells is impaired in comparison to healthy controls. Furthermore, HIV-1 transmission to T cells...
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Báo cáo y học: " T cell activity in successful treatment of chronic urticaria with omalizumab" pdf

... assessment of PHA-stimulated adenosine triphosphate (ATP) activity as maker of CD4+ T cells activity in peripheral blood cells. We present the case report of a 35-year-old woman with a history of chronic idiopathic ... Allergy entitled “Downregulation of the high-affinity IgE receptor associated with successful treatment of chronic idiopathic urticaria with omalizumab” [1]. The study demonstrated theeffectiveness ... evaluated the effects of omalizumab therapy onthe activity of peripheral blood CD4+ T cells from the patient, in order to determine the potential modification of anti-IgE therapy on the process of...
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Báo cáo y học: "Directed cell migration in the presence of obstacles" doc

... consideration. The dynamics of cell movement very close to the obstacle surface are alsoinfluenced by short-range hydrodynamic interactionsbetween the two. In the interest of having an analyticallytractable ... completely determined by the local chemical gradient. We now relax this condition byrequiring that the cell& apos;s motion is partly determined byintrinsic noise and partly by the gradient. The cell& apos;smotion ... zero. The effect of noise on the capture probability In this section we study the effect of noise on the obstacleavoiding abilities of chemotactic cells. In the deterministiccase, the cell& apos;s...
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Báo cáo y học: "Clara cell protein in bronchoalveolar lavage fluid: a predictor of ventilator-associated pneumonia" pot

... AccessClara cell protein in bronchoalveolar lavage fluid: a predictor of ventilator-associated pneumonia?Marijke J Vanspauwen1, Catharina FM Linssen1*, Cathrien A Bruggeman1, Jan A Jacobs1,4, ... infectionresulted in increased pulmonary and systemic inflamma-tion. Mechanical ventilation itself may at least partly beresponsible for an increase in CC-10 concentrations in all intubated patients. We hypothesise ... Early-onset VAPwas defined as VAP occurring within 7 days after intuba-tion, whilst late-onset VAP was defined as VAP occurringmore than 7 days after intubation [13,25].Collection of clinical dataCollected...
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Báo cáo y học: " C-reactive protein in critically ill cancer patients with sepsis: influence of neutropenia" doc

... response indepen-dently of the treatment of infection [29-33]. In the present study, we clearly demonstrate that CRP,a major acute phase reactant protein, increases markedly in profoundly immunosuppressed ... antibio-tic therapy was similar in neutropenic and non-neutro-penic septic critically ill cancer patients. Since inadequately treated infections can be rapidlyfatal in neutropenic cancer patients, ... 15:R129http://ccforum.com/content/15/3/R129Page 3 of 7 RESEARCH Open Access C-reactive protein in critically ill cancer patients with sepsis: influence of neutropeniaPedro Póvoa1,2*, Vicente Ces...
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Báo cáo y học: "Complex cell behaviors in development: recent progress and emerging challenges" pptx

... probablypresent during cell signaling is kept under control allowingcoordinated cell movement. This was followed by inspiringtalks in which powerful advances in imaging, cell labeling and molecule ... captured in theopening talk by Cornelia Bargmann (Rockefeller University,New York, USA) describing work on oxygen sensing in nematodes. In her model, sensory inputs detected by the tail and head ... Biology 2005, 6:331commentreviewsreportsdeposited researchinteractionsinformationrefereed researchMeeting reportComplex cell behaviors in development: recent progress and emerging challenges...
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