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Báo cáo y học: "Pediatric trauma deaths are predominated by severe head injuries during spring and summer" ppt

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Báo cáo y học: "PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers"

... 3(4):117-123 â2006 Ivyspring International Publisher. All rights reserved Review PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers? Joseph ... non-responsive to the treatment. It was therefore proposed that PARP-1 inhibitors might be the long-sought genetically specific drugs that are both safe and effective for treating BRCA1/2-associated breast ... with cytotoxic drugs by increasing the sensitivity of the tumors to these agents. Indeed, it has been shown that PARP-1 inhibitors not only significantly enhance the anti-tumor efficacy of the...
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Báo cáo Y học: Characterization of the 105-kDa molecular chaperone Identification, biochemical properties, and localization pptx

Báo cáo Y học: Characterization of the 105-kDa molecular chaperone Identification, biochemical properties, and localization pptx

... detected in the soluble and insoluble fractions of renalcortex and renal papilla. The 105-kDa protein in the kidneyis specifically located in the medulla, and the localization of the 105-kDa protein ... the cyto-plasm of the germ cells. The 105-kDa protein maycontribute to the stabilization of p53 and prevent the potential induction of apoptosis by p53. On the contrary, localization and expression ... and secondary structure prediction of the 105-kDa protein, HSP90, APG-1, and OSP94. For the hydropathy profiles of APG-1 or OSP94, we used the hydrotable of Hopp and Woods. The secondary structureprediction...
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Báo cáo y học: "Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study" pptx

... with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control studyHarald E Vonkeman1, Robert W Fernandes2, ... with cardiovascular co-morbidity. Proton-pump inhibitors are associated with a reduced risk for NSAID ulcer complications.IntroductionTreatment with non-steroidal anti-inflammatory drugs(NSAIDs) ... primary prevention of NSAID -associated gastropathy has so far only been proven for subjective symp-toms and surrogate endpoints, such as dyspepsia and endo-scopic ulcers, and in the secondary...
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Báo cáo y học: "Inhibition of allogeneic inflammatory responses by the Ribonucleotide Reductase Inhibitors, Didox and Trimidox" pot

... demonstratehere, the ability of these compounds to inhibit the secre-tion of the crucial cytokines, IL-2, IL-6, TNF-a and IFN-g thereby reducing the collateral damage caused by the d irect actions of these ... of the ribonucleotide reductase inhibitors, Didox and Trimidox, to act as inhibitors of inflammatory responses by both inhibiting the prolifera-tion of T-cells and the production of cytokines.DiscussionIn ... IL-4 by approximately 40%, 60% and 90% respectively. Levels of cytokines were reduced to or below that of NC by treat-ment with a 50 μM dose. Together, these data demon-strate the ability of the...
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Báo cáo y học: "Early Migrating leukocytes are the source of Peroxiredoxin V during inflammation in the airway" potx

... epithelial lining during inflammation. However, dur-ing the development of inflammation, multiple leukocytes appeared in the lung parenchyma, most of which highly expressed PRXV (Figure 2). Therefore, ... up-regulated during inflammation in tissues of the lung nor the identity of the cells that are the source of PRXV pro-duction are known.We therefore investigated the effects of gram-negative bac-terial ... migration of leukocytes in the tracheal epithe-lium changed mRNA levels of PRXV; f-MLP slightlyincreased expression of PRXV protein in the tracheal epi-thelium. In mice, bacterial inflammation of the...
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Báo cáo y học: " Post-menopausal vaginal bleeding caused by carcinoma of the appendix: a case report" ppt

... examination of the tissue removed at laparotomy revealed an adenocarcinoma of the appendix. She was treated with adjuvant radiotherapy and with palliative chemotherapy after 14 months because of intra-abdominal ... mucinous cystadenocarcinomas and adenocarcinomas. Primary adenocarcinomas of the appendix are approximately 10 times less common than appendiceal carcinoids [8].Mostly appendiceal carcinomas present ... appears that this is the first published case of a post-menopausal primary appendiceal carcinoma presenting with vaginal blood loss. Case presentation: A 75-year-old Caucasian woman with a...
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Báo cáo y học: " Implementing clinical guidelines in psychiatry: a qualitative study of perceived facilitators and barriers" pptx

... qualitative methods in this study was to gain a deeper understand-ing of barriers and facilitators for implementing clinical guidelines in psychiatry in a multidisciplinary team. Anunderstanding ... to clinical guidelines and new actionPositive attitudes and beliefs regarding guidelines and new action Perceived limited validity of guidelines Fear of loss of autonomyFear of standardization ... al.: Implementing clinical guidelines in psychiatry: a qualitative study of perceived facilitators and barriers. BMC Psychiatry2010 10:8.Publish with BioMed Central and every scientist can read...
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Báo cáo y học: " The potential role of appetite in predicting weight changes during treatment with olanzapine" ppt

... in conjunction with adjunctive pharmacotherapeutic agentsmight l imit weight gain during antipsycho tic drugtherapy [15].An understanding of the role of appetite changes in weight gain during antipsychotic ... manage them. Here we test the hypothes is that changes in appetite might be indicative of a patient’ s weight gain during treatment with olanzapine.MethodsPresented are secondary analyses examining ... betweenchange in appetite and change in weight were observed in Study 1, which was also the shortest study included in the current analyses and the only study in whichincreased appetite was observed...
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Báo cáo y học: " Eradication of intractable malignant ascites by abdominocentesis, reinfusion of concentrated ascites, and adoptive immunotherapy with dendritic cells and activated killer cells in a patient with recurrent lung cancer: a case report" pps

... ReportsOpen Access Case report Eradication of intractable malignant ascites by abdominocentesis, reinfusion of concentrated ascites, and adoptive immunotherapy with dendritic cells and activated killer ... oliguria, but causehypovolemia, hypoproteinemia and general malaise. Tocontrol ascites, drainage and intra-abdominal chemother-apy are often employed for those patients, but eradication of ascites ... of a terminal stage in several malignant diseases. Tocontrol ascites, drainage and intra-abdominal chemotherapy are often used in those patients but eradication of ascites is difficult and prognosis...
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Báo cáo y học: " Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways " ppt

... Mol Biol 2 010 , 42:3-8.doi :10 .11 86 /14 65-99 21- 12 -19 Cite this article as: North et al.: Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness ... Respiratory Research 2 011 , 12 :19 http://respiratory-research.com/content /12 /1/ 19Page 8 of 14 induced exacerbations of respiratory symptoms. In thisstudy we demonstrated further augmentation of arginase activity ... Research 2 011 , 12 :19 http://respiratory-research.com/content /12 /1/ 19Page 2 of 14 Facility, as previously described [16 ]. Goat anti -arginase 1 primary (sc -18 3 51) and donkey anti-goat secondary(sc-2042)...
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Báo cáo y học: "Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts" ppt

... chemokines and cytokines by fibroblasts, which subsequently canincrease the inflammatory infiltration of the tissue. In this study, IFNa2 upregulated TLR3 and T LR3-inducedIL-6 production. The increase ... expression in systemic sclerosis. J Invest Dermatol 2010, 130 :25 83- 25 93. doi:10.1186/ar3221Cite this article as: Agarwal et al.: Toll-like receptor 3 upregulation by type I interferon in healthy and ... deposi-tion in the bleomycin-induced skin fibrosis model [38 ].However, clinical trials of recombinant IFN-g or IFN-a in patients with SSc faile d to show substantial clinicalbenefit [39 -41]....
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Báo cáo y học: "Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex" potx

... in the presence of increasing concentrations of flavopiridol. The P-TEFb inhibitors DRB, seliciclib and flavopiridol release P-TEFb from the large formFigure 3 The P-TEFb inhibitors DRB, seliciclib ... study indicates that HIV-1 Tat is able to recruit P-TEFb out of the large form therebyreducing the quantity of large form within HIV-1 infectedcells [45]. Alternatively, the large form of P-TEFb ... large form of P-TEFb within cells as the inhibi-tors blocked kinase activity. P-TEFb may be released from the large form of the complex to compensate for the loss of P-TEFb activity. The P-TEFb...
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Báo cáo y học: "Conventional intramuscular sedatives versus ziprasidone for severe agitation in adolescents: case-control study" ppt

... and Adolescent Psychiatry and Mental HealthOpen AccessResearchConventional intramuscular sedatives versus ziprasidone for severe agitation in adolescents: case-control studyWilliam C Jangro, ... Posey DJ, Petti TA, McDougle CJ: Intramuscular Ziprasidone for acute agitation in adolescents. J Child AdolescPsychopharmacol 2004, 14:464-470.13. Staller JA: Intramuscular ziprasidone in youth: ... the first atypical antipsychotic agentavailable in parenteral form. In clinical trials for agitation in adults with psychotic disorders, it showed clinical effectwithin 15–30 minutes [8,9]....
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Báo cáo y học: "Global end-diastolic volume acquired by transpulmonary thermodilution depends on age and gender in awake and spontaneously breathing patient" ppt

... 12(page number not for citation purposes)Vol 13 No 6ResearchGlobal end-diastolic volume acquired by transpulmonary thermodilution depends on age and gender in awake and spontaneously breathing ... in detail. We investigated the relationship of the global end-diastolic volume (GEDV) acquired by transpulmonary thermodilution with age and gender in awake and spontaneously breathing patients.Methods ... adequately volume resuscitated [15]. The aim of the current study was to investi-gate the hypothesis that GEDVI acquired by transpulmonary thermodilution depends on age and gender in awake and spontaneously...
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Báo cáo y học: "Pediatric trauma deaths are predominated by severe head injuries during spring and summer" ppt

... researchPediatric trauma deaths are predominated by severe head injuries during spring and summerKjetil Søreide*1,2,3, Andreas J Krüger3,4, Christian L Ellingsen5 and Kjell E Tjosevik3,6Address: ... these are based, and rely, on the accu-rate reporting and coding practices among regions and hospitals. Autopsy practice may vary significantly amongregions, and thus trauma- related deaths may ... autopsy recordsfrom this 10-year period. Excluded were drowning, hang-ings, poisonings, intoxications, and deaths exclusivelycaused by asphyxia with no anatomic injuries, and deaths from burn injuries. Stavanger...
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