Báo cáo y học: " Kinetic modeling of tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targets" ppt
Báo cáo y học: " Kinetic modeling of tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targets" ppt
... developed kinetic models of the tricarboxylic acid cycle and glyoxylate bypass in Escherichia coli and Mycobacterium tuberculosis, and studied the effects of inhibition of various enzymes in the ... tricarboxylic acid cycle and glyoxylate bypass in Mycobacterium tuberculosis, and its application to assessment of drug targetsVivek Kumar Singh and Indira Ghosh*Address: Bioinformatics Centre, ... construction of a kinetic model of the TCA cycle and glyoxylate bypass in M. tuberculosis, and we study the likely metabolic conse-quences of inhibiting ICLs and ICD1-kinase. To the best of our knowledge,...
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Báo cáo Y học: Kinetic studies of human tyrosyl-DNA phosphodiesterase, an enzyme in the topoisomerase I DNA repair pathway pot
... of cofactor for TDP enzymaticactivity was examined by determining the specific activity of TDP by following the cleavage of 1 mM of substrate by0.125 lM of enzyme in reaction buffer containing ... therapeutic utility in treatingcancers that are refractory to camptothecin treatment. In order to understand the structure–activity relationship of TDP and to facilitate inhibitor screening in a highthroughput ... TDP and was confirmed by restriction enzymemapping and by nucleotide sequencing. The yeast TDPcoding sequence obtained in our study differs from the onepublished in GenBank in the following...
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Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx
... HSPG binding at thecell surface is required for maintaining LPL stability.LPL’s C-terminal domain also appears to be involved in the binding of the enzyme to receptors such as the LDLreceptor ... Strickland, D.K.(1994) The carboxyl-terminal domain of lipoprotein lipase binds to the low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor (LRP) and mediates binding of ... form without it. Amino acid substitutions in the C-terminal domain were made to address the functional roles of the C-terminal domain in heparin binding and in catalytic activity. We also provideexperimental...
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Tài liệu Báo cáo Y học: Kinetic study of sn-glycerol-1-phosphate dehydrogenase from the aerobic hyperthermophilic archaeon, Aeropyrum pernix K1 potx
... reduction by NAD+at 2.1 mMdihydroxyacetone phosphate and varyingNADH concentration; B-2, in hibitio n of dihydroxyacetone phosphate reduction byNAD+at 0.32 mMNADH and varyingdihydroxyacetone ... concentration;C-1, inhibition of dihydroxyac etone phos-phate reduction by Gro1P at 2.1 mMdihy-droxyacetone p hosphate and varying NADHconcentration; C-2, Inhibition of dihydrox-yacetone phosphate ... competitiveinhibitor against NAD(P)H and as a noncompetitiveinhibitor against dihydroxyacetone phosphate. This kinetic data indicates that the catalytic reaction by glycerol-1-phosphate dehydrogenase...
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Tài liệu Báo cáo Y học: Kinetic properties of bifunctional 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase from spinach leaves pdf
... mixture to inactivate the enzymes, and the Fru-2,6-P2content of a 10-lL sample of the resulting mixturewas determined by measuring its ability to activate PFP.For each determination of 6PF2K and ... min. The supernatant was adjusted to 3%poly(ethylene glycol) 4000 by adding 0.11 vol. of a 30%poly(ethylene g lycol) solution in buffer A . After 5 min,precipitated protein was removed by ... 20 min. The supernatant was adjusted to 15% poly(ethylene glycol) by the addition of 0.67 vol. of 30% poly(ethylene glycol) in buffer A, and after 10 mincentrifuged at 10 000 g for 20 min. The...
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Báo cáo Y học: Kinetic analysis of hydroxylation of saturated fatty acids by recombinant P450foxy produced by an Escherichia coli expression system docx
... substrate-accessing channel, and theirguanidinium and hydroxyl groups, respectively, play crucialroles in the binding of the substrate by interacting with thecarboxyl group of the substrate fatty acids ... essential for fixing the carboxylate of fattyacids is maintained by replacing Arg with Lys. However,hydrophobicity at the entrance to P450foxy should besignificantly increased as the result of the substitutions ... University of Tokyo, JapanCytochrome P450foxy (P450foxy, CYP505) is a fused pro-tein of cytochrome P450 (P450) and its reductase isolatedfrom the fungus Fusarium oxysporum, which catalyzes thesubterminal...
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Báo cáo khoa học: " Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation" pps
... achieved in both settings. This fits clinical experi-ence; 54 Gy of radiation to the brain/posterior fossa and 36 Gy to the spine has a high probability of curing medul-loblastoma. By adjusting ... arise early in the treatment course), it is occasionally necessary to sus-pend treatment of the spine temporarily while treatment of the brain continues. Since the brain and spine are in communication ... for in the model by incorporating modulatingefficiency factors for transfer of viable cells from the CSF to solid tumor and from solid tumor to CSF, γf and γt,respectively, which range in...
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Báo cáo y học: "Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites" potx
... by blocking target sites [34], or in trans,for example, by changing the secondary structure in thevicinity of the target site. In addition, a number of RNA-binding motifs have been linked to ... selecting a meaningfulcutoff for repo rting target sites. The empirical distribu-tions suggest an intuitive score cutoff of -0.1 or lower,since for scores closer to zero the probability of meaningful ... allows variability in seed region binding,including non-canonical seed base pairing; incorporat-ing a wide range of m icroRNA::site duplex and contex-tual features; training with an algorithm...
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Báo cáo y học: " Kinetic studies of HIV-1 and HIV-2 envelope glycoprotein-mediated fusion" potx
... Specificity of bindingwas demonstrated by sCD4 inhibition of CD4 binding and a lack of CXCR4 binding in the absence of sCD4 (datanot shown).These binding data were further corroborated by inhibi-tion ... strains (in contrast to HIV-1) are often able to infect cells CD4-inde-pendently. Since CD4-induced binding of soluble gp120molecules to CXCR4 was not very different between theHIV-1IIIB and ... rate of engagement of HIVgp120 with its coreceptor. Since the CD4-induced binding of gp120 proteins to CXCR4 is not very different betweenthe different strains, we surmise that in the intact...
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Báo cáo y học: "Economic modeling of the combined effects of HIV-disease, cholesterol and lipoatrophy based on ACTG 5142 trial data" pps
... Cost-effectiveness of lopinavir/ritonavir compared to atazanavir plus ritonavir in antiretroviral-experienced patients in the U.S.: Modeling the combined effects of HIV and Heart Disease. Clin Drug Invest ... included in the model. Randomized clinical trial results are the goldstandard for defining safety and efficacy of therapy, butare limited t o the relatively short duration of the study in comparison ... utility due to the effects of lipoatrophy on HRQOL. The results of the analysis of theutility values for patients with and without evidence of lipoatrophy are provided in Table 2.Lipoatrophy may...
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Từ khóa: mri measurement of cerebral water diffusion and its application to experimental researchbáo cáo y họcbáo cáo y họcbáo cáo y học cổ truyềnmẫu báo cáo y học cổ truyềnbao cao y hoc colchicinphan ban luan trong bao cao y hoc co truyenchen y bicker w wu j xie m lindner w simultaneous determination of 16 nucleosides and nucleobases by hydrophilic interaction chromatography and its application to the quality evaluation of ganoderma journal of agricultural and food chemthe basic features of the gimf and its application to a small open oil exporterthe bill of rights and its application to the statespreparation and properties of sio2 thin films by the sol gel method using photoirradiation and its application to surface coating for displayvascular hemodynamics of the carotid bifurcation and its relation to arterial diseasenetwork which depends on the proper operation of each individual component and its relation to other componentscultural intermixing the diffusion of gis and its application to coastal management in developing countriestheory of special relativity and its application to gpsBáo cáo quy trình mua hàng CT CP Công Nghệ NPVBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Sở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)Chiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015Đổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namMÔN TRUYỀN THÔNG MARKETING TÍCH HỢP