... change in
O
2
requirements, results in an increase in ERO
2
,
rendering ScvO
2
an interesting contributor to patient
monitoring. In critical illness, however, the ability of
tissue to increase ... Kline JA: Lactate
clearance vs central venous oxygen saturation as goals of early sepsis
therapy: a randomized clinical trial. JAMA 2010, 303:739-746.
13. Wenkui Y, Ning L, Jianfen...
... respectively. Interestingly,
an increase in virological response over time after the discontinuation of thymosin could be observed (p=0.02) [40]. The doses of
thymosin α-1 in this meta-analysis are ... nucleoside
analogues, lamivudine and adefovir dipivoxil. The immunomodulators act by promoting cytotoxic T cell activity for lysis of
infected hepatocytes and by stimulating cytokine pr...
... transcription factors that
share a highly conserved DNA binding domain (Ets
domain). ETS factors are involved in regulating a wide
variety of biological processes including normal develop-
ment and differentiation ... cells. We and others have
observed that Ets-1 is induced in VSMC and endothelial
cells in response to a variety of stimuli including Angi-
otensin II (Ang II), PDGF-BB,...
... be
explained in several ways. First, the interventions do not
affect outcome. Certainly, there is mounting evidence that
some of the studied interventions, such as application of the
pulmonary artery ... outcome.
Second, any beneficial effects are offset by unwanted side
effects. For example, better titration of care secondary to
information gained by pulmonary artery catheter use may be...
... siRNAs
and (iii) silencing movement in the infected host, which
may be an indirect hint for the efficiency of anti-viral
silencing.
Anti-viral RNA silencing in invertebrates
Insect
Many arthropod species ... naturally tamed by
a silencing-related mechanism. They rather found discrete
species of small RNAs encoded by the Epstein-Barr Virus,
very akin to endogenous host-encoding small RNAs...
... confidence interval 1.1
to 10.2) after adjusting for differences between groups.
Commentary
Sodium and brain injury: do we know what we are doing?
David A Zygun
Departments of Critical Care Medicine, ... between hyper-
natremia and mortality in patients with traumatic brain injury. This
mandates a re-evaluation of routine administration of agents such
as hypertonic saline for the mana...
... what do we actually know?
What are the consistent threads? e following sum-
marizes what we know with certainty.
First, hyperglycemia is toxic. Falciglia and colleagues
convincingly showed in ... frequency
of blood glucose monitoring, variability in the accuracy
of glucometer devices used, variability in the methods
used to defi ne euglycemia, whether insulin dosing was
dri...
... and genotyping of HIV RNA was
performed by nested RT-PCR and an in- house sequencing
assay as described elsewhere [4]. The interpretations of
genotyping data and subtyping were performed using
Smartgene™ ... ksteegen@its.jnj.com; Stanley Luchters - stanley.luchters@ugent.be; Kenny Dauwe - kenny.dauwe@Ugent.be;
Jacqueline Reynaerts - jacqueline.reynaerts@ugent.be; Kishor Mandaliya - kmandali...
... co-receptor usage may be involved in viral selection
following initiation of therapy.
Discussion
In our study we observed comparable viral decay within
all CD4
+
lymphocyte sub-populations in the peripheral
blood, ... immunodeficiency virus type 1 V3 domain
to support the syncytium-inducing phenotype: analysis by single amino
acid substitution. J Virol 1992, 66:6777-6780.
43. Nicholso...
... by a continued reduction in the proportion of
death due to ADI’s in HIV infected individuals [10,11].
Life-expectancy of individuals initiating HAART in
British Columbia (BC), Canada has continued ... to
this increase in life-expectancy is unknown.
InthisstudyweexaminedtrendsinreportedADIs
among participants who initiated HAART in the BC
HIV/AIDS Drug Treatment Program during the ye...