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Báo cáo y học: "Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock" pptx

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Báo cáo y học: "Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock" pptx

... (Vd), such as severe sepsis and septic shock. The primary aim of this study was to determine whether 25 mg/kg (total body weight) of amikacin is an adequate loading dose for these patients. Methods: ... regimen for amikacin in patients with severe sep-sis and septic shock. We also evaluated the impact of body weight, and specifically of an IBW-compared with aTBW-based regimen, on the optimization ... evaluate the beneficial effects of this strategyon the outcome of sepsis patients. Finally, we did not directly measure the body weight, and inaccurate weight estimation may have occurred for some of...
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Báo cáo y học: "Revisiting the Dexamethasone Suppression Test in unipolar major depression: an exploratory study" doc

... ZRcontributed in the analysis of the data and to interpreta-tion and the draft and the final paper. CF and AI contrib-uted in the design of the protocol, the gathering of the data and the final paper.References1. ... protocol, gathered and analysed the data and contributed to interpretation and the draft and the final paper. XG contributed in the analysis of the data and to interpretation and the draft and the final ... to the investigation of this relationship and especially to the association of clinical symptoms with the different characteristics of DST. The aim of the present study was to investigate the...
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Báo cáo y học: "Revisiting the pathogenesis of podagra: why does gout target the foo" docx

... the hypothesis that the association of gout and OA occurs at local joint sites and relates to the co-loca-tion of MSU crystal deposits and cartilage lesions. Speci-fically, they question the ... toFigure 1 Distribution of joints typically affected by gout(reproduced with the permission of the author and the RoyalCollege of General Practitioners: Roddy E, Doherty M. Gout. In:RCGP Guide ... to MSU crystal nucleation, the authorshypothesised that local trauma indirectly enhances crystalnucleation by lowering synovial pH [22]. Hence, the sus-ceptibility of the foot to physical trauma...
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Báo cáo y học: "Revisiting Lynam’s notion of the “fledgling psychopath": are HIA-CP children truly psychopathic-like" ppsx

... 2007,36:269-275.7. Cleckley H: The Mask of Sanity: An Attempt to Reinterpret the So-CalledPsychopathic Personality. Oxford: Mosby 1941.8. Lorber MF: The psychophysiology of aggression, psychopathy, and conduct ... Emotion and psychopathy: startling new insights.Psychophysiology 1994, 31:319-330.55. Frick PJ: Using the construct of psychopathy to understand antisocial and violent youth. In The Psychopath: Theory, ... that anyone wouldargue for the sufficiency of impulsivity in distinguishingyouth at risk for psychopathy.Further difficulty for Lynam’s model emerged with respect to emotional reactivity to...
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Báo cáo y học: "Revisiting the value of pre-hospital tracheal intubation: an all time systematic literature review extracting the Utstein airway core variables" pptx

... report the occurr ence and per-formance of T I within their system and therefore are notreflective of the effects or efficiency of pre-hospital TI.Several studies have focused on the intricacy of ... traditional RSI. The presence or absence of drug assistance and the availabil-ity and dose of specific agents are likely to influence the success rate of T I and the rate and severity of adverseevents. ... and abstracts of the records for eligibility. The full texts of al lpotentially relevant studies were obtained, and tworeviewers (HML and MR) assessed whether each studymet the eligibility criteria. The...
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Báo cáo Y học: Monitoring the structural consequences of Phe12 fi D-Phe and Leu15 fi Aib substitution in human/rat corticotropin releasing hormone Implications for design of CRH antagonists pdf

Báo cáo Y học: Monitoring the structural consequences of Phe12 fi D-Phe and Leu15 fi Aib substitution in human/rat corticotropin releasing hormone Implications for design of CRH antagonists pdf

... residue for the final family isgiven in Fig. S1. Fig. 3A shows the family of 40 structures and Table 1 contains a summary of statistical data indica-ting the quality of the 40 models and the average ... A˚(heavy atoms) for the mean structure. The NOE distance penalty function for the family of 40structures is 0.42 ± 0.03 A˚2 and 0.44 A˚2 for the meanstructure. The corresponding values for ... syndrome, inflammatory dis-eases, pre-eclampsia or preterm labour, anxiety and depres-sion and a potentially great number of other disorders.We have previously described the synthesis and the biological...
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Báo cáo Y học: Differential scanning calorimetric study of myosin subfragment 1 with tryptic cleavage at the N-terminal region of the heavy chain pdf

Báo cáo Y học: Differential scanning calorimetric study of myosin subfragment 1 with tryptic cleavage at the N-terminal region of the heavy chain pdf

... unfolding of S1 species with the heavy chain cleaved by trypsin at specific, well-defined sites.Thermal unfolding of S1 cleaved by trypsinin the absence of nucleotidesFirst, the effects of the tryptic ... dramatically decreases the thermal stability of S1 The results of this work show that tryptic cleavage betweenArg23 and Ile24 itself dramatically decreases the thermalstability of S1 by shifting its thermal ... increase of its thermal stability. Furthermore, in the presence of F-actin, another myosin fragment with verylow thermal stability, MyoIE700 (i.e. the isolated motordomain of D. discoideum myosin...
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Báo cáo Y học: Expanding the scorpion toxin a-KTX 15 family with AmmTX3 from Androctonus mauretanicus pptx

Báo cáo Y học: Expanding the scorpion toxin a-KTX 15 family with AmmTX3 from Androctonus mauretanicus pptx

... site seems to increase with the number of positivelycharged residues in the N-terminal half of these toxins (six for AmmTX3 and Aa1, five in BmTX3) and with the hydrophobicity of certain residues ... Baker, and all other analytical reagents, from Merck. The pyroglutamate aminopeptidase was from Boerhinger. The water used for the preparation of solutions and bufferswas purified with the Milli ... brain. The affinity of AmmTX3 for its binding site was higher than that of 125I-labelled sBmTX3 [8], and that observed for Aa1 in the competition experiments reported here. The affinity for the binding...
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Báo cáo Y học: Reconstructing the replication complex of AcMNPV pdf

Báo cáo Y học: Reconstructing the replication complex of AcMNPV pdf

... with 2 lg of the reporter plasmid pCAPCAT, and either 0.5 lg of each of the clones of the overlapping AcMNPV k libraryor 1.0 lg of each plasmid of the overlapping lef library asdescribed by ... mMphenyl-methylsulfonyl fluoride] at 4 °C for 30 min with agitation. The lysate was centrifuged at 12 000 g for 2 min, and 10 lLsupernatant were reserved for immunoblot analysis of the total lysate. ... aportion of the origin of replication hr5. Two-hybrid yeastconstructs were generated by PCR of each lef and insertioninto the EcoRI and XhoI sites of plasmids PJB4-5 and PEG202, respectively, using...
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Báo cáo Y học: Optimizing the delivery systems of chimeric RNA . DNA oligonucleotides Beyond general oligonucleotide transfer ppt

Báo cáo Y học: Optimizing the delivery systems of chimeric RNA . DNA oligonucleotides Beyond general oligonucleotide transfer ppt

... endosomes and be transported easily in the cytoplasm. Fourth, theyshould enter the nucleus easily. For transfection in vivo,thisis one of the most important hurdles. Finally, cytotoxity isanother ... problem. Only low or nontoxic deliverysystems could be used in humans. Therefore, we must testdifferent delivery systems on RDOs, and try to lower theircytotoxity and improve their efficiency.FUTURE ... alignment. The DNA strand isresponsible for the correction, while the RNA strand stabilizes the structure. The RDO designed for reacting with the sense strand is moreefficient than that for the antisense...
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