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Báo cáo y học: "A plea for balanced reporting" doc

Báo cáo Y học: A model for recognition of polychlorinated dibenzo-p-dioxins by the aryl hydrocarbon receptor docx

Báo cáo Y học: A model for recognition of polychlorinated dibenzo-p-dioxins by the aryl hydrocarbon receptor docx

... SapienzaÕ, Roma, ItalyLigand binding by the aryl hydrocarbon receptor (AhR), a member of the bHLH-PAS family of transcriptional reg-ulatory proteins, has been mapped to a region within the second ... ail: Anna.Tramontano@uniroma1.itAbbreviations: AhR, aryl hydrocarbon receptor; PYP, photoactiveyellow protein; LBD, ligand binding domai n; mAhR, mouse aryl hydrocarbon receptor; PCDD, polychlorinated ... lowerthan mAhR [19]; the AhR-1 ortholog of Caenorhabditiselegans (AhR-1C.E.), neither photoafđnity labeled by a dioxin analog, nor activated by b-naphto¯avone in a yeastsystem [20]; the rainbow...
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Báo cáo y học: "A need for a ‘whole-istic functional genomics’ approach in complex human diseases: arthritis" pptx

... data in a way that aids their interpreta-tion. Integrating various incompatible bioinformatics plat-forms is essential. Such efforts are currently under way bythe Interoperable Informatics Infrastructure ... cum calore et dolor]) as an entity using a singularrather than a plural noun, implying that it might be a singleprocess or a type of process. The avascular, alymphaticand aneural human OA-affected ... debate on OA or osteoarthrosis based on theCommentary A need for a ‘whole-istic functional genomics’ approach in complex human diseases: arthritisAshok R AminHospital for Joint Diseases/NYU...
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Báo cáo y học: "A protocol for classifying normal- and flat-arched foot posture for research studies using clinical and radiographic measurements" pps

... protocol for classifying normal- and flat-arched foot posture for research studies using clinical and radiographic measurementsGeorge S Murley*1,2, Hylton B Menz2 and Karl B Landorf1,2Address: ... decreases with flat-arched foot posture; angle B, C and D increase with flat-arched foot posture, compared to the normal- arched foot posture. Normal-arched foot Flat-arched foot AA B D ... http://www.jfootankleres.com/content/2/1/22Page 11 of 13(page number not for citation purposes)Screening protocol for normal- and flat-arched foot postureFigure 8Screening protocol for normal- and flat-arched...
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Báo cáo y học: " A questionnaire for determining prevalence of diabetes related foot disease (Q-DFD): construction and validation" potx

... and 5th toes and the plantar aspect of the 1st and 5th metatarsophalangeal joints) and assessment for vascu-lopathy by determining bilateral Ankle Brachial Indices(using an 8 mHz hand ... purposes)Journal of Foot and Ankle ResearchOpen AccessResearch A questionnaire for determining prevalence of diabetes related foot disease (Q-DFD): construction and validationShan M Bergin*1,2, Caroline ... standard blood pres-sure cuff and sphygmomanometer) and manual palpa-tion of pedal pulses. The presence of foot deformity orpressure areas was recorded, as was history of amputation and past...
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Báo cáo y học: " A method for studying decision-making by guideline development groups" potx

... ourresearch questions, prior to the main analysis phase. Thisinvolves systematically reducing data via application of a coding frame, developed from a broad thematic analysisof a subset of data, ... permit a compre-hensive analysis of social-psychological influences onGDGs. Additionally, reliance upon any one particularanalytic method in isolation may limit the extent to whichanalysis can ... toassessment of extant analysis techniques. All authors readand approved the final manuscript.Additional materialAcknowledgementsThis study is funded by UK Medical Research Council and National...
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Báo cáo y học: "A role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectors" ppsx

... is involved in the life-cycle of HIV-1-based vectors. Our finding also supports the hypothesisthat cellular DSB repai r proteins are invo lved in PIR. At the same time, these proteins clearly ... required for efficient integration or PIR. On the other hand, some reduce the efficiency of integration. Finally, some are involved in integration site selection.We have studied the role of the histone ... 7:237http://www.virologyj.com/content/7/1/237Page 5 of 10 RESEA R C H Open AccessA role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectorsJohanna A Smith1, Jennifer Yeung1, Gary D...
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Báo cáo y học: " A case for a CUG-initiated coding sequence overlapping torovirus ORF1a and encoding a novel 30 kDa product" doc

... CentralPage 1 of 6(page number not for citation purposes)Virology JournalOpen AccessShort report A case for a CUG-initiated coding sequence overlapping torovirus ORF 1a and encoding a novel 30 ... Nidovirales, these viruses have a lin-ear positive-sense ssRNA genome encoding a large repli- case polyprotein that is expressed from the genomic RNA(ORF 1a and, via ribosomal frameshifting, an ORF 1a- ORF1b ... report.)Finally, we analysed the alignment with MLOGD - a gene-finding program which was designed specifically for iden-tifying overlapping coding sequences, and which includesexplicit models for sequence...
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Báo cáo y học: "A role for age-related changes in TGFβ signaling in aberrant chondrocyte differentiation and osteoarthritis" ppt

... expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis. J Clin Invest 1996, 97:2011-2019.7. Inada M, Wang Y, Byrne MH, Rahman MU, Miyaura C, Lopez-Otin ... observed by our own group during ageing and OA in murine models [52,53]. Moreover, proteoglycan synthesis is also diff erentially regulated by TGFβ in rabbit and bovine chondrocytes depending on ... pathways are involved in TGFβ signaling (reviewed in [35]). Activation of TGFβ activated kinase 1 occurs independent of ALK5 kinase activity and results in P38 and JNK signaling [36].  at TGFβ activates...
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Báo cáo y học: "A proposal for identifying the low renal uric acid clearance phenotype" pptx

... PL, et al.: A proposal for identifying the low renal uric acid clearance phenotype. Arthritis Research & Therapy 2010, 12:149.Indraratna et al. Arthritis Research & Therapy 2010, 12:149 ... basis for relatively low renal clearance of urate. A renal lesion(s) that reduces the ability of the kidney to clear uric acid, but not creatinine, will manifest as a low FCU relative to ... ±7% from daytime spot urine collections in 12 healthy volunteers [9].Under-excretion or low renal clearance of uric acid Optimally, when searching for the molecular basis of the renal tubular...
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Báo cáo y học: "A role for MCP-1/CCR2 in interstitial lung disease in children" pps

... with interstitial lung disease (ILD) related to ILD disease severity. Percentages of CCR2+CD4+ T cells were analyzed in BALF by flow cytometry. ILD disease sever-ity was scored according ... Corresponding author ChemokinesMCP-1CCR2Bronchoalveolar LavageChildrenInterstitial Lung DiseasesAbstractBackground: Interstitial lung diseases (ILD) are chronic inflammatory disorders leading topulmonary ... worsened in the clinical coursecontinuously (increasing oxygen requirement, increasingdyspnoe) and died from respiratory failure, while onePAP patient remained clinically stable (P18). Thedeceased...
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Báo cáo y học: "A role for prophylactic antibiotics in necrotizing pancreatitis" doc

... pancreaticsuperinfection, but to a lesser extent than prophylactic administration of antibiotics. Parallel to this observation, theyfound that mortality is again significantly lower after prophylactic antibiotics; ... symptoms, andthus at different stages of the pancreatitis, with differentcauses. Some present early with only mild edema, whereasCommentaryA role for prophylactic antibiotics in necrotizing ... antibiotics, prophylactic antibiotics decreased the rate ofpancreatic superinfection. This has been studied before, andsimilar findings were reported by Cinar and colleagues [4].But in a study by Schwarz...
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Báo cáo y học: "A plea for balanced reporting" doc

... References1. Mayer J, Boldt J, Mengistu AM, Röhm KD, Suttner S: Goal-directed intraoperative therapy based on autocalibrated arterial pressure waveform analysis reduces hospital stay in high-risk ... PiCCOplus™ system. Crit Care 2008, 12:R82.doi:10.1186/cc8942Cite this article as: Singer M: A plea for balanced reporting. Critical Care 2010, 14:414.Singer Critical Care 2010, 14:414 http://ccforum.com/content/14/2/414Page ... Singer M: The validity of trans-esophageal Doppler ultrasonography as a measure of cardiac output in critically ill adults. Intensive Care Med 2004, 30:2060-2066.3. Mayer J, Boldt J, Poland...
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Báo cáo y học: "A model for generating circadian rhythm by coupling ultradian oscillators" potx

... number not for citation purposes)Theoretical Biology and Medical ModellingOpen AccessResearchA model for generating circadian rhythm by coupling ultradian oscillatorsVerner Paetkau*1, Roderick ... B, Pye K, Higgins J: Waveform generation by enzymaticoscillators. IEEE Spectrum 1967, 4:79-86.21. Pye EK: Biochemical mechanisms underlying the metabolicoscillations in yeast. Can J Botany 1969, ... detailed computational model for the mammalian circadian clock. Proc Natl Acad SciUSA 2003, 100:7051-6. Epub 2003 May 29 28. Leloup JC, Goldbeter A: A model for circadian rhythms in Dro-sophila...
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Báo cáo y học: " A method for the generation of standardized qualitative dynamical systems of regulatory networks" doc

... of creating the dynamical system in a fully automated way.Nonetheless, after the initial construction and analysis of the resulting system, the modeler may modify the values of the parameters so as to ... logical analysis to find all the steadystates of the system [15]. Generalized logical analysisallows us to find all the steady states of a discrete dynam-ical system by evaluating the functionality ... this paper to present a detailedmathematical analysis of the dynamical system describedby Equation 3. Instead, we present a framework that canhelp to speed up the analysis of the qualitative...
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