... patientswith penetrating trauma.Before performing the actual pharmacokinetic analyses, the baseline level of FVIIa activity was explored, by plotting the activity versus time for the 107 subjects ... wall, and, by directly activating factor X in the absence of tissue factor, this agent promotes the formation of a tight, sta-ble fibrin plug at the site of injury [2,3]. An expanding literaturesuggests ... prothrombin time andactivated partial thromboplastin time are poor indicators of bleeding control in the coagulopathic patient [8]. It is impor-tant, therefore, to establish, from existing clinical...