Báo cáo y học: "Role of CD14 in lung inflammation and infection" pptx
Báo cáo y học: "Role of CD14 in lung inflammation and infection" pptx
... SP-C and SP-D also bind to CD14 at the site which recognizes LPS. Strikingly, binding of SP-A to CD14 enhanced the binding of rough LPS and binding of SP-C to CD14 augmented binding of smooth ... binding of SP-A to CD14 reduced binding of smooth LPS and binding of SP-D to CD14 decreased binding of both smooth and rough LPS. Furthermore, SP-D in uences LPS-induced TNF secretion by ... shedding or cleavage from the surface of monocytes. sCD14 is present in the circulation and other body fl uids and levels of sCD14 in plasma increase during in am-mation and infection. Since interleukin...
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Báo cáo y học: " Role of TNF-α in lung tight junction alteration in mouse model of acute lung inflammation" doc
... Generation of inflammatorycytokines in zymosan-induced pleurisy in rats: TNF inducesIL-6 and cytokine-induced neutrophil chemoattractant(CINC) in vivo. Cytokine 1998, 10(12):956-963.48. Clayburgh ... Thus, a key step in the pathogenesis of acute lung injury may be myosin light chain kinase activationby TNFα, leading to epithelial barrier dysfunction. Thereis extensive literature examining the ... proteins, including ZO-1, junction adhesion molecule 1, occludin, claudin-1, and claudin-4 [27]. The effects of pro-inflammatory cytokineson lung epithelial barrier function were studied usinglung...
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Tài liệu Báo cáo Y học: Role of electrostatics in the interaction between plastocyanin and photosystem I of the cyanobacterium Phormidium laminosum ppt
... between Cyt f and plastocyanin and/ or plasto-cyanin and photosystem I, and subsequently the nature of the interactions in the two lineages (hydrophobic in cyanobacteria, electrostatic in chloroplasts) ... thermodynamic analysis by laser-flash absorptionspectroscopy of photosystem I reduction by plastocyanin and cytochrome c6 in Anabaena PCC 7119, Synechocystis PCC 6803, and spinach. Biochemistry 35, ... protein plastocyanin can bereplaced by cytochrome c6, a redox protein of similar sizebut entirely different folding, in a number of eukaryoticalgae and cyanobacteria including P. laminosum...
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Báo cáo y học: "Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus" pptx
... maintranscription factor regulating Th2 development, GATA-3.Another interesting and recent finding is that the lack of RUNX3 in a mouse model results in eosinophilic airway inflammation. Interestingly, ... previouslyidentified by linkage in sibling pairs, and by thoroughhaplotype analysis narrowed it down to a singlepolymorphism (having excluded the remaining nine thatshowed association out of hundreds studied) ... mobilityassays and transfection experiments with which theycould show the allelic effect of the polymorphisms ongene expression in reporter assays and their effect by co-transfection of RUNX1. In...
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Báo cáo y học: "Role of TRPV3 in immune response to development of dermatitis" doc
... skin lesions and unaffected skin of >90% of patients, and it causes exacerbation of skin inflammation. In contrast, only 5% of normal subjectscarry S. aureus, which is localized mainly in ... wasobserved in the cheek and neck of DS-Nh mice, but not in NC/Nga-Nh mice. Inflammatory cell infiltration wasobserved in the skin of both mice, however hyperkeratosiswas observed only in the skin of ... first sensitization in DS and NC/Nga-Nh,but not in DS-Nh and NC/Nga mice (Fig. 4A and 4B).Inflammatory cell infiltration and hyperkeratosis wereobserved in the skin of DS and NC/Nga-Nh mice...
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Báo cáo y học: "Role of PPAR-δ in the development of zymosaninduced multiple organ failure: an experiment mice study" pot
... primary antibody (anti-nitrotyrosine) in the presence of excess nitrotyrosine (10 mM) to verifythe binding specificity.Terminal deoxynucleotidyl transferase-mediateddUTP-biotin end labeling ... saline administration.Clinical scoring of systemic toxicityClinical severity of systemic toxicity in the mice wasscored during the exper imental period, (7 days) afterzymosan or saline injection, ... creatinine, alanine aminotransferase (ALT),aspartate aminotransferase (AST), bilirubine and alkalinephosphatase were measured by a veterinary clinicallabora tory using standard laboratory techniques....
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Báo cáo y học: "Role of vasopressin in the treatment of anaphylactic shock in a child undergoing surgery for congenital heart disease: a case report" docx
... channels and blunting of theintracytosolic calcium rise sustaining vasoconstriction.Finally, prolonged low systemic hypoperfusion with tis-sue hypoxia and lactic acidosis can maintain all thedescribed ... 500 mcg of epinephrine (by institutional protocol: 25mcg/kg every 5 minutes) were given while oxygen inspir-atory fraction was increased to 1. CPB was instituted in 5minutes in order to improve ... clinical find-ing of bilateral pulmonary wheezing. In order to re-establish hemodynamic stability, volume resuscitationwas started (30 ml/Kg) and two intravenous (iv) boluses of 500 mcg of...
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Báo cáo y học: "Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters" doc
... 0.05).Up-regulation of chymase expression in smoke-exposedlungsTo determine whether chymase is involved in cigarettesmoking-induced pulmonary artery remodeling and PAH, chymase protein and mRNA levels in the ... Murakami K, Miyazaki M: Cloning of the gene and cDNA for hamster chymase 2, and expression of chymase 1, chymase 2 and angiotensin-converting enzyme in theterminal stage of cardiomyopathic hearts. ... the lung, releasing numerous mediatorsthat control the remodeling of pulmonary vessels [3,4].Chymase, a chymo trypsin-like serine protease which ismainly contained in the secretory granules of...
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Báo cáo khoa học: Role of phosphorylation in p53 acetylation and PAb421 epitope recognition in baculoviral and mammalian expressed proteins pdf
... phosphorylated and lysine 382 is constitutively acetylatedFirst, we ascertained the constitutive status of p53modifications at serine 15 (S15) and at lysine 373(K373) and lysine 382 (K382) for recombinant ... recombinant p53 proteins were expressed in Sf9 insect cells by using the baculoviral system and were purified as described previously [15]. Both human and murine p53 proteins were studied and included ... selective acetylation of K373 in p53.K382Ac is part of the PAb421 epitopePhosphorylation and acetylation cascades have manyaspects in common and are linked in the regulation and function of p53 [4,5,22]....
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Báo cáo y học: "Localization of SSeCKS in unmyelinated primary sensory neurons" pptx
... causesextensive diminution in the number of unmyelinated fib-ers (approximately 50% in adults) with minimal impacton the number of thinly myelinated fibers [18-21]. Func-tionally, the unmyelinated C-fibers ... throughout the cytoplasm of sensory neuron somata with an area of increased perinu-clear intensity present in most perikarya (Fig. 4C). Not-withstanding the degree of cytoplasmic labeling, intenseSSeCKS-IR ... articleLocalization of SSeCKS in unmyelinated primary sensory neuronsChristopher P Irmen, Sandra M Siegel and Patrick A Carr*Address: Dept. of Anatomy and Cell Biology, University of North Dakota, Grand Forks,...
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