Báo cáo y học: "Role of chlorhexidine gluconate in ventilator-associated pneumonia prevention strategies in ICU patients: where are we headed" pot

... loredano.pollegioni@uninsubria.itAbbreviations:DAAO,D-amino acid oxidase; RgDAAO, Rhodotorula gracilis D-amino acid oxidase; pkDAAO, pig kidneyD-amino acid oxidase; XO, xanthine oxidase; IP, imino pyruvic acid; EFlox,oxidized ... spatial arrangement in the active site byintroducing a serine. In conclusion, the results obtained with the Y2 38mutant enzymes eliminate this residue as an active site acid/ base catalyst and ... of the Y2 38 side chain in substrate/product exchange to the active site of RgDAAO. A superimposition of the active sites of yeast andmammalian DAAO [2–4] shows that the side chain of Y2 23 of...

... clearly active againstbothL -ascorbate and guaiacol) and has been notedpreviously for the H42E [49,50] and H42A and H42V [51] variants of HRP. These data suggest that the distal histidine residue ... in uen-tial in defining the stability of Compound II. The replacement of the distal histidine residue by alanineor glutamic acid clearly has a profound in uence on the ability of the rAPX enzyme to ... hydrogen-bond-ing structure involving the Ne of His42 and the ferryloxygen. However, although hydrogen-bonding interactions of this kind have been structurally confirmed for the ferrous-oxy...

... hospitalizations eachyear.1Previously characterized as a disease of air-way smooth muscle, asthma is currently definedby the National Heart, Lung, and Blood Instituteas a chronic inflammatory ... University of Saskatchewan,Royal University Hospital, Saskatoon, Saskatchewan; D. D. Marciniuk—Lung Association of SaskatchewanCOPD Professorship; D. W. Cockcroft—Lung Association of Saskatchewan ... asthma.3,4This article reviews the cur-rent literature and updates the reader on the safety,efficacy, and clinical applications of leukotriene modifiers in the treatment of EIB.Role of Leukotrienes in Asthma...

... regarding potential phenotypic and genotypicindicators of response to therapy because one or thecombination of both of these tools will likely be a clue to apatient’s response to therapy.References1. ... therapy, focusing on a potential genetic clue to medication response. Key words: asthma, genetic polymorphisms Our understanding of the pathophysiology and treat-ment of asthma is quickly advancing. ... genetics to aid in choosing the most appropriate therapy. Asclinicians attempting to stay current in the evolving science of asthma, we must continue to follow the very excitingliterature regarding...

... utility of anti-cyclic citrullinated peptide (anti-CCP) antibodies in distinguishingbetween patients with rheumatoid arthritis (RA) and patients with polyarticular involvement associated with chronic hepatitis ... useful in discriminating patients with RA from patients with HCV-associated arthropathy.Keywords: anti-cyclic citrullinated peptide antibodies, hepatitis C virus, rheumatoid arthritis, rheumatoid ... RF = rheumatoid factor.Available online http:/ /arthritis- research.com/content/6/2/R137Research articleRole of anti-cyclic citrullinated peptide antibodies in discriminating patients with rheumatoid...

... cytokineReviewRole of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupusMarta E Alarcón-RiquelmeDepartment of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, ... GATA-3.Another interesting and recent finding is that the lack of RUNX3 in a mouse model results in eosinophilic airwayinflammation. Interestingly, RUNX3 was found to beexpressed in mouse mature ... criticalfunctions in lineage specification and in homeostasis of CD8-lineage T lymphocytes. In addition, RUNX1 and RUNX3 have been found to regulate the expression of CD4 during CD8 lineage commitment...

... CD4+CD25+Treg and detected an accumulation in the inflamed joints, thusexcluding the possibility that the lack of therapeutic activitywas due to the inability of CD4+CD25+Treg to migrate intothe inflamed ... adoptive transfer of preactivated CD4+CD25+Treg can prevent the induction of autoimmunity but cannot ‘cure’ animals with ongoingautoimmunity. Thus it seems that the thresholds to controlinduction ... thatwhen studying CD4+CD25+Treg we have to bear in mindthe compartment (tissue) that Treg are obtained from. Indeed,it is apparent that, to gain significant results, studies onCommentaryRole...

... 1Research articleRole of resistin as a marker of inflammation in systemic lupus erythematosusKatarina Almehed, Helena Forsblad d'Elia, Maria Bokarewa and Hans CarlstenDepartment of Rheumatology ... proinflammatory properties and is abundant in inflammatory diseases (for instance, rheumatoid arthritis (RA)[4] and Crohn disease [5]) and also is associated with inflam-matory markers in several ... properties in humans. Theaim of this study was to determine associations between serumlevels of resistin and markers of inflammation and bone mineraldensity (BMD) in female patients with systemic lupus erythematosus...

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