... hypertension [29,43–45]. In addition toactivation of the renin–angiotensin system, vasopressin,endothelin, and catecholamines are postulated to playimportant roles in the pathophysiology of ... accompanied by evidence of renal disease and by signs of vascular injury to the heart,brain, retina and kidney, and by a rapidly fatal course ending in heart attack, renal failure, or stroke [25]. The ... trigger-ing factor superimposed on pre-existing hypertension. The risks for developing malignant hypertension are related to the severity of the underlying hypertension, and therefore the role of...