... than the other, the future for barbiturates still looksbright. Early combination therapy of barbiturates with hypo-thermia or progesterone, in concert with multimodalityinvasive neuromonitoring, ... Barbituratetherapy for patients with refractory intracranial hypertensionfollowing severe traumatic brain injury: its effects on tissueoxygenation, brain temperature and autoregulation. J ClinNeuroscience ... C, Frei K, El Beltagy M, Cesnulis E, Yonekawa Y, Keller E:Combined therapeutic hypothermia and barbiturate comareduces interleukin-6 in the cerebrospinal fluid after aneurys-mal subarachnoid...