...
Modelling
Open Access
Research
Morphological instability and cancer invasion: a 'splashing water
drop' analogy
Caterina Guiot
1
, Pier P Delsanto
2
and Thomas S Deisboeck*
3
Address:
1
Dip. ... thought
that we propose an analogy with the case of a liquid drop,
which impacts on a solid surface and causes the formation
of a fluid 'crown'. Such inst...
... cancer and how they may point to
new therapeutic approaches.
Signaling pathways and signaling mechanisms
The canonical Wnt/β-catenin pathway is implicated in both
normal development and disease. ... Biology 2007, 8:310
Meeting report
Cell signaling and cancer
Eleni Bazigou* and Charalampos Rallis
†
Addresses: *Lymphatic Development Laboratory and
†
Developmental Genetics Labo...
... absorbance at 315 nm, appeared as a peak at 0.33
M
MDEA and was essentially stable in this buffer at +4 °C
for at least 4 months. The phosphate content of the
phosphopeptide was analysed by the malachite ... phosphatase gene. Astandard
BLAST
search, with AF164795 as the query, was
performed against the nonredundant databases at the NCBI site. In that way, the gene of the human phosphohist...
... of
both actin microfilaments and cytokeratin intermediate
filaments, and with the appearance of a marked cytokeratin
and actin immunoreactivity at the cell junctions [28,42]. The
latter cytoskeleton ... 10
)5
M
forskolin,
an adenylate cyclase activator. A pattern similar to the
thyrotropin stimulation was observed in these experimental
conditions.
Activation of the tyrosine kinase/MAP...
... BL21(DE3)/pNA101; lane 3, recombinant NaoA after
80% ammonium sulfate fraction; lane 4, recombinant NaoA after
Sephadex G75 chromatography; lane 5, purified recombinant NaoA
after DEAE-Sepharose Fast ... DEAE-Sepharose Fast Flow chromatography; lane 6, standard
molecular mass markers (phosphorylase b,97kDa;BSA,66kDa;
ovalbumin, 45 kDa).
Fig. 3. Assay of NaoA activity. (A) Protein extracts from...
... healthy synovial membrane consists of a thin layer of
fibroblast-like synoviocytes (FLSs) and macrophages. These
cells produce glycosaminoglycans such as hyaluronic acid
and lubricating glycoproteins ... staining. (g) Intense staining of a hyperplastic RA synovial lin-
ing cell layer. This staining was typical of most areas of RA synovium
where the lining was hyperplastic. (h) An are...
... 3
Increased intermetatarsal angle
Sesamoid displacement to level of partial disarticulation with the metatarsal head
Possible associated 2
nd
hammertoe and bony adaptation of metatarsal head
Stage ... clas-
sification for degeneration in the 1
st
metatarsophalangeal
joint as described by Regnauld [19] (Table 2).
Sample size, data handling and analysis
Although 122 participants were init...
... recent
weight gain. He had periorbital and facial edema and
moderate pitting edema of both lower extremities and
around the sacral area. Otherwise physical examination
was normal.
Laboratory evaluations ... collected the data and drafted the manuscript. Both BA
and AR revised and approved the final manuscript.
Acknowledgements
We wish to acknowledge the patient and his mother fo...
... National Bureau of Investigation, PO Box 285, 01301 Vantaa, Finland
Email: Nina Lindberg* - nina.lindberg@hus.fi; Taina Laajasalo - taina.laajasalo@helsinki.fi; Matti Holi - matti.holi@hus.fi;
Hanna ... instrumental, dispassionate, and predatory than
that of other offenders [14]. Psychopathy has also been
repeatedly associated with sadistic and sexual violence
[15]. Psychopathic criminal...