... triggers inflam-
matory cascades involving as many as 14 distinct signaling
pathways, including the NF-κB pathway. Interestingly, many
of the genes in these pathways are regulated by the
proteasome ... [8].
Viewpoint
Targeting the ubiquitin proteasome pathway for the treatment of
septic shock in patients
Jan Brun
1,2,3
and Douglas A Gray
1,2
1
Ottawa Health...
... ± 5.9, indicating a
moderate severity of depression. The subjects missed an
average of 10 hours of work in the past 2 weeks owing to
their symptoms, which represented 16% of the time they
were ... productivity subscale
scores.
Figure 1 shows the degree of clinical impairment (defined
as percentage of the sample scoring 2 or higher on the
item, indicating 50% or more...
... scoring.
Variables and point values used for the computation of
the BODE index are shown in table 1. Finally after obtain-
ing the BODE index for all patients, quartiles of the BODE
index were used to ... classification for
explaining these symptoms. Anxious symptoms were
explained by dyspnoea. Depressive symptoms were
explained by both dyspnoea and reduced exercise capac-...
... analysis.
Conclusions In such circumstances, the findings of the present
study should aid future investigators in examining the clinical
usefulness of these markers and determination of cut-off values.
Introduction
Identifying ... the process of aggravation of
brain injury, while brain imaging, physical examination, and
electrophysiology all focus on the consequences...
... 2002
understanding of the function and organization of the
enzyme complex, the analysis of mutant a lleles of the ge nes
involved in the biosynthetic pathway c an certainly provide
valuable information.
In ... addition of Tween 40 [39], i t can be concluded that
the 482 Gly residue is important for the activity of the
enzyme, likely being one of the res...
... otypic analysis (at the p rotein level), the f ew
animals yielding in their milk the a
s1
-CasM variant were
exclusively heterozygous M/F a t the a
s1
-Cas locus. There-
fore, analysis o f their ... secondly impairs
the phosphorylation of Ser64 in the M variant. The
sequence determined is consistent with the molecular mass
measured for the native protein. The phosp...
... elusive.
Relevance of the findings
The question of whether our findings are of any significance
for the understanding of CIJD is justified and needs
answering.
1. Involving microbial infections as a leading ... cells in pathogen-induced chronic inflammatory joint diseases. Any
inflammation will cause the induction of chemokine and cytokine production in several tissue...
... phase
of inflammatory arthritis [27,28]. Since the pro-apoptotic pro-
tein Bid links the extrinsic to the intrinsic pathway, we exam-
ined the affect of inducing experimental inflammatory arthritis
in ... & Therapy Vol 9 No 3 Scatizzi et al.
Page 4 of 10
(page number not for citation purposes)
invasion of leukocytes, proliferation of synoviocytes resulting in
the...
... was involved in the analysis
of data from this study and interpretation and presentation of
results. RY was involved in the interpretation of the data, and
drafting of this article. IO was involved ... adherence to newly-initiated ULDs
was common in gout patients, with only 44% of the study pop-
ulation achieving an MPR > 0.80 in the first year of therapy.
Pre...
... Germany.
2
Interdisciplinary Centre for Clinical Trials (IZKS), University
Medical Centre, Mainz, Germany.
3
Clinic for Psychiatry and Psychotherapy,
Katzenelnbogen, Germany.
4
Clinic for Psychiatry ... discussion of the results.
Psychologists of the in the participating trial sites were
trained in the application of the neuropsychological
tests. At the beginning,...