Báo cáo y học: "C-reactive protein velocity to distinguish febrile bacterial infections from non-bacterial febrile illnesses in the emergency departmen" pptx
Báo cáo y học: "A web tool for finding gene candidates associated with experimentally induced arthritis in the rat" docx
... labelled'OMIMdata'.Selecting keywords and running the application The querying process in this application is divided into foursteps: finding a QTL of interest, displaying the rat/human Available online http:/ /arthritis- research.com/content/7/3/R485R489CD74, ... selecting and ranking keywords, andsearching OMIM text for selected keywords. Finding a QTL of interest The first step in finding candidate genes for a specific QTL isto choose a QTL of interest. ... be associated with a phenotype, but still there areusually many genes within such a region that might be possi-ble candidates. Specifically, when employing QTL analysis in rats, selecting gene...
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Báo cáo y học: "Differential gene expression of bone anabolic factors and trabecular bone architectural changes in the proximal femoral shaft of primary hip osteoarthritis patients" pptx
... 6Research articleDifferential gene expression of bone anabolic factors and trabecular bone architectural changes in the proximal femoral shaft of primary hip osteoarthritis patientsLe-Hoa ... pro-duced by the various bone marrow and bone cell types in the bone microenvironment [42,43]. The role of these growth factors suggests their involvement in the preservation of the bone matrix. The ... is hypothesised to be due to increasedOB biosynthetic activity [18]. The lack of differential gene expression of these anabolic growth factors in our study ismost likely due to the gene expression...
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Báo cáo y học: " Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc" pot
... differences in the cata-bolic pathways between painful and pain-free IVDdegeneration. While this study focused on gene and protein expression profiling, it emphasises the importance of MMP-10 in symptomatic ... to examine the gene and pro-tein expression of MMP-10 in histologically normal human IVD and compare it with that of both non -painful and painful degen-erate IVD. Gene expression of MMP-10 was ... exam-ined and was evident in NP cells and NP cell clusters (Figure2). Expression was predominantly localised intracellularlywithin the cytoplasm of the NP cells. In PM degenerate and surgical degenerate...
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Báo cáo y học: "Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis" ppt
... chemokine receptor < /b> expression < /b> by B cells both in the peripheral blood of < /b> normal donors and < /b> subjectswith RA, and < /b> at the inflammatory site in RA, and < /b> the effects < /b> of< /b> chemokines < /b> on < /b> B cell activation.Methods ... prolifera-tion and < /b> expression < /b> of < /b> cytokines and < /b> activation markers byperipheral blood T cells [36,37], and < /b> that CCL2, CCL5 and< /b> CXCL12 upregulated the expression < /b> of < /b> cytokines and < /b> chem-okines by fibroblast-like ... interaction between CCR5 and < /b> the ligand chemokines < /b> could contribute to the accumulation of < /b> CD27+ B cells in the synovium. Alternatively, because the migration of< /b> CD27+ B cells to all the chemokines...
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Báo cáo y học: "Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model" pptx
... after injection of control small interfering RNA (siRNA) or ADAMTS5 siRNA in the rabbit anular puncture model of disc degeneration. Eight weeks after the control or ADAMTS5 siRNA injections, the ... not for citation purposes)ation, especially in the NP of the rabbit anular puncture model of disc degeneration. ConclusionsA single injection of ADAMTS5 siRNA suppressed disc degeneration in the ... purposes) The intradiscal injection of ADAMTS5 siRNA during the acutephase of disc degeneration after anular puncture in the rabbit delayed the progression of disc degeneration, as assessed byMRI...
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Báo cáo y học: "Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences" ppsx
... framework for perform-ing computational analyses, systematically repeating ana-lyses, capturing all details of performed analyses, and annotating analyses. Using Galaxy Pages, researcherscan communicate ... When a user performs an analysis using Galaxy,it automatically generates metadata for each analysisstep. Galaxy’s metadata includes every piece of informa-tion necessary to track provenance and ... histories. All datasets in a history - initial,intermediate, and final - are vie wable, and the user canrerun any analysis step.While Galaxy’s automatically tracked metadata aresufficient to repeat...
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Báo cáo y học: " Predictors of adherence to antiretroviral therapy among people living with HIV/AIDS in resourcelimited setting of southwest ethiopia" pdf
... rate and predictors of adherence in Ethiopia. Therefore this study determines the magnitude and predictors of adherence to antiretroviral therapy among people living with HIV/AIDS in Southwest ... article as: Tiyou et al.: Predictors of adherence to antiretroviral therapy among people living with HIV/AIDS in resource-limited setting of southwest ethiopia. AIDS Research and Therapy 2010 7:39.Submit ... magnitude and pre-dictors of adherence to antiretroviral therapy among people living with HIV/AIDS in Southwest Ethiopia.MethodsStudy setting The study was conducted in Jimma University Specia-lized...
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Báo cáo y học: "Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium" docx
... CentralPage 1 of 12(page number not for citation purposes)Journal of Circadian RhythmsOpen AccessResearchGlycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link ... the pathophysiology of affective disorders [6]. While there aremany differences in the molecular and genetic details of the circadian machinery in mammals and Drosophila, the basic regulatory principles are ... [21,53].Mathematical modeling of the mammalian circadian oscillator feedback loops has shown that extreme delays(~7 hr) can be achieved by varying the nuclear import rate of the PER/CRY complex, and...
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Báo cáo y học: "Predicting outcome of rethoracotomy for suspected pericardial tamponade following cardio-thoracic surgery in the intensive care unit" ppt
... Girbes1AbstractObjectives: Pericardial tamponade after cardiac surgery is difficult to diagnose, thereby rendering timing of rethoracotomy hard. We aimed at identifying factors predicting the outcome of surgery for suspected ... suspected tamponade after cardio-thoracic surgery, in the intensive care unit (ICU).Methods: Twenty-one consecutive patients undergoing rethoracotomy for suspected pericardial tamponade in the ICU, ... previous rethoracotomy because of surgical bleeding between primary surgery and rethoracotomy for suspected tamponade. Two patientsstarted renal replacement therapy befo re rethoracotomy for suspected...
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Báo cáo y học: " Initiation of bacteriophage T4 DNA replication and replication fork dynamics: a review in the Virology Journal series on bacteriophage T4 and its relatives" pptx
... this article as: Kreuzer and Brister: Initiation of bacte riophage T4 DNA replication and replication fork dynamics: a review in the Virology Journal series on bacteriophage T4 and its relatives. ... Two alternative mechanisms for initiation of DNA replication forks in bacteriophage T4: Priming by RNA polymerase and by recombination. Proceedings of the National Academy of Sciences of the United ... 7:358http://www.virologyj.com/content/7/1/358Page 15 of 16 REVIE W Open Access Initiation of bacteriophage T4 DNA replication and replication fork dynamics: a review in the Virology Journal series on bacteriophage...
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Báo cáo y học: "Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2" pptx
... lung fibrosis develops in the absence of MCP-1 or CCR2To determine whether Aspergillus antigen- induced airway fibrosis develops in the absence of MCP-1 or CCR2, wemeasured lung hydroxyproline ... of 12(page number not for citation purposes)Respiratory ResearchOpen AccessResearchAspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis ... to the reported requirement for CCR2 in the development of bleomycin-induced pulmonary fibrosis, suggests that different cell types and mediators may beoperational in allergen-induced airway fibrosis...
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Báo cáo y học: " Evidence for preferential copackaging of Moloney murine leukemia virus genomic RNAs transcribed in the same chromosomal site" ppt
... genome is mainly formed from RNA moleculessynthesized on the same DNA-provirus. This property of Mo-MuLV may explain why only small subpopulations of gammaretroviruses produce recombinants. In this ... con-text, the differences in the frequencies of recombinationbetween HIV-1 and Mo-MuLV may reflect differences in the ability of these viruses to randomly copackage geneti-cally distinct RNAs. The preferential ... [15], may bea local transport of RNA transcribed in the same locus of chromosome from the nucleus to their destination in the cellular cytoplasm. In the cytoplasm, RNA could bequickly bound by viral...
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Báo cáo y học: "A survey of accessibility and utilisation of chiropractic services for wheelchair-users in the United Kingdom: What are the issues" pps
... as: McKay and Langworthy: A survey of accessibility and utilisation of chiropractic services for wheelchair-users in the United Kingdom: What are the issues? Chiropractic & Manual Therapies ... M: Chiropractic management of myofascial triggerpoints and myofascial pain syndrome: a systematic review of the literature. J Manipulative Physiol Ther 2009, 32:14-24.McKay and Langworthy Chiropractic ... conceived the study and collected and analyzed the data. Both authorsdesigned the study and contributed to and approved the final manuscript.Competing interests The authors declare that they have...
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Báo cáo y học: " Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary" potx
... gamma-aminobutyric acid(GABA). The disinhibition of dopamine-containing neu-rons in the ventral tegmental area (VTA) allows them torelease dopamine in the NAc and (via amygdala) in cer-tain parts of the ... purposes)Theoretical Biology and Medical ModellingOpen AccessReview Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward ... block-ade of naturally required DA release at the NAc.Gabapentin is a gamma-aminobutyric acid (GABA) ana-logue, with GABAmimetic pharmacological properties.Gabapentin is used for the treatment of...
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Báo cáo y học: "Using protein complexes to predict phenotypic effects of gene mutatio" pps
... that of random pairs. To com-pare intersections of predictors to single predictors, theexpected frequency was the greater of the two predictorsalone. To compare intersections of predictors to ... 'phenotype pairs', that is, pairs of geneswhose loss leads to similar phenotypic profiles. If we couldidentify an effective predictor of phenotype pairs, and if thepredictor is sufficiently ... phenotypes to find what types of data are predictive of phenotypes inyeast; we then apply this framework to human diseasephenotypes.Results Protein complexes as predictors of phenotypeSeveral groups...
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