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Báo cáo y học: "ahead at the potential benefits of biotechnology-derived allergen therapeutics" potx

Báo cáo y học:

Báo cáo y học: "Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary"

... Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary Corresponding address: Andrew E. Czeizel Foundation for the Community Control of Hereditary Diseases, 1148 Budapest, ... characteristics of the study population, etc. In Hungary the total prevalence of congenital abnormalities was 66.83 per 1000 informative offspring in the 1980s and within this, the total rate of major ... evaluated, the period of study (only at birth or in early neonatal period or prenatal or the whole infant period are included), the completeness of ascertainment, the diagnostic skill of experts,...
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Báo cáo y học:

Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"

... Germline Gene Therapy An ideal gene transfer system in the context of human germline gene therapy would have the following features: (a) the ability to deliver transgenes in a highly efficient ... applied to humans. The purpose of this paper is to consider the potential for applying the available genetic modification (GM) technologies to the goal of achieving human germline gene therapy. ... International Publisher. All rights reserved Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline Review/Analysis Received: 2004.3.24 Accepted: 2004.5.14...
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Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt

Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt

... the sequences of 1CEV and 1RLA and pasted into the structural alignment. The alignment was then corrected by hand. Since the sequences of the two arginases and agmatinase greately differ in the ... in the case of E. coli agmatinase, of the loop indicated by the letter a.Fig. 5. Scheme of the binuclear manganese cluster and the localization of the side-chains of Asp153 and Asn153 in the ... hydrogen bond is the likely cause of the greately decreased catalytic efficiency of the D153N variant.Keywords: agmatinase; Asp153; site-directed mutagenesis; homology -modelling; E. coli. Agmatinase...
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Tài liệu Báo cáo Y học: Studies on the nonmevalonate pathway of terpene biosynthesis The role of 2C-methyl-D -erythritol 2,4-cyclodiphosphate in plants docx

Tài liệu Báo cáo Y học: Studies on the nonmevalonate pathway of terpene biosynthesis The role of 2C-methyl-D -erythritol 2,4-cyclodiphosphate in plants docx

... J. Biochem. 268) q FEBS 2001 Studies on the nonmevalonate pathway of terpene biosynthesis The role of 2C-methyl-D-erythritol 2,4-cyclodiphosphate in plants Monika Fellermeier1, Maja Raschke1, ... (2000) Studies on the nonmevalonate pathway: conversion of 4-(cytidine 50-diphospho)-2-C-methyl-D-erythritol to its 2-phos-pho derivative by 4-(cytidine 50-diphospho)-2-C-methyl-D-erythri-tol ... were then extracted with ethyl acetate. The aqueous phase was analyzed by HPLC in order to monitor the conversion of [1-3H ]2C-methyl-D- erythritol 4-phosphateinto the corresponding 2,4-cyclodiphosphate. ...
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Báo cáo Y học: Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions pot

Báo cáo Y học: Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions pot

... raises the possibility that any one or acombination of these properties may in uence the binding of apolipoproteins to lipoprotein particles. The capacity to fractionate lipid emulsions into relatively ... apolipoprotein E3 and E4 to emulsions (Eur. J. Biochem. 269) 5941 Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions Matthew A. Perugini1, Peter ... ApoE3 and ApoE4 with EggPtdCho /TO lipid emulsions The binding of apoE3 and apoE4 to lipid particles wasalso assessed using size-fractionated emulsions comprised of egg yolk phosphatidylcholine...
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Báo cáo y học: Advances in the Surgical Management of Chronic Rhinosinusitis

Báo cáo y học: Advances in the Surgical Management of Chronic Rhinosinusitis" pot

... technology has been,theoretically, to increase the safety and com-pleteness of surgery in addition to increasing the confidence of the surgeon. This accounts for the increasing numbers of health ... state of the art in endoscopic sinussurgery includes many recent innovations. Prob-ably the most fundamental change in sinus surgeryhas been the adaptation of rigid endoscopes for use in the ... sur-gical intervention would include the presence of anatomic abnormalities that could predispose the Rhinitis and Sinusitis Advances in the Surgical Management of Chronic RhinosinusitisErin D....
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Báo cáo y học:

Báo cáo y học: "Developments in the clinical understanding of osteoarthritis" docx

... the synovium, in ligaments especially near their insertions, in bone, in muscle, and in the outer third of the meniscus in the knee. In an unusual study in which the lead investigator became the study subject ... providednew insights into how OA may be successfully managed. The symptoms of osteoarthritis: pain andinstability The pain of OA is activity-related, with pain coming ongenerally only when a person ... not the only symptom of OA experienced by patientswith knee and hip OA. They also frequently experience asensation of instability or buckling. The most commonsymptom is one of shifting or instability...
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Báo cáo y học:

Báo cáo y học: "Developments in the clinical understanding of rheumatoid arthritis" ppt

... consequence of the activation of many cell populationsand, ultimately, of the upregulation of proinflammatory cyto-kines [19,20]. By whichever means they themselves becomeactivated, they induce ... activity. The degree of disease activityat the start of a disease-modifying therapy is amajor determinant of the disease activityattainable in treatment.Background and evidence The pivotal clinical ... regardless of their level of improvement.These and other insights mandate a change in clinical trialreporting by requesting the provision of information on cate-gories of disease activity attained in...
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Báo cáo y học:

Báo cáo y học: "Antibodies against the CB10 fragment of type II collagen in rheumatoid arthritis" pdf

... increased the sen-sitivity of detection of antibodies in serum against NCII fromFigure 2Purification of CB peptides of type II collagen (CII)Purification of CB peptides of type II collagen (CII). ... CIICorrelation of antibodies against bovine type II collagen (CII) and human CII. Scatter plot of the levels of IgG antibodies against human CII and bovine CII in sera of patients with rheumatoid arthritis ... when CB10 wasused.Discussion The most significant finding from our study was that in RA the use in an ELISA of fragments of the intact CII molecule,particularly CB10, as antigen markedly increased...
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Báo cáo y học:

Báo cáo y học: " Developments in the scientific understanding of lupus" pot

... responses. Furthermore, immune complexes of ANAscan drive the production of proinflammatory cytokines, inducing the ‘interferon signature’, and intensifying disease. Together, thesefindings point to ... entirety of the immune system. Some of these maybe genetically determined, whereas others arise secondarily in response to events such as infection. Not surprisingly,delineation of these disturbances ... pathways suchas transfection or DNA-binding proteins [11,12]. Within the context of SLE, these findings suggest that moleculesinducing autoimmunity have intrinsic immunologic activity andmay serve...
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Báo cáo y học:

Báo cáo y học: "Developments in the scientific understanding of osteoarthritis" doc

... orinhibitors of inflammatory cytokines.Degeneration of articular cartilage in osteoarthritis:inflammation The role played by inflammatory cytokines and mediatorsproduced by joint tissues in ... hypertrophy and hyperplasia, withan increased number of lining cells, often accompanied byinfiltration of the sublining tissue with scattered foci of lymphocytes [68]. Synovitis is often localized ... latent enzymes isregulated by at least two enzyme inhibitors: tissue inhibitor of metalloproteinases and plasminogen activator inhibitor-1[45]. These enzyme inhibitors are synthesized in increasedamounts...
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Báo cáo y học:

Báo cáo y học: "Ultrasound has the potential to detect degeneration of articular cartilage clinically, even if the information is obtained from an indirect measurement of intrinsic physical characteristics" pdf

... system and the method to detect the early stage of degeneration of human articular cartilage. The signal intensity, considering tissue histology [4] andestimation of the mechanical property of ... charac-teristics of human cartilage in vivo is developed, we believeLetterUltrasound has the potential to detect degeneration of articular cartilage clinically, even if the information is obtained from ... intensity is valuable forclinicians who want to know the mechanism of degeneration of cartilage without performing a tissue biopsy. Until an ultra-sound system that can measure the intrinsic physical...
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Báo cáo y học:

Báo cáo y học: "ahead at the potential benefits of biotechnology-derived allergen therapeutics" potx

... recent attention, the potential benefits of these therapeutics for improvingtherapeutic protocols, patient compliance, and broaderadministration of immunotherapy is equally attractive. At the ... moment, the potential benefits of biotechnology in the field of allergy treatment can only be envisioned, andwhether these benefits will indeed manifest still requiresmany years of research – the ... and allergen- specific immuno-therapy. Allergen- specific immunotherapy (SIT) wasdeveloped in 1911 [4] and is the only treatment thatattends to the root cause, rather than the clinical symp-toms,...
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Báo cáo y học:

Báo cáo y học: "Chiropractic at the crossroads or are we just going around in circles" pps

... emotionality. They selectivelyincorporate scientific findings that support their “majorpremise” while shunning or ignoring scientific findingsincongruent with their way of thinking”.A recent ... In that year Edwin Webb and his colleague scompiled and pub lished the “Report of the Committee ofInquiry into Chiropractic, Osteopathy, Homoeopathy andNaturopathy”, commonly called The Webb ... nothingmore than a legal tact ic used in the Morriubo’scase.”[34], and “B.J. Palmer probably developed his dis-easetheory as a result of the winning strategy used by hisattor ney Thomas Morris...
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Báo cáo y học:

Báo cáo y học: "RNA at the steering wheel" ppsx

... DNA replication, they may become distrib-uted among daughter strands in the same semiconservativeway as newly synthesized DNA [17]. In addition, modifica-tions such as methylated lysine 4 of ... interactionwas further confirmed by the finding that these RNAs alsoco-precipitate with chromatin-bound ASH1, and that the association of ASH1 with the bxd PRE/TRE is abolished byremoving single-stranded ... [13]. Assembly of the DCC presumably takes placeon nascent roX1 or 2 RNAs while they are still tethered to the DNA template on the X chromosome. From these initialnucleation sites, the DCC spreads...
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