... ofjoint debris that may cause a synovitis.Subchondral bone, periostium, synovium, ligaments, and joint capsule are all richly innervated and containnerveendingsthatmaybethesourceofpaininOApatients ... [8,15,36], may result in the mani-festation of pain in other joint tissues. This may be aconsequence of alterations in joint mechanics resulting in structural changes elsewhere and/ or the generation ... may reflect early changes in cartilagestructure that account directly or indirectly for kneepain in both health and disease. The results also suggestthat synovitis and bone remodeling may contribute...