Báo cáo y học: "Inhibition of HIV-1 replication in primary human monocytes by the IκB-αS32/36A repressor of NF-κB" docx

... AIDS.Conclusions In this study we have addressed the role of NF-κB/IκB pro-teins in the replication of HIV-1 in primary human mono-cytes. We show a strong attenuation in the replication of amacrophage-tropic ... amacrophage-tropic HIV-1 strain expressing the IκB-αS32/36A repressor of NF-κB in primary cultures of human monocytes. These results are consistent with previous evi-dence of HIV/SIV inhibition by IκB-αS32/36A ... IκB-αS32/36A in PBMCsand in macaques [16,17]. In addition, these findingsAttenuated replication of NL(AD8 )IκB-αS32/36A in primary human monocytesFigure 3Attenuated replication of NL(AD8 )IκB-αS32/36A in...

Báo cáo y học: "Treating patients with fibromyalgia in primary care settings under routine medical practice: a claim database cost and burden of illness study" docx

... as assessed by the Brief Pain Inventory (BPI)Annual mean costs of fibromyalgia patients according to severity of pain as assessed by the Brief Pain Inventory (BPI). The range of the BPI is from ... costs of fibromyalgia patients according to severity of pain as assessed by the Brief Pain Inventory (BPI)Annual mean costs of fibromyalgia patients according to severity of pain as assessed by the ... costs and the degree of interference in daily activities caused by the pain asmeasured by the 11-point numeric rating scale. Finally, whenpatients were classified according to item 5 of the EQ-5Dquestionnaire...

Báo cáo y học: "Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells" potx

... inhibitor diet therapy in a murinemodel of systemic lupus erythematosus. Arthritis Rheum2007, 56:4132-4141.7. Yang P, Zhang Y, Ping L, Gao XM: Apoptosis of murine lupus Tcells induced by the selective ... steroid-sparing drugs for lupus therapy.Indeed, intermittent therapy with low doses of the COX-2inhibitor celecoxib (Celebrex) has beneficial effects in murinemodels of lupus [6,7], and preliminary ... some systemic effects of diets rich in api-genin are detectable [44]. Bioavailability has been improved in the case of other drugs by the pharmaceutical industry, andsimilar attempts are being...

Báo cáo y học: "Treating postnatal depressive symptoms in primary care: a randomised controlled trial of GP management, with and without adjunctive counselling" ppt

... morbidity or improving outcomes [16]. The present study similarly sought to examine the effectiveness of counselling informed by the principles of CBT and delivered by primary care practitioners ... other RCTs of psychological interventionsfor PND in primary care settings [11]). A total of 46GPs received the training (some had more than one of their patients in the study).Twenty two nurses ... random) .The interventions were CBT-based orcounselling-based (psychodynamic therapy was also eval-uated in one study), and the nu rses were trained in theseapproaches. With the exception of one...

Báo cáo y học: " Rigid fibrescope Bonfils: use in simulated difficult airway by novices" pptx

... in cases of difficult airwaymanagement without extensive training and clinical rou-tine. As the success of emergency airway management isstrongly influenced by the level of training and expertisewith ... probability < 0.05.ResultsNormal airwayAll physicians successfully intubated the trachea using the Macintosh laryngoscope in the normal airway situation. In contrast, 82% (25/30) of intubation ... monitor system allows an eas-ier and less time consuming endotracheal intubation,especially in untrained physicians. However, endotra-cheal intubation was performed in this study by using the eyepiece...

Báo cáo y học: "Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal" pot

... were then cloned into the BsrGI sites of the linearized pYES2yEGFP, resulting in the formation of pYES2yEGFP -IN (GFP -IN) , pYES2yEGFP-152 -IN (GFP-152 -IN) and pYES2yEGFP-180 -IN (GFP-180 -IN) . ... interaction in HIV-infected cellsFigure 7NLS -IN- Pen inhibits IN nuclear import by the dissociation of IN- importin α interaction in HIV-infected cells. (A) H9 lymphocytes were infected by wild-type HIV-1, ... focused on the nuclear import of IN protein using yeast and mammalianBinding of IN to importin α as estimated by an ELISA-based systemFigure 6Binding of IN to importin α as estimated by an ELISA-based...

Báo cáo y học: " Inhibition of HIV-1 replication by small interfering RNAs directed against Glioma Pathogenesis Related Protein (GliPR) expression" potx

... lls infecte dwith HIV-1 by a differential display screen [9]. There-fore, we were interested in delineating the role of GliPRfor HIV-1 replication. GliPR was identified originally in human ... the T cell line resultsare in line with the data in P4-CCR5 cells.Furthermore, the effect on HIV-1 replication wasexamined by the integrated HIV-1- LTR-driven reportervector expressing b-galactosidase ... GliPR by HIV-1 and the early significant inhibition of HIV-1 replication mediated by knockdown of GliPR reveal GliPR as an important HIV-1 dependency factor (HDF), which may be exploited forHIV-1...

Báo cáo y học: "Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex" potx

... [9,10]. The kinase active, free formcontains Cdk9 and one of several cyclin regulatory subu-nits, cyclin T1, cyclin T2a, cyclin T2b or cyclin K, with cyc-lin T1 being the predominantly associated ... for inhibition of HIVInhibition of HIV-1 infectivity by non-cytotoxic concentra-tions of the P-TEFb inhibitors DRB, seliciclib and flavopiridolFigure 4Inhibition of HIV-1 infectivity by non-cytotoxic ... replication in infected individuals.ResultsInhibition of Cdk9 kinase activity by P-TEFb inhibitorsTo determine the effectiveness of preparations of the cyc-lin dependent kinase inhibitors,...

Báo cáo y học: "Inhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptides" pptx

... purposes) The inhibitory effect against the lentiviral vector wasdetermined by preincubation of the vector with human cathelicidin LL37, recombinant human β-Defensin-2,porcine PG-1, fungal Plectasin ... increasing the selec-tivity of HDPs for early steps in the viral replication cycleseems to be necessary for further development of the human cathelicidin LL37 and the porcine Protegrin-1 asantiviral ... gp120 of HIV-1 andinhibition of HIV entry has also been identified as the mechanism of inhibition of HIV infection by thetadefensins [38]. Due to their inhibitory effect on HIV-1 replication...

Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt

... maintenance of tumor cell growth[3]. The ﬁnding that the ERK signaling pathway is involved in tumor cell migration and invasion [4,5], as well as in tubular formation induced by insulin in human endothelialcells ... NAMI-A-mediated inhibition of ERK1/2 phosphorylation may be lying upstream of ERK1/2.Using a serine/threonine kinase SPA assay kit, the capability of NAMI-A to affect the ERK1/2 phosphoryla-tion activity ... by NAMI-A may be a part of the molecularmechanism by which this drug exerts its antimetastaticactivity in vivo. Such a view may be further inferred by the following observations. The NAMI-induced...

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