Báo cáo y học: " Alterations in the expression of DEAD-box and other RNA binding proteins during HIV-1 replication" potx

... multiplicity of infection inocula.Figure 1 shows the expression patterns for genes encodingDEAD box proteins, and other genes encoding RNA heli-cases and RNA binding proteins, as assigned by the ... latency and during latency and early lytic replication. Panel D shows the expression profile of genes encoding ABC transporter proteins. The bottom of the figure shows a scale indicating the color ... regulated during this period, including the methylated mRNA cap binding proteins EIF4G1 [27] and NCBP1 (CBP80) [28], whichfunction in translation initiation and may also beinvolved in mediating nuclear...

Báo cáo y học: "Changes in the expression of NO synthase isoforms after ozone: the effects of allergen exposure" doc

... the enzyme NO synthase: two constitutive NO synthases(cNOS) are involved in the physiological regulation of air-way function, and an inducible form of the enzyme(iNOS) is involved in inflammatory ... alterations in the timing of breathing, as well as prolongation of the expiratory time.Furthermore, airway constriction increases the thoracicflow asynchronously with the nasal flow, resulting in anincrease ... is caused by volume and resultantpressure changes in the main chamber during the respira-tory cycle of the animal. A pneumotachograph withdefined resistance in the wall of the main chamber...

Báo cáo y học: "Alterations in the complement cascade in post-traumatic stress disorder" potx

... of the complement alternative pathway and overactivation of the terminal pathway.Conclusions: The results obtained provide further evidence on the involvement of the inflammatory component in ... volunteers were involved in this study. In the blood serum of the study subjects hemolyticactivities of the classical and alternative complement pathways, as well as the activities of the individualcomplement ... terminal pathway;2. Alterations in the activities of the classical and the alternative complement pathways in PTSD are notinterdependent;3. The alternative pathway in PTSD is suppressed onthe...

Báo cáo y học: "Alterations in the muscle-to-capillary interface in patients with different degrees of chronic obstructive pulmonary disease" pps

... these findings and show thatCFPE-index is also correlated to the degree of airflowobstruction as determined by spirometry and to exercisecapacity determined by the 6-min walking test. In the context ... design of the study as well aspatient recruitment. KP-A performed the muscle biopsy sampling and partici-pated in the design and coordination of the study. FK conceived the study and helped on the ... glycolytic type IIafibres are mainly recruited during high speed, high-forcegenerating muscle activities. As walking is considered alow intensity activity the 6-min walking test recruits typeI...

báo cáo hóa học:" Decrease in the expression of the type 1 PTH/PTHrP receptor (PTH1R) on chondrocytes in animals with osteoarthritis" potx

... histologicchanges of the cartilage and bone tissue according to the Mankin scale [16]. The Mankin score included assess-ments of the structure, cellularity, Safranin stainability, and integrity of the tidemark. ... After opening the knee joint, OA was macroscopically graded and hyaline cartilage of the load-bearing area was evaluated histologically according to the Mankin scale and by immunostaining for ... a single dose of anesthesia. The knee jointswere opened using a medial paramedian skin incision of 3cm in length and a medial parapatellar incision of the capsule. In animals of group 1, the...

Báo cáo y học: "Hypoxia in the pathogenesis of systemic sclerosis" ppt

... procollagenprolyl hydroxylases (P4HA1 and P4HA2), lysyl oxidase (LOX) and lysyl hydroxylases (procollagen lysyl hydroxylase and procollagen lysyl hydroxylase 2). Similar links betweenhypoxia and fibrosis ... However, the role played by other members of the HIF family in the pathogenesis of SSchas not yet been investigated in detail.Insufficient response to hypoxia: dysregulation of angiogenesis in systemic ... an acetyltransferase, binds directly to the ODDD of HIF-1α in the cytoplasm and acetylates a singlelysine residue at position 532. Acetylation of this specificlysine residue favours the interaction...

Báo cáo y học: " Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets" pps

... surprising considering the components of the ACR criteria. One of the criteria is the presence of erosions on the radiographs of hands and wrists. In the early phases of RA only 13% of the patients ... Additionally, erosions often initiallypresent in the small joints of the feet, and appear in the smalljoints of the hands at a later point in the disease course [6].Also, rheumatoid nodules are very ... areconvincingly replicated in independent cohorts. Moreover,although a recent twin study indicated that genetic factorsplay a role in determining the severity of RA [46], the heritability of the...

Báo cáo y học: " Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study" pdf

... perpetuate the chronic process by their markedincreased accumulation in the synovial lining of the inflamedjoint and their ability to produce numerous proinflammatorycytokines and growth and angiogenic ... contributors to the pathogenesis of RA. MCsmay be considered the immunological sentinel of the syn-ovium, acting immediately in the event of joint trauma by liber-ating an array of proinflammatory mediators. ... MCs, and c-KIT is intrinsically linked withSCF; hence, inhibition of the c-KIT pathway affects RA. Smallmolecules capable of blocking ATP binding and TK activity of c-KIT, both selectively and...

Báo cáo y học: "Cytokines in the colon of a patient with Behçet’s disease" ppt

... Research & Therapy, in whichthey describe cytokine patterns of inflamed joints frompatients with Behçet’s disease (BD). The authors show thatneutrophils and T lymphocytes are involved in a Th1-skewedinflammatory ... significantly and IVIGs were terminated while TNF blockage was continued.Cytokines were evaluated in the resected colon by analyzingmRNA expression levels of cytokine genes as previouslydescribed ... microscopically. The mRNA expression of cytokines in diseased colon is presen-ted relative to that of healthy colon and can be seen asa reflection of intramural cytokines (Figure 1). Like Cañeteand...

Báo cáo y học: "Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes." potx

... species, and that only one of the two copies of the bystander gene is still in synteny with the corresponding copy of the target gene in the fish genome. The code captures the relationship of the bystander ... to the first, a GRB is definedphysically by the extent of long-range regulatory elementsaround its target gene. Therefore, the combined synteny of HCNEs and the intertwined genes defines a minimal ... distinguish-ing between the target gene(s) and the bystander genes in aGRB, there is a growing list of features of target genes that setthem apart from bystander genes and other genes in the http://genomebiology.com/2009/10/8/R86...

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