... AccessReview Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably?Rodney S Russell1,2, Chen Liang1,3 and Mark A Wainberg*1,2,3Address: 1McGill AIDS Centre, Lady Davis Institute, ... discovery that the causative agent of AIDS wasalso a retrovirus, inhibition of RNA dimerization was pro-posed as a possible therapy for HIV, and HIV-1 RNA dimerization became an intensely studied ... a prerequisite for genome encapsidation, a notion that has been debated for many years. In thisarticle, we review retroviral RNA dimerization and packaging, highlighting the research that hasattempted...