... mito-
chondrion and the Bcl-family of proteins in the induction of
lymphocyte apoptosis during sepsis. Overexpression of Bcl-2
or adoptive transfer of Bcl-2 overexpressing lymphocytes in
murine models ... shar-
ing only domains 1–3 [17]; and the group of BH3-only
proteins, which contain only domain 3 and function as sensors
and transducers of apoptotic signals (eg,...
... infection of epithelial cells induce the expression
of several proinflammatory cytokines and chemokines
both in vitro and in vivo , which could be linked to the
consequence of fatal hypercytokinemia ... mechanism of cytokine/chemokine bio-
synthesis may be interrupted by the viral components.
Cytokines and chemokines generally function in an
autocrine (on the pro ducing...
... be
phosphorylated by ERK to increase its DNA binding
activity [27], it will be interesting to test whether the
ERK activity could be induced by NBS1 overexpression,
leading to the phosphorylation of ... Taipei
County, 220, Taiwan.
2
Institutes of Biochemistry and Molecular Biology,
National Yang-Ming University, Taipei 112, Taiwan.
3
Institute of Bioinformatics
and Systems Biology,...
... is involved in host inflammatory
responses and is synthesized by many different cell types,
including fibroblasts and epithelial cells. Expression of IL-
8 may inhibit the antiviral activity of ... is
pro-inflammatory in specific cells. Further dissection of
the pathways involved in HCV core-mediated signaling
may provide a clearer understanding of the pathogenesis
of pu...
... Westburn Lane, University of St Andrews, Fife, KY16 9TS, UK
2
Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Science, 46 Cleveland St, University College London, London, ... acid to tyrosine at position 116)
was performed using Stratagene Quickchange (Stratagene,
La Jolla, USA) methodology. Transfectants were selected and
maintained in 1 mg/ml G418...
... problem in primary care [45].
Conversely, inquiry regarding cough in patients with
mental health problems may also be crucial in identifying
reversible morbidity in this group. In one study, successful
treatment ... particularly depression, and significantly
reduced quality of life, indicates cough is a major contrib-
utor to morbidity in the community. The reduction in
qual...
... these
effects are generally displayed by nonsteroidal anti-
in ammatory d rugs (NSAIDs), w e examined the effects of
a cyclooxygenase inhibitor, indomethacin, and a lipoxyg-
enase inhibitor, nordihydroguaiaretic ... caused by an expanded poly-
glutamine tract in a cellular model of polyglutamine dis-
ease. These findings suggest that NSAIDs generally induce
the e xpression of hsps in...
... The resulting ratios of RC/
transgene vector are indicated. CD40L and IL-2 transgene expression analyses were performed two days p.i. by flow cytometry and ELISA,
respectively. Asterisks indicate ... supernates of HeLa c ells, as opposed
to undetectable CD40L expression in these cells, is
most likely explained by the difference of sensitivity
and/ or dynamic range of the as...
... issociated single cells
after u sually 5 days and reach sizes of 5 mm; they contain
proliferating cells and their interior is surrounded by an
almost complete single-cellular layer of epithelial-like ... to strongly
inhibit protein synthesis i n s ponge cells [22], it is concluded
that the (2–5)A synthetase system is involved in defense
against microorganisms, very likely by inhib...
... IL-
10 and M-CSF signals may be involved in the high expression
of TNF receptor in lining macrophages in the inflamed ST of
RA.
Microarray analysis of IL-10-induced gene expression in
RA monocytes
To ... tissue, including the
lining layer and lymphocyte infiltrates. Colocalisation analysis
revealed that the CD68
+
synovial lining layer contained a large
number of c...