... cell death and DNA fragmentation. Survival assays(MTT-based assay) and DNA fragmentation ELISAs were performedas described in Materials and methods, and the d ata are presented asmeans SD ... 385±401.10. Sato, A ., K oyama, S., Yamada, H., Suzuki, S., T amura, K.,Kobayashi, M., Niwa, M., Yasuda, T., Kyogoku, Y. & Kobay-ashi, Y. (2000) Three-dimensional solution structure of a disul®debond ... apoptosis have not traditionallybeen used to analyse biological activity of analogues.However, comparisons of receptor binding and biologicalactivities, such as protein and DNA synthesis and...