... 6:20.44. Yamamoto N, Tanaka C, Wu Y, Chang MO, Inagaki Y, Saito Y, Naito T,Ogasawara H, Sekigawa I, Hayashida Y: Analysis of humanimmunodeficiency virus type 1 integration by using a specific, ... has another reason aside from the lack of LEDGF/p75. It is also due to inhibition of the viral integrase (IN) enzymatic activity by an early expressedviral Rev protein. The formation of an inhibitory ... indicated that this is due to the fact that the large majority of the viral IN molecules, which catalyze the integration reaction, are inactive as a result of theirFigure 4 INr peptides stimulate...