Báo cáo y học: "Estimation of the cost of treatment by chemotherapy for early breast cancer in Morocco" ppsx
Báo cáo y học: "Estimation of the cost of treatment by chemotherapy for early breast cancer in Morocco" ppsx
... evaluate the cost of individual treatment, weneed the following information: 1) the unit price of dif-ferent drugs used in adjuvant treatment of breast cancer, 2) the kind of therapy according to the ... Estimation of the incidence of curative breast cancer in MoroccoWe used a second database to estimate the incidence of breast cancer in Morocco by extrapolating the rate of breast cancer provided by the ... treatment, the cost of a therapy withtrastuzumab is 8.4 times the cost of a chemotherapy with anthracycline and taxane, and nearly 60 times the cost of a chemotherapy based on anthracyclinealone.Table...
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Báo cáo y học: " Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice
... and the gastrointestinal tissues from the cytotoxicity of CY in mice. We also profiled the changes of the expression of growth factors in gastric tissues in response to the damage by CY and ... of CY in cancer patients in which the herb could be used together with the cytotoxic agent in cancer therapeutic regimen. In the present study, we investigated whether AP could protect the ... toxicity of CY on bone marrow by measuring WBC number in the peripheral blood. Twenty microliters of blood was mixed with 380μl of Randolph’s solution. WBC counting was then performed by using...
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Báo cáo Y học: Ferritin from the spleen of the Antarctic teleost Trematomus bernacchii is an M-type homopolymer doc
... erritins. Thus,H c hains predominate in spleen and liver at variance withthepresenceofL chainsinthesameorgansofmammals[6].Interestingly, a study of cold-inducible gene expression of rainbow ... indicated for the N-terminalpeptide MDSQVR a value of m/z 777, which points t o the presence of acetylme thionine. This r esidue is commonlyfound in the N-terminus of eukaryotic proteins togetherwith ... rotein Analysis System) proteomics s erver of the Swiss Institute of Bioinformatics (SIB).Iron incorporation experimentsIron incorporation experiments were performed by addition of a f reshly prepared...
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Báo cáo y học: "What determines the evolution of early undifferentiated arthritis and rheumatoid arthritis? An update from the Norfolk Arthritis Register" ppt
... [24].Non-Hodgkin’s lymphomaAlthough there was no evidence of any overall increased risk of cancer in the early years of IP and RA in NOAR, there wasa definite increased risk of developing non-Hodgkin’slymphoma ... evidence of anyinflammatory activity in their joints while they are off treatment. Persistence is the opposite of remission. There are problems in the literature regarding the definition of remission ... diseaseseverity. Those patients whose disease starts badly tend tocontinue to do badly. We have shown the benefits of startingdisease-modifying therapy early in the course of the disease. The fact...
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Báo cáo y học: "Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling" ppsx
... effects of diac-erein/rhein on the synthesis of major proteases involved in bone remodelling/resorption, namely MMP-13 and cathepsinK. Moreover, we sought to gain new insight into the effects of the ... and cathepsin KSince MMP-13 and cathepsin K are produced by the murinecell line Raw 264.7, proteins not recognized by the commer-cially available ELISAs, determinations were performed usingactivity ... μg/mL).Effect of diacerein/rhein on intracellular signalling pathwaysTo gain insight into the mechanisms of these drugs on the OAsubchondral bone osteoblasts, we further studied the effect of the therapeutic...
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Báo cáo y học: "RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro" pps
... thatapoptosis of MCF-7 breast cancer cells induced by the BPrisedronate involved increased levels of Bim [50]. Upregula-tion of Mcl-1 (and therefore antagonism of Bim) by RANKL istherefore a likely mechanism ... survival.Mcl-1 inhibits activation of the mitochondrial pathway of apop-tosis by interacting with pro-apoptotic Bcl-2 family proteinssuch as Bak and Bim, thereby preventing the increased mito-chondrial ... ALN in vitro. This protective effect of RANKL is likelyto be mediated at least in part by an increase in the level of the anti-apoptotic protein Mcl-1. The ability of RANKL, togetherwith other...
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Báo cáo y học: "Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes." potx
... that only one of the two copies of the bystander gene is still in synteny with the corresponding copy of the target gene in the fish genome. The code captures the relationship of the bystander ... as measured by branch length in the gene tree, anddefined the closer of the two genes in the other teleost as the ortholog. The bystander gene was then placed at the lowerlevel of the same branch ... break somewhere in the middle of the zebrafish BCAS3 ortholog in the tbx2a locus, leading to the removal of the 5' part of the gene and that portion of the intragenic HCNE array. By this rearrangement,...
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Báo cáo y học: "GWASs and the age of human as the model organism for autoimmune genetic research" doc
... matory disease that destroys free moving joints. T1D is a form of diabetes that results from the destruc-tion of insulin-producing beta cells of the pancreas. IBD is a group of in ammatory conditions ... conditions of the colon and small intestine; the two major types are Crohn’s disease and ulcerative colitis. In SLE, the immune system attacks a wide variety of organs, including the heart, joints, ... causal gene. The rst is to perform dense genotyping to identify the set of common SNPs that yield the strongest signal of association, followed by hypothesis-driven functional studies. The second...
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Báo cáo y học: "Genomics through the lens of next-generation sequencing" potx
... Mike Snyder (Stanford University, Stanford, USA) used chromatin immunoprecipitation followed by DNA sequencing (ChIP-seq) to examine the variability in transcription factor binding among individuals ... Labora tory, Berkeley, USA) continued these themes in a talk that highlighted the limitations of using comparative genomics to identify enhancers. By performing ChIP-seq with the enhancer-associated ... ecologically differentiated by a set of niche-specific genes.Finally, James Taylor (Emory University, Atlanta, USA) offered an integrated vision of how we might aim to do science in the age of next-generation...
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Báo cáo y học: "What does the marriage of Open Access with online publication bring" docx
... and clinicians abreast of the latestresearch on HIV-1. AIDS Research and Therapy will be par-ticularly interested in publishing articles on novel anddeveloping treatment strategies for AIDS, ... improving the quality of the journal. Consequently, the Editorial Board of the journal will constantly seek new ideas to improve the journal to serve as an excellent resource in AIDS researchand therapy ... therapy to the scientific community.Rapid dissemination of science is crucial for the progressand survival of human kind. Let the wheel of communica-tion roll at the fastest pace and to the...
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