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Bóa cáo y học: "Could CT screening for lung cancer ever be cost effective in the United Kingdom" pot

Bóa cáo y học:

Bóa cáo y học: "Could CT screening for lung cancer ever be cost effective in the United Kingdom" pot

... plausible screening scenario with an ICER below the NICE thresh-old. Therefore, the answer to the question – could CT screening for lung cancer ever be cost- effective in the UK?– must be squarely in ... Second,attending for screening inevitably entails the incurring oftime and travel costs on the part of those being invited.These costs can be sizeable: in a trial of clinic-based screening for colorectal cancer, ... number not for citation purposes) Cost Effectiveness and Resource AllocationOpen AccessResearchCould CT screening for lung cancer ever be cost effective in the United Kingdom?David K WhynesAddress:...
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Báo cáo y học: "Burden of disease and costs of aneurysmal subarachnoid haemorrhage (aSAH) in the United Kingdom" ppsx

... by gender was defined. The number of persons at the beginning of each intervalwas calculated by subtracting from the number of people in the previous interval the number of deaths occurring in ... person-years were esti-mated as the number of person-years in an interval plusany previous year. These were then divided by the num-ber beginning in each interval to estimate life expectancy in ... workingage carers, the number of hours spent caring and the number of informal carers in each age group. They valuedinformal care costs using wage rates for the employedcarers (economically active)...
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Báo cáo y học: "Central fatigue and nycthemeral change of serum tryptophan and serotonin in the athletic horse" potx

... neutralamino acids and serotonin in the horse: a preliminary study. In Proceedings of the symposium "Biological rhythms in livestock" Messina,Italy:95-99. 14 October 20022. Borjigin J, ... alterbrain neurochemistry, especially that involving carbohy-drates and serotonin [5,8,19]. It has been hypothesizedthat tryptophan infusion may increase fTrp (free-tryp-tophan) and the fTrp-to-BCAA ... and 5-hydroxyindoleacetic acid (5-HIAA) wereobserved in rats, suggesting that the nycthemeral factorsaffecting serotonin metabolism can be different amongbrain areas [16].It has long been known...
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Báo cáo y học: "Pre- and post-bronchodilator lung function as predictors of mortality in the Lung Health Study" pot

... NC). Our primary outcome of interest in the survival models was mortality, and the main predictor of interest in our analysis was COPD severity defined by stage of lung function, both pre- ... participated in the design of the study, drafting the manuscript, and interpreting the results. ASB assisted in acquiring the data, drafting the manuscript, and interpreting the results. All ... bronchodilator lung function data from the Lung Health Study to determine whether these measures differ in their ability to predict mortality. Methods: We limited our analysis to subjects who were...
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Báo cáo y học: "Serologic and PCR testing of persons with chronic fatigue syndrome in the United States shows no association with xenotropic or polytropic murine leukemia virus-related viruses" pot

... 7precluding the possibility of low level viral infection in blood or in other reservoirs. Given the recent findingthat an XMRV antibody test, using even a single XMRVprotein, had 100% sensitivity for ... 85°C, 5 min to stop the reaction.Nested PCR was then performed as for DNA testing using the Expand High Fidelity PCR System (Roche) and AmpliTaq (AppliedBiosystems) for the primary and nested ... peroxidase conjuga ted protein G instead of proteinA/G [9]. Seroreactivity was defined by reactivity to viralEnv and/or Gag proteins of the expected size as seen in the positive control antisera...
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Báo cáo y học: "Pro/con debate: Should antimicrobial stewardship programs be adopted universally in the intensive care unit" potx

... escalating, with systemic antibiotics being the single most costly drug class over the past decade in non-federal hospitals in the United States. In 2007, systemic antibiotics accounted for 11.2% ... teaching hospital reported a 37% reduction in the number of days of unnecessary antibiotics use by decreasing the duration of treatment and by reducing new starts [25]. In another study, antimicrobial ... patterns replacing the old ones. A study documenting the introduction of new guidelines that restricted cephalo-sporin use was primarily aimed at reducing the incidence of cephalosporin-resistant...
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Báo cáo y học: "Could chiropractors screen for adverse drug events in the community" potx

... improving the integration andcoordination of care for patients with suspected adversedrug reactions in the community. Prescribing clinicians,nonprescribing clinicians, and informed others ... drugsafety initiatives by identifying potential adverse drug events in their chiropractic patients, and by bringingsuspected adverse drug events to the attention of the prescribing clinicians.Methods: ... corticosteroid-induced psychosis [33-37].Psychiatric symptoms may develop at any time during the course of corticosteroid therapy, or even after cessa-tion of therapy, and may manifest as memory...
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Báo cáo Y học: An alternative model for photosystem II/light harvesting complex II in grana membranes based on cryo-electron microscopy studies pptx

Báo cáo Y học: An alternative model for photosystem II/light harvesting complex II in grana membranes based on cryo-electron microscopy studies pptx

... set for the PSII/LHCII crystals. When this is complete, the data shouldreveal much more concerning the nature of the contacts in the crystals and offer further insight into the interplaybetween ... reasonably evenly sampled by the data. Neverthe-less, the physical restriction imposed by the specimen holder in the microscope means that there is a Ômissing coneÕ of datacorresponding to tilts beyond ... photosynthesis, and suggests potentiallinks between c yanobacterial and plant photosystem II lightharvesting systems.Keywords: photosynthesis, structure, photosystem II, light-harvesting, electron...
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Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt

Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt

... nuclearextracts were incubated with avidin–agarose beads (Sigma)at 4 °C for 30 min to eliminate materials in the extracts thatbind nonspecifically to the beads. After removing the beadsby filtration, ... of the biotinylated MREa probe. In addition, 50 pmolMREaMut1 oligonucleotides were added to the bindingreaction as a substitute for poly(dI-dC) for the competitionassay. The binding reaction ... apolyvinylidene difluoride membrane, and the individualproteins were subjected to N-terminal sequencing. The N-terminus of the 70-kDa protein was blocked by modi-fication. Therefore, the protein...
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Báo cáo Y học: A critical motif for oligomerization and chaperone activity of bacterial a-heat shock proteins pot

Báo cáo Y học: A critical motif for oligomerization and chaperone activity of bacterial a-heat shock proteins pot

... well as spinlabeling studies with aA-crystallin and Hsp27 [45] indicatethat the dimeric building block of many a-Hsp proteins isformed by interacting bstrands in the a-crystallin domain.Although ... encoding the isolated a-crystallin domain or the a-crystallin domainincluding either the N-terminal region or the C-terminalextension were constructed in a similar manner. Mutationsleading ... doi:10.1046/j.1432-1033.2002.03049.xconsisting of the a-crystallin domain alone [HspH(a)], the a-crystallin domain plus the N-terminal region [HspH(Na)],or the a-crystallin domain followed by the C-terminalextension [HspH(aC)],...
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