... arginine methylation of the N-termi-
nal portion of the ARM of Rev by PRMT6. This methyl-
transferase reduced RRE binding and diminished export
of viral RNA to the cytoplasm in cell-based assays. Co-
immunoprecipitation ... methyltransferase activity, but seems to
be caused by a yet undefined activity of PRMT6, which
may be linked to the proteasome pathway, as prev...
... 21400, Diyarbakir, Turkey,
2
Department of Radiology, Diyarbakir Education and Research Hospital, Op Dr
Seref Inaloz Caddesi, 21400, Diyarbakir, Turkey and
3
Department of Pathology, Diyarbakir ... rare case of renal
oncocytoma associated with erythrocytosis: case report. BMC Urol
2006, 6:26.
4. Demos TC, Malone AJ Jr: Computed tomography of a giant renal
oncocytoma. J Comp...
... of neoplastic lymphocytes may result in a loss of
coherence between basal keratinocytes and basal lamina
[7] or the cohesion of keratinocytes m ay be affected by
the release of lymphokines by ... lymphadenopathy nor
organomegaly were present. Histological examination of
these lesions revealed subcorneal and intra-epidermal
bullae accompanied by infiltra tes of atypica l lympho...
... transdominant Rev blocks
the export of Rev from the nucleus to the cytoplasm. Virology
1995, 213:439-449.
5. Meyer BE, Malim MH: The HIV-1 Rev trans-activator shuttles
between the nucleus and the cytoplasm. ... (the 4 Kb singly spliced and 2
Kb fully spliced RNAs) [1]. While the fully spliced RNAs
are exported to the cytoplasm, where they are translated
into the regulatory...
... high affinity (step 4). Binding of K
+
leads to dephosphorylation of the enzyme
andtotheocclusionoftwoK
+
cations (step 5). K
+
is then released to the cytosol after ATP binds to the enzyme with ... K
+
ions to flow out of the cytosol. This is
probably the reason for the high toxicity of palytoxin, as the
outflow of K
+
and the resulting collapse of the membrane
potential...
... Hesselbrock V, Meyer RE, Dolin-
sky ZS, Rounsaville B: Types of alcoholics. I: evidence for an
empirically derived typology based on indicators of vulnera-
bility and severity. Arch Gen Psychiatry 1992, ... 1 of 4
(page number not for citation purposes)
Annals of General Psychiatry
Open Access
Review
A short review on the aetiology and pathophysiology of alcoholism
George Moussa...
... VEGF, and bone specific alka-
Editorial
What do biomarkers tell us about the pathogenesis of
ankylosing spondylitis?
Walter P Maksymowych
Department of Medicine, University of Alberta, Edmonton, ... growth
factor (VEGF) but not with serum MMP3 [5,6].
Third, biomarkers may clarify our understanding of the
pathophysiology of disease. Unlike rheumatoid arthritis, there
is still no fo...
... redundancy of
the system, based on in vitro studies. Because one
receptor can usually bind multiple ligands and vice versa,
one may anticipate that blockade of one ligand or receptor
may be compensated ... found in
many inflammatory disorders, including hepatic disease,
multiple sclerosis, transplant rejection and inflammatory
bowel disease [4]. Analysis of synovial tissue, synovial...
... necrosis
factor receptor type II (exon 6) and interleukin-6 (-174) gene
polymorphisms are not associated with family history but
tumor necrosis factor receptor type II is associated with
hypertension ... association between tumour necrosis factor
receptor type 2 gene polymorphism and rheumatoid arthritis
severity: a comparison of the extremes of phenotypes. Rheu-
matology (Oxford) 200...
... capillaries of the synovium and must diffuse
into the synovial fluid and then into the cartilage matrix. Co-
ordinated synthesis and proteolytic breakdown of certain
ECM components by chondrocytes enables ... Elders EM, Gay S, Tomaino MM, et
al.: Clinical trial to assess the safety, feasibility, and efficacy of
transferring a potentially anti-arthritic cytokine gene to human...