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Báo cáo y học: "Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trial" doc

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Báo cáo y học: "Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trial" doc

... care unit.Key messages• Hyperfibrinolysis may play a role in inflammatory response (IR) after cardiopulmonary bypass (CPB).• Inhibition of fibrinolysis with tranexamic acid may attenu-ate ... inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trialJuan J Jimenez1, Jose L Iribarren1, ... was a randomized controlled study and baseline datawere comparable between groups. Additionally, althoughinclusion of patients was prematurely stopped, data analysisdemonstrated that TA attenuates...
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Báo cáo y học: "Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease: a case control study" pdf

... patient at onset of CADsymptoms); and prior coronary artery bypass graft (CABG),myocardial infarction (MI) or percutaneous transluminal coro-nary revascularization (PTCR). Death during the study ... evaluation.Coronary angiogram dataAngiographic data was retrieved from the Mayo Clinic coro-nary care unit database. Mayo Clinic cardiologists who per-formed the study and read each angiogram ... that disease-modifying antirheu-matic drug (DMARD) therapy increases mortality in RA [36].Corticosteroids can cause dyslipidemia, hyperglycemia andhypertension but may also control inflammation...
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Báo cáo y học: "Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB" ppsx

... the myocardial inflammatory process associated toarterial hypertension.This anti -inflammatory effect of captopril has beenpreviously proved in other diseases characterized by anincrease in ... the vascular, renal and cardiac inflammatory processes in different models of arterial hypertension through itsability to activate a variety of inflammation-mediatinggenes. In experimental models ... effect of captopril in arterialhypertension, with a reduction in the circulating pro- inflammatory markers and an increase in those anti- inflammatory cytokines; these effects result in a benefiton...
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Báo cáo y học: "Interleukin-10 gene down-expression in circulating mononuclear cells during infusion of drotrecogin-a activated: a pilot study" pptx

... 1:73-77.5. Joyce DE, Grinnell BW: Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-kappaB. Crit Care Med 2002, ... Critical Care 2010, 14:R163http://ccforum.com/content/14/5/R163Page 5 of 6 of DAA may indicate that a standard dosage of DAAfails to affect outcome.Increased plasma concentration of cytokines ... be a new approach formonitoring the effect of drotrecogin -a (activated) in sepsis.AbbreviationsCMNC: circulating mononuclear cells; DAA: drotrecogin -a activated; EDTA:ethylenediaminetetraacetic...
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Báo cáo y học: "Danaparoid sodium attenuates the increase in inflammatory cytokines and preserves organ function in endotoxemic rats" pot

... inflammation since they have been known to bind and regu-late many inflammatory factors, including inflammatory cytokines, through their HS chains [2-5]. Moreover, recentdata indicate that HS and ... Xa by catalyzing its binding to antithrombin (AT) [1]. Recently, HSand syndecan, a major cell surface HS proteoglycan (HSPG),have attracted much attention as modulators of various types of inflammation ... improvement of coagulation disorder but also theregulation of circulating levels of proinflammatory cytokines mayplay a role in the mechanism.IntroductionDanaparoid sodium (DA) is a low-molecular-weight...
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Báo cáo y học: "Tranexamic acid in cardiac surgery: is there a cause for concern" pps

... withdrawal of aprotinin in certain markets has had two major eff ects.  e fi rst was to cause all of the safety and effi cacy data for aprotinin to be independently examined by regulatory authorities ... epsilon aminocaproic acid and tranexamic acid. Epsilon aminocaproic acid has no approval in Europe or Canada for human adminis-tration, leading to the exclusive use of tranexamic acid in these ... analyses of observational data is published in Critical Care and suggests an increase in mortality, when compared to data from the aprotinin era, in those patients having surgery when a cardiac...
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Báo cáo y học: "Increase of aqueous inflammatory factors in macular edema with branch retinal vein occlusion: a case control study" doc

... this article as: Noma et al .: Increase of aqueous inflammatory factors in macular edema with branch retinal vein occlusion: a case control study. Journal of Inflammation 2010 7:44.Noma et al. ... Itaya M, Sakurai E, Nozaki M, Yamada K, Yamasaki S, Asai K, Ogura Y: Upregulation of VEGF in murine retina via monocyte recruitment afterretinal scatter laser photocoagulation. Invest Ophthalmol ... (intra-assay CV: 5.4%; inter-assay CV: 7.7%).Statistical analysisAll analyses were performed with SAS System 9.1 soft-ware (SAS Institute Inc., Cary, North Carolina, USA).Data are presented as the...
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Báo cáo y học: "CD73 represses pro-inflammatory responses in human endothelial cells" pptx

... puriner-gic receptors [2], although in some cell types purinergicreceptors play a pro -inflammatory role [9]. A 2A and A 2Bpurinergic receptors activate adenylate cyclase, therebyincreasing intracellular ... actomyosin contractilityand strengthening the intercellular junctions [11,12],and A 2B-null mice have increased vascular permeability in response to hypoxia and increased pulmonary leakageafter ... provide ananti -inflammatory signal via adenosine production, lead-ing to increased endothelial barrier function anddecreased leukocyte binding. In addition to increasing endothelial barrier...
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Báo cáo y học: "Mycobacterial immune reconstitution inflammatory syndrome in HIV-1 infection after antiretroviral therapy is associated with deregulated specific T-cell responses: Beneficial effect of IL-2 and GM-CSF immunotherapy" pptx

... the study, carried out pro-liferation assays and bioassays, data analysis and thedesign, coordination, the draft and finalisation of themanuscript. All authors read and approved the finalmanuscript.AcknowledgementsWe ... was included. Control wells for calculation of back-ground activity contained indicator cells only.Phenotypic analysis of lymphocytesPMBC were incubated with a panel of murine anti-humanmAbs ... purposes)Journal of Immune Based Therapies and VaccinesOpen AccessOriginal researchMycobacterial immune reconstitution inflammatory syndrome in HIV-1 infection after antiretroviral therapy is associated...
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Báo cáo y học: "Voluntary activation failure is detectable in some myositis patients with persisting quadriceps femoris weakness: an observational study" ppt

... replacement. Aza, azathioprine; CK, creatinine kinase; CRP, C-reactive protein; CyA, cyclosporin A; DM, dermatomyositis; EMG, electromyography; IIM, idiopathic inflammatory myositis; IU/l, international ... explain. Thus, it is also increasingly rec-ognised in myositis that any correlation between the observedweakness of a muscle and the degree of its inflammatory cellinfiltration at biopsy may ... in which muscle wasting may beradiologically and even clinically obvious, weakness may beexplained by loss of muscle mass which, once established,often appears irreversible. In the early acute...
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