... were
Commentary
Recently published papers: Delivery, volume and outcome – what
is best for our patient?
Lui G Forni
1,2
1
Department of Nephrology & Critical Care, Worthing General Hospital, Lyndhurst ... supporting this approach. This leads on to a
study by Peelen and colleagues published in this journal
examining the influence of volume and ICU organi...
... first few days of the illness,
although they proposed no reason for the observed increase
in mortality in the group treated for fewer than 3 days [5].
What is clear is that hypoglycaemia was ... insulin therapy may not, as suggested
previously, be universally applicable and is not without risk.
This latter point was addressed by Vriesendorp and co-
workers [7]. Since employing...
... VAP has previously been shown to significantly increase
both morbidity and mortality.
Two recent trials [7,8] have shown a reduction in VAP rates
by using antiseptics for oropharyngeal decontamination ... methicillin-resistant Staphylococcus aureus (MRSA).
Colistin has both Gram-positive and negative cover, but is
generally reserved for treatment of multiresistant Gram-
negatives. C...
... reactivity is attenuated by NADR but increased with
AVP and to an even greater extent with F-180. The
implication is that the desired pressor response may be
specifically V1 mediated and therefore this ... by the administration of AVP or TP and
systemic haemodynamic parameters recovered better in the
AVP and TP groups. It is therefore reassuring that mesenteric
ischaemia was not...
... impact
Commentary
Recently published papers:
Pseudomonas
, brain and bowel
injury and novel cardiac therapies
Uma M Bandarupalli and Gareth Williams
University Hospitals of Leicester NHS Trust, Infirmary ... endotracheal tube may reduce this burden. Does
activated protein C improve outcome from acute lung injury and
what is the role played by hyperventilation therapy in t...
... effects of methylprednisolone in
unresolving acute respiratory distress syndrome [10], and
may account for a therapeutic modality by which high-dose
steroid therapy works. It is difficult to ... Although such
reports are somewhat anecdotal, the results are promising for
a condition that is known to carry a high mortality rate, and it
may be that the time for a larger outcome t...
... water
balance. In a study by Lobo and colleagues [4], prompted by
Commentary
Recently published papers: We are what we eat?
LG Forni
Consultant, Worthing General Hospital, Lyndhurst Road, Worthing, ... brine! For those interested, a
balanced view to this work is provided by Heyland and
Paterson [5].
An interesting alternative with respect to volume resuscitation
was recentl...
... Cook and colleagues have
published a timely survey on this issue [16]. They conclude
that a classic case of system failure exists with regard to
patient positioning, and they suggest a number of ... negative
study has been published [18]. The authors randomised a
heterogeneous group of patients who developed respiratory
distress within 48 hours of extubation to receive standard
therap...
... Ventilation
with lower tidal volumes as compared with traditional tidal
volumes for acute lung injury and the acute respiratory dis-
tress syndrome. The Acute Respiratory Distress Syndrome
Network. N Engl ... interventional study so that we can really be
sure that transfusion is as beneficial as we would hope.
Finally, and perhaps fittingly so, what should intensivists do
when, desp...
... review is the lack of consensus on which, if any, agent is
best and the wide variability on what is considered to be a
good measure of best sedation. It is probably a case of not
what you use ... to be considered. It is now widely accepted that
unbridled sedation, given with best of intentions, is harmful in
terms of ventilator and ICU days and consequently outcom...