Báo cáo y học: "Short reflex expirations (expiration reflexes) induced by mechanical stimulation of the trachea in anesthetized cats" ppt

... AbstractFifty spontaneously breathing pentobarbital -anesthetized cats were used to determine the incidence rate and parameters of short reflex expirations induced by mechanical stimulation of the tracheal ... induced by mechanical stimulation of the trachea was similar to the ERg from the glottis. These two reflex responses differ substantially only in the frequency of occurrence in response to mechanical ... thosefound in ERg [4,5,17].Motor pattern of short reflex expiration (ERt) induced by mechanical stimulation of the trachea (stim)Figure 3Motor pattern of short reflex expiration (ERt) induced by mechanical...

Báo cáo y học: "Cough reflex and oral chemesthesis induced by capsaicin and capsiate in healthy never-smokers" ppt

... capsi-noids since cough reflex sensitivity to capsaicin showsprominent gender differences [8,9].Capsaicin acts mainly on the afferent neurons of the non-myelinated C-fibers by the opening of a non-selective ... by capsaicin is called chemesthesis, a sensation of irritation produced by chemical stimulation and medi-ated by the trigeminal nerve [2]. The physiological effects of capsaicin on cough may ... mediators, and by airway and lung pathological changes [34]. Presumably,capsaicin activates PAR indirectly by contraction of airwaysmooth muscle or by an increase in extracellular liquid, or by both...

Báo cáo y học: "Wound healing and inflammation genes revealed by array analysis of ''''macrophageless'''' PU.1 null mice" ppt

... expression, either directly by expressingMcp5 themselves, or indirectly by triggering expression in another cell type, possibly supplying cues that reinforceexpression by mast cells or prevent their ... levels of expression of K6 by the front 10-12rows of wound-edge keratinocytes were confirmed by in situhybridization (Figure 4n).Interestingly, another member of the late effector cluster, the intracellular ... as to the migratory machinery of leukocytes in vivo,informing us, for example, which chemokines might be keyattractive cues by revealing which of the chemokine receptorsare expressed by these...

Báo cáo y học: "Growth-rate regulated genes have profound impact on interpretation of transcriptome profiling in Saccharomyces cerevisiae" pptx

... RAP1.Here, X is the number of transcripts in each phase of the cellcycle found by the cluster analysis and K is the total number of analyzed ORFs in each phase of the cell cycle. N and Z aredefined as ... probability P = Z/N. Here, Z is the number of transcripts in the analyzed cluster, and N denotes the totalnumber of transcripts in the DNA microarray analysis found in the systematic sequence of S288C ... opening of the chromatin gives the transcriptionalmachinery increased access to several neighboring promot-ers) [29,30]. Opening of the chromatin occurs when the nucleosomes are remodeled by...

Báo cáo y học: "Cough reflex sensitivity improves with speech language pathology management of refractory chronic cough" pdf

... determined by their response to the therapy; specifically this included the effectiveness of the technique, the participant’s ability to perform and imple-ment the technique appropriately, their ... was used to complement the cough reflex sensitivity test by measuring any change in the patient’s frequency of coughing after speech pathol-ogy intervention. Data stored on the recorder wasdownloaded ... Voluntary suppression of cough induced by inhalation of capsaicin in healthy volunteers. RespirMed 1993, 87:379-382.34. Davenport PW, Sapienza CM, Bolser DC: Psychophysical assessment of the urge-to-cough....

Báo cáo Y học: Brassica napus soluble epoxide hydrolase (BNSEH1) Cloning and characterization of the recombinant enzyme expressed in Pichia pastoris docx

... hydrolase genes inferred by data mining of the genome sequence [22] are intrinsically divergentFig. 5. Eﬀects of inhibitors on recombinant BNSEH1 enzyme activity.Enzyme activity was determined ... protein of 318 amino acid residues. The recombinant enzyme wasfunctional and readily detected by assay of TSO hydrolysis in yeast extracts upon over-expression in P. pastoris using amethanol inducible ... inhibitoryeffects on the hydrolysis of TSO by the recombinant enzyme(Fig. 5). N,N¢-dicyclohexylcarbodiimide was found to be apotent inhibitor and 10 lM of this compound abolishedenzyme activity. The corresponding...

Báo cáo y học: "Platelet-Activating Factor Antagonists Decrease Follicular Dendritic-Cell Stimulation of Human B Lymphocytes" pptx

... to B lymphocytes, FDCs, or the combination of B lymphocytes and FDCs at the initiation of cul-ture, and supernatants were harvested after 7 days of incubation. In keeping with the purity of ourFDCs, ... effect,decreasing cell proliferation (as measured by [3H]-thymidine incorporation) by 35% and the produc-tion of IgM and IgG by the isolated tonsillar cells by 45 to 75%. This was seen over doses rangingfrom ... forprostaglandins in their function.12 In these pre-liminary studies, we tested whether the PAF antag-onist WEB 2170 could inhibit FDC-mediated stimulation of B lymphocytes.FDCs support B-lymphocyte...

Báo cáo y học: "Do synovial biopsies help to support evidence for involvement of innate immunity in the immunopathology of Behçet’s disease" pot

... that innate immunity is also involved in early BDand interacts with adaptive immunity, as reflected by the presence of perforin, presumably secreted by CD3+T cells. Itmight therefore be of interest ... to obtain samples; it is only evaluated in intensivelyand chronically treated BD patients. In contrast to most of the inflamed organs in BD, the joint issterile and frequently involved in BD. ... readily influenceobservations in inflammatory cells. On the other hand, thosemicro-organisms are also capable of stimulating an immuneresponse in BD. Most tissue studies of the pathophysiologyof...

Báo cáo y học: "Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide" pot

... arthritis.Understanding the inhibitory mechanisms of APLs may pave the way for the development of novel therapies for arthritis induced by autoimmune responses to ubiquitous antigens.IntroductionRheumatoid ... examina-tions show that most of the lymphocytes infiltrating the syn-ovium in RA are CD4+ T cells, which can recognize someantigens and expand oligoclonally intraarticularly [1]. Thesefindings ... experiments. YY,AI, YK, KY YT, and RM assisted in the completion of the exper-iments. TS designed and coordinated the study. IM coordi-nated and directed the study. YN designed the APLs andprovided...

Báo cáo y học: " Stress response regulators identified through genome-wide transcriptome analysis of the (p) ppGpp-dependent response in Rhizobium " docx

... (p)ppGpp-deficient.However,duetothesensitivityoftheassay,thepre-sence of trace amounts of (p)ppGpp in the rsh mutant,possibly resulting from the presence of an as yet uniden-tified synthetase gene, cannot ... carbohydratemetabolism were induced by (p)ppGpp, including the transaldolase tal of the pentose pathway, glgC involved in starch and sucr ose metabolism, the glycolytic genefbaB and the gene encoding trehalose-6-phophatase,otsB. ... the classical model in E. coli.Other genes encoding parts of the translationalmachinery that were positively regulated by (p)ppGpp in R. etli include the homolog of E. coli yhbH (CH00406)and...

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