... Germany.2Interdisciplinary Centre for Clinical Trials (IZKS), UniversityMedical Centre, Mainz, Germany.3Clinic for Psychiatry and Psychotherapy,Katzenelnbogen, Germany.4Clinic for Psychiatry ... the dysreg ulation of the immuno-inflammatory system with the aetiology and the pathophysiology of MDD.Recently, a larger panel of pro- a nd anti-inflammatorycytokines was measured in a case/control ... biomark ers for the finally achieved changes of these markers and, even more important, depressionseverity. For the investigation of the predictive value of early chang es of biomarkers for final treatment...