... overdu-plication. Embo J 2000, 19:2069-2081.43. Nakayama K, Nagahama H, Minamishima YA, Miyake S, Ishida N,Hatakeyama S, Kitagawa M, Iemura S, Natsume T, Nakayama KI:Skp2-mediated degradation of p27 ... (WT-Tax) or its equivalent carrying each of five mutant tax alleles and plated on agar plates containing 2% raffinose or 2% raffinose plus 2% galactose. The amino acid alterations in tax mutants ... with the senescence-like arrest may facilitate virus assembly and/ or transmis-sion. Many of the tax mutants characterized here thatremain functional in transactivating viral LTR and NF-κBcan...