Báo cáo y học: "Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication" doc
Báo cáo y học: "Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication" doc
... AccessResearchContribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replicationZaikun Xu†1, Yingfeng Zheng†1, ... mutagenicanalyses of the C-terminal region of the catalytic core domain of HIV-1 IN in order to delineate the criticalamino acid(s) and/ or motif(s) required for the induction of the lethal phenotype in the yeast ... determine the importance of the C-terminal region of the catalytic core domain of HIV-1 IN in the viral life cycle,we have generated a series of IN mutations. These mutantsallowed us to delineate the...
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Báo cáo Y học: Contribution of Lys276 to the conformational flexibility of the active site of glutamate decarboxylase from Escherichia coli pptx
... but ultimately tight, binding of PLP to the apoenzyme in vitro and for the fact thatpreparations of the mutant enzymes are always largely asapoenzyme. Similarly, inflexibility of the protein ... Conversely, the less hydrated environ-ment of the high-pH conformation favors the 340 nm-absorbing enolimine tautomer of the wild-type cofactor and the 388 nm-absorbing unhydrated aldehyde of PLP ... wild-type and mutant enzymes is that the pH-dependent conformational change induces an alteration in the polarity of the active site. In this hypothesis, the environment of the cofactor is more hydrated...
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Báo cáo y học: "Contribution for new genetic markers of rheumatoid arthritis activity and severity: sequencing of the tumor necrosis factor-alpha gene promoter" docx
... histologically proved), non-compressive neuropathyconfirmed by electromyography, or the diagnosis of Sjögrensyndrome based on the clinical symptoms of dry eyes and drymouth (confirmed by a ... test and/ or kerato-conjunctivitis sicca with involvement of salivary glands docu-mented by positive lip biopsy and/ or salivary scintigraphy).Simple x-rays of the hands and feet were analyzed ... function of the SvdH score (Figure 2a) showed thatpatients with less than 2 years and those with 2 to 10 years of DD could not be separated into two groups by any SvdHscore cutoff point. The method...
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Báo cáo y học: " Contribution of the C-terminal tri-lysine regions of human immunodeficiency virus type 1 integrase for efficient reverse transcription and viral DNA nuclear import" pps
... of the protein. The position of lysines in two tri-lysine regions and introduced mutations are shown at the bottom of sequence. B) The expression of the wild-type and mutant IN-YFP fusion proteins ... of lysine residues and therefore, we termthem proximal tri-lysine region and distal tri-lysine region, respectively (Fig. 2A). All of these lysine residuesare highly conserved in most HIV-1 ... attempt to analyze the effect of thesemutants during HIV-1 replication, other studies did notreveal the importance of these IN mutants (K186Q and Q214/216L) for viral nuclear import; rather they...
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Báo cáo y học: "Technical Considerations in Decompressive Craniectomy in the Treatment of Traumatic Brain Injury"
... d b y loose closure of the dura and skin layers presum a b l y allows for expansion of the edematous brain into a durotomy “bag” under the loosely closed scalp without restriction by the ... meninges. The method using temporal fascia is similar to the one introduced by Yu et al.32 They separated the temporal deep fascia from the temporal muscle to the zygomatic arch, and then cut the ... pedicle of temporal f as ci a that maintains the blood supply. Brain herniation via the craniectomy defect may lead to compression of vessels and result in ischemic necrosis of the portion of the...
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Báo cáo y học: " Laugh Yourself into a Healthier Person: A Cross Cultural Analysis of the Effects of Varying Levels of Laughter on Health"
... score was thirty-seven. Lifestyle Q1 to Lifestyle Q3 were equally weighted and represented 81% of the total value of the questions, whereas, Lifestyle Q4 and Lifestyle Q5 represented only ... CNS and psychiatric conditions, and then to specify the name of that con-dition. If the participant failed to indicate the name of the condition regardless of a “yes”, the survey was discarded ... at the University of Toronto, being awarded an academic scholarship from the University of Toronto. He was chosen for the Research Opportunity Program, to pursue research in the field of...
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Tài liệu Báo cáo Y học: Soluble silk-like organic matrix in the nacreous layer of the bivalve Pinctada maxima A new insight in the biomineralization field pptx
... composition was very similar to the WSM, and consequently the EDTA-IM. Hydroxyproline, hydroxy-lysine and phosphoserine were not detected in WSM, WIM,EDTA-SM and EDTA-IM. The comparison of the amino ... Proline, hydroxyproline and hydroxylysine were examined at 254 nm by reverse-phaseHPLC of their phenylisothiocarbamate derivatives [26], asreported previously [20]. The serine, threonine and tyrosinecontents ... in the biomineralization process. Someimportant roles were ascribed to them as the control of nucleation, the growth and the inhibition of crystal forma-tion [8,73]. The other compounds of the...
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Tài liệu Báo cáo Y học: BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro Implications in the BIGH3-linked corneal dystrophies pptx
... decades of life and severely impair visualacuity in adulthood. Their therapy is restricted to keratopl-asty and phototherapeutic keratectomy by Excimer laser.Unfortunately, the benefits of these therapies ... that Cys–Cys bondformation does facilitate amyloid precipitation, but is not the only factor responsible for the amyloidogenicity of C110)131 peptide. The participation of other factors inamyloidogenesis, ... propensity of big-h3 110)122 to form amyloid spontaneously as it displayed the highest ThT signal from day 1 to day 15 and had the fastest aggregation kinetics (Fig. 3). The higher amyloi-dogenicity...
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Tài liệu Báo cáo Y học: Interallelic complementation provides genetic evidence for the multimeric organization of the Phycomyces blakesleeanus phytoene dehydrogenase doc
... pathway to b-carot eneproceeds via three enzymatic steps carried out by the enzymes phytoene synthase, phytoene dehydrogenase and lycopene cyclase. The enzyme phytoene dehydrogenase isable to ... bothZygomycetes. In Phycomyces they complement neither the carR nor the carA mutants, and i n Mucor they complementneither the carP nor the carR mutants. They are white, l ackall carotenoids and ... wouldconsist of four copies of the enzyme phytoene dehydro-genase, which act sequentially on a molecule of phytoene,converting it successively in phyto¯uene, f-ca rotene,neurosporene and lycopene, and...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
... confirming the heterozygous sta-tus (M/F) of the sample analysed.Experimental strategy designed to analyse the newas1-Cas variant at the nucleotide level To determine the coding sequence of a ... material to synthesize cDNA. However, as expectedfrom the phen otypic analysis (at the p rotein level), the f ewanimals yielding in their milk the as1-CasM variant wereexclusively heterozygous ... the course of the processing of the primary transcripts [9]. At the peptidelevel, the CfiT transition, which leads to a Ser66 fi Leu66substitution, gives rise to the loss of two of the fivephosphate...
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